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Abstract

The greatest and most noticeable organ in the body is the skin. The stratum corneum, or top layer of skin, acts as a vital barrier to prevent skin penetration for many drugs. To overcome this barrier, numerous nanocarrier frameworks have been developed, which are important for the functioning of active agents. Vascular systems known as invasomes contain low levels of ethanol as well as terpenes or terpene combinations, which have a higher skin penetration rate and function as potential carriers. Improved drug delivery the skin using a carrier that can penetrate these barriers presents a wide range of difficulties and possibilities for further study and the creation of new and better treatment options. The main objective of an invasome-based delivery system is to significantly improve patient compliance and therapeutic value, in addition to bolstering the safety and efficacy of the drug. This article gives a summary of the synthesis process, invasome characterizations, penetration mechanisms, and applications. This review paper also includes phospholipids and their classification. Phospholipids are present in the cell membrane and provide ceramide, a bioactive molecule that moisturizes skin and protects against environmental damage in transdermal drug delivery systems. Pharmaceutical studies demonstrate that many drug molecules have less solubility, stability, bioavailability, and penetrating power. Invasomes represent a novel dosage form with promising properties for enhancing transdermal drug delivery.

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2024-11-23

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/content/journals/cnanom/10.2174/0124681873327435241004053618
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Invasomes: An Artificial Vesicle Nanocarrier to Enhance Transdermal Drug Delivery
Bentham Science Publishers ; https://doi.org/10.2174/0124681873327435241004053618
/content/journals/cnanom/10.2174/0124681873327435241004053618
/content/journals/cnanom/10.2174/0124681873327435241004053618
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  • Article Type:     Review Article
Keywords: Terpenes ; Stratum corneum ; invasomes ; Patient compliance ; Therapeutic value ; nanocarrier

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