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Volume 5, Issue 1
  • ISSN: 2665-9786
  • E-ISSN: 2665-9794

Abstract

Background

D. Don is a Chinese herb, that belongs to the family Lamiaceae. It has established traditional use in ethnomedicine for treating various ailments, including mood disorders and sleep disorders, which led to growing interest in exploring its neurological potential, particularly as a potential anti-depressant agent.

Aims

This study explores the anti-depressant potential of the HSBE utilizing a Chronic Unpredictable Mild Stress-induced depression model in mice. Additionally, the research aims to elucidate the underlying mechanisms of action.

Methods

Swiss albino mice were subjected to a 3-week CUMS paradigm and subsequently administered HSBE at doses of 200 and 400 mg/kg oral administration. The behavioral alterations were evaluated using the FST, TST, OFT, and SPT. Brain levels of serotonin, dopamine, and nor-epinephrine were estimated in different brain regions (cortex, hippocampus, and hypothalamus) to uncover the molecular mechanism. Additionally, assays for monoamine oxidase-A, monoamine oxidase-B, and antioxidant enzyme activities were conducted. Plasma nitrite and corticosterone levels were also measured to get further insight into potential mechanisms underlying the anti-depressant effects of HSBE.

Results

HSBE significantly ameliorated depressive-like behavior induced by CUMS paradigm, as evidenced by reduced immobility in FST and TST, increased locomotor activity in OFT, and improved sucrose preference in SPT. Neurochemical analysis revealed a significant increase in serotonin, dopamine, and norepinephrine levels in the cortex, hippocampus, and hypothalamus of HSBE-treated mice, implying a potential regulation of monoaminergic neurotransmitter levels. Moreover, biochemical analyses demonstrated a significant inhibition of both MAO-A and MAO-B activity, contributing to the increase of the brain levels of neurotransmitters. The administration of HSBE also led to a significant enhancement of antioxidant enzyme activities and reduced brain lipid peroxidation, indicating a pronounced antioxidant effect of HSBE. Furthermore, decreased plasma nitrite and corticosterone levels provided additional insights into HSBE's potential multi-targeted anti-depressant mechanism.

Conclusion

This study indicates that HSBE exhibits robust anti-depressant properties, supported by behavioral, neurochemical, and biochemical alterations. These findings underscore the therapeutic promise of HSBE as a natural intervention for depressive disorders, warranting further clinical exploration.

© 2024 Bentham Science Publishers
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2024-08-06
2024-12-25

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/content/journals/cnt/10.2174/0126659786304405240709114804
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Evaluation of Anti-Depressant Potential of Standardized Hydroethanolic Extract of S. barbata D. Don Using Chronic Unpredictable Mild Stress Model
Current Nutraceuticals 5, E26659786304405 (2024); https://doi.org/10.2174/0126659786304405240709114804
/content/journals/cnt/10.2174/0126659786304405240709114804
/content/journals/cnt/10.2174/0126659786304405240709114804
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  • Article Type:     Research Article
Keyword(s): anti-depressant; anti-oxidant; Depression; flavonoids; Scutellaria barbata d. don; traditional chinese medicine

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