Central Nervous System Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Central Nervous System Agents) - Volume 25, Issue 1, 2025

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder affecting elderly individuals, characterized by progressive cognitive decline leading to dementia. This review examines the challenges posed by anatomical and biochemical barriers such as the blood-brain barrier (BBB), blood-cerebrospinal fluid barrier (BCSFB), and p-glycoproteins in delivering effective therapeutic agents to the central nervous system (C Read More

Recently, traumatic brain injury (TBI) has been a growing disorder due to frequent brain dysfunction. The Glasgow Coma Scale expresses TBI as classified as having mild, moderate, or severe brain effects, according to the effects on the brain. Brain receptors undergo various modifications in their pathology through chemical synaptic pathways, leading to depression, Alzheimer's, and Parkinson's disease. These brain disorders Read More

Alzheimer's Disease (AD) is a devastating neurological condition characterized by a progressive decline in cognitive function, including memory loss, reasoning difficulties, and disorientation. Its hallmark features include the formation of neurofibrillary tangles and neuritic plaques in the brain, disrupting normal neuronal function. Neurofibrillary tangles, composed of phosphorylated tau protein and neuritic plaques, containing a Read More

BackgroundSeizures are a common presenting symptom of the central nervous system (CNS) and could occur from infections (such as toxins) or drugs.ObjectiveThe aim of this study was to present a systematic review of the association between infections, seizures, and drugs.MethodsFrom their inception to 18 February 2024 relevant in-depth consequent guide approach and the evidence-based choice were selected associat Read More

AimThe purpose of the current study was to explore the virtual library for the screening against Monoamine oxidase (MAO) isoforms. An in-house library of natural based ligands was docked within the active sites of MAO isoforms and their in vitro study was also conducted.ObjectiveThe prime objective of the current study was to screen and validate the natural-based derivatives for MAO inhibitory action with the least adverse Read More

BackgroundAlzheimer’s disease is a neurodegenerative disorder that affects learning, memory and behavioral turbulence in elderly patients. Acetylcholinesterase (AChE) inhibitors act as anti-Alzheimer’s agents. Phenothiazine derivatives are considered momentous anti-Alzheimer’s agents because of their AChE inhibitory activity. The elevated levels and increased expression of this protein have been associated with Alzheim Read More