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Volume 18, Issue 3
  • ISSN: 2666-1454
  • E-ISSN: 2666-1462

Abstract

One of the most promising novel drug delivery systems is an gel, which uses a unique 'Sol to Gel' conversion to help with the slow and steady release of pharmaceuticals. An gel system enters the body as a solution but transforms into a gel once it encounters the body's internal environment. Traditional methods of ocular drug delivery, such as suspensions, eye drops, and ointments, have a number of drawbacks. These include lacrimation, obscured vision, and, most importantly, rapid precorneal clearance. As a result, many innovative methods have been created in order to address these shortcomings. gel, minidisc, ocusert, nanosuspension, collagen shield, nanoparticulate, system, niosomes, ocular iontophoresis, liposome, ocular film, dendrimers, and other methods are among them. Ocular medication delivery systems have come a long way recently, and one of the most recent innovations is ocular gel. The polymers (natural, semisynthetic, or synthetic) that make up the ocular gel system's delivery vehicle have the unique feature of a sol-gel transition when subjected to the effect of a biological stimulus, such as a change in temperature, pH, or ions. Physical appearance, clarity, pH, gelling ability, isotonicity evaluation, sterility, viscosity, drug release, and irritancy tests are all investigated in ocular gels.

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2025-04-23

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In-situ Gelling Platform for Ocular Drug Delivery System: A New Paradigm
Current Materials Science 18, 339 (2025); https://doi.org/10.2174/2666145417666230821151753
/content/journals/cms/10.2174/2666145417666230821151753
/content/journals/cms/10.2174/2666145417666230821151753
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  • Article Type:     Review Article
Keyword(s): drug delivery system; In-situ ocular gel; ion-activated systems; nanoparticles; pH-induced in-situ gel system; temperature-induced in-situ gel system

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