Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Indian Science
  4. Volume 1, Issue 1
  5. Article
Volume 1, Issue 1
  • ISSN: 2210-299X
  • E-ISSN: 2210-3007
file format pdf download PDF
side by side viewer icon HTML

Abstract

Rosacea, a prevalent dermatological condition, is characterized by the clinical manifestations of erythema, papules, and pustules. This paper delves into the emerging role of the gut-skin axis in Rosacea's pathophysiology. Convincing evidence supports the involvement of gut microbiota in orchestrating the inflammatory cutaneous response. Its multifaceted etiology is thought to be influenced by genetic susceptibility, alterations in the neurovascular and immune systems, and altered interactions with the microbiota. Strong connections broaden our understanding of Rosacea, linking it to neurological conditions like Parkinson's disease and gastrointestinal issues such as Helicobacter pylori infection and small intestinal bacterial overgrowth (SIBO), supporting the existence of an intricate brain-gut-skin connection. The interplay between these organs' homeostatic and regulatory systems is increasingly evident. While we have not fully grasped the details of immunological, neuroendocrine, and metabolic pathways, it is clear they play a part in chronic inflammatory skin conditions like Rosacea. Delving into these intricate pathways promises a nuanced comprehension of the disease's etiopathogenesis. An in-depth investigation into the roles of dysbiotic microbiota and dysregulated innate immune responses is imperative to comprehensively fathom Rosacea's pathophysiological landscape. A refined grasp of this condition and the gut-skin axis holds the potential for optimizing therapeutic trajectories. The purpose of this review is to explore potential bacterial indicators of the disease and to assess whether the gut microbiome makeup of individuals with inflammatory Rosacea differs from that of healthy controls. Furthermore, it critically assesses and consolidates previously documented alterations in peripheral blood, skin, and gastrointestinal tract microbiomes within rosacea patients. This review illuminates the intricate dance of microbiota in the context of Rosacea, forging a bridge between cutting-edge insights and its implications. By synthesizing current knowledge, this review advances our understanding of microbiota-driven mechanisms in inflammatory Rosacea, paving the way for innovative therapeutic strategies.

© 2023 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Loading

Article metrics loading...

/content/journals/cis/10.2174/012210299X253718231006043520
2023-10-23
2025-05-23

  • From This Site

    /content/journals/cis/10.2174/012210299X253718231006043520
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
The full text of this item is not currently available.

References

  1. CrawfordG.H. PelleM.T. JamesW.D. Rosacea: I. Etiology, pathogenesis, and subtype classification.J. Am. Acad. Dermatol.200451332734110.1016/j.jaad.2004.03.03015337973
     [Google Scholar]
  2. JarmudaS. O’ReillyN. ŻabaR. JakubowiczO. SzkaradkiewiczA. KavanaghK. Potential role of Demodex mites and bacteria in the induction of rosacea.J. Med. Microbiol.201261111504151010.1099/jmm.0.048090‑022933353
     [Google Scholar]
  3. QinJ. LiR. RaesJ. ArumugamM. BurgdorfK.S. ManichanhC. NielsenT. PonsN. LevenezF. YamadaT. MendeD.R. LiJ. XuJ. LiS. LiD. CaoJ. WangB. LiangH. ZhengH. XieY. TapJ. LepageP. BertalanM. BattoJ.M. HansenT. Le PaslierD. LinnebergA. NielsenH.B. PelletierE. RenaultP. Sicheritz-PontenT. TurnerK. ZhuH. YuC. LiS. JianM. ZhouY. LiY. ZhangX. LiS. QinN. YangH. WangJ. BrunakS. DoréJ. GuarnerF. KristiansenK. PedersenO. ParkhillJ. WeissenbachJ. BorkP. EhrlichS.D. WangJ. A human gut microbial gene catalogue established by metagenomic sequencing.Nature20104647285596510.1038/nature0882120203603
     [Google Scholar]
  4. Fitz-GibbonS. TomidaS. ChiuB.H. NguyenL. DuC. LiuM. ElashoffD. ErfeM.C. LoncaricA. KimJ. ModlinR.L. MillerJ.F. SodergrenE. CraftN. WeinstockG.M. LiH. Propionibacterium acnes strain populations in the human skin microbiome associated with acne.J. Invest. Dermatol.201313392152216010.1038/jid.2013.2123337890
     [Google Scholar]
  5. AleksandrowiczK. KiedrowskiM. WalenckaE. A study of the skin microbiome in psoriasis: What we know and what we do not know.Dermatology2019235645546010.1159/000502309
     [Google Scholar]
  6. DinleyiciE.C. ErenM. OzenM. YargicZ.A. The effect of chronic Helicobacter pylori infection on gut-brain axis.FEMS Immunol. Med. Microbiol.2012631939810.1111/j.1574‑695X.2011.00918.x
     [Google Scholar]
  7. ByrdA.L. BelkaidY. SegreJ.A. The human skin microbiome.Nat. Rev. Microbiol.201816314315510.1038/nrmicro.2017.15729332945
     [Google Scholar]
  8. FosterJ.A. RinamanL. CryanJ.F. Stress & the gut-brain axis: Regulation by the microbiome.Neurobiol. Stress2017712413610.1016/j.ynstr.2017.03.00129276734
     [Google Scholar]
  9. FrançaK. Topical probiotics in dermatological therapy and skincare: A concise Review.Dermatol. Ther.2021111717710.1007/s13555‑020‑00476‑733340341
     [Google Scholar]
  10. EgebergA. WeinstockL.B. ThyssenE.P. GislasonG.H. ThyssenJ.P. Rosacea and gastrointestinal disorders: A population‐based cohort study.Br. J. Dermatol.2017176110010610.1111/bjd.1493027501017
     [Google Scholar]
  11. WangF.Y. ChiC.C. Rosacea, germs, and bowels: A review on gastrointestinal comorbidities and gut–skin axis of rosacea.Adv. Ther.20213831415142410.1007/s12325‑021‑01624‑x33507499
     [Google Scholar]
  12. ThompsonK.G. RainerB.M. KangS. ChienA.L. The skin microbiota as a link between rosacea and its systemic comorbidities.Int. J. Dermatol.202059451351410.1111/ijd.1480232043275
     [Google Scholar]
  13. LeeY.B. ByunE.J. KimH.S. Potential role of the microbiome in acne: A comprehensive review.J. Clin. Med.20198798710.3390/jcm807098731284694
     [Google Scholar]
  14. HasanN. YangH. Factors affecting the composition of the gut microbiota, and its modulation.Peer J.20197e750210.7717/peerj.750231440436
     [Google Scholar]
  15. BoweW.P. LoganA.C. Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future?Gut Pathog.201131110.1186/1757‑4749‑3‑121281494
     [Google Scholar]
  16. GriceE.A. KongH.H. ConlanS. DemingC.B. DavisJ. YoungA.C. BouffardG.G. BlakesleyR.W. MurrayP.R. GreenE.D. TurnerM.L. SegreJ.A. Topographical and temporal diversity of the human skin microbiome.Science200932459311190119210.1126/science.117170019478181
     [Google Scholar]
  17. TwoA.M. WuW. GalloR.L. HataT.R. Rosacea: part I. Introduction, categorization, histology, pathogenesis, and risk factors.J. Am. Acad. Dermatol.201572574975810.1016/j.jaad.2014.08.02825890455
     [Google Scholar]
  18. ManzhaliiE. HornussD. StremmelW. Intestinal-borne dermatoses significantly improved by oral application of Escherichia coli Nissle 1917.World J. Gastroenterol.201622235415542110.3748/wjg.v22.i23.541527340358
     [Google Scholar]
  19. FortunaM.C. GarelliV. PrantedaG. RomanielloF. CardoneM. CarlesimoM. RossiA. A case of scalp rosacea treated with low dose doxycycline and probiotic therapy and literature review on therapeutic options.Dermatol. Ther.201629424925110.1111/dth.1235527087407
     [Google Scholar]
  20. SteinhoffM.B.J. Chapter 79: Rosacea.Fitzpatrick’s Dermatology. KangSAM. BrucknerAL. McMichaelAJ. 9th ed.Mc Graw Hill Education2019
     [Google Scholar]
  21. ArckP. HandjiskiB. HagenE. PincusM. BruenahlC. BienenstockJ. PausR. Is there a ‘gut-brain-skin axis’?Exp. Dermatol.201019540140510.1111/j.1600‑0625.2009.01060.x20113345
     [Google Scholar]
  22. NamJ.H. YunY. KimH.S. KimH.N. JungH.J. ChangY. RyuS. ShinH. KimH.L. KimW.S. Rosacea and its association with enteral microbiota in Korean females.Exp. Dermatol.2018271374210.1111/exd.1339828636759
     [Google Scholar]
  23. ChenYJ LeeWH HoHJ TsengCH WuCY An altered fecal microbial profiling in rosacea patients compared to matched controls.J. Formosan Med. Assoc.20211201 Pt 125626410.1016/j.jfma.2020.04.034
     [Google Scholar]
  24. SalemI. RamserA. IshamN. GhannoumM.A. The gut microbiome as a major regulator of the gut-skin axis.Front. Microbiol.20189145910.3389/fmicb.2018.0145930042740
     [Google Scholar]
  25. SamuelsonD.R. WelshD.A. ShellitoJ.E. Regulation of lung immunity and host defense by the intestinal microbiota.Front. Microbiol.20156108510.3389/fmicb.2015.0108526500629
     [Google Scholar]
  26. RiordanS.M. McIverC.J. ThomasD.H. DuncombeV.M. BolinT.D. ThomasM.C. Luminal bacteria and small-intestinal permeability.Scand. J. Gastroenterol.199732655656310.3109/003655297090250999200287
     [Google Scholar]
  27. O’NeillC.A. MonteleoneG. McLaughlinJ.T. PausR. The gut-skin axis in health and disease: A paradigm with therapeutic implications.BioEssays201638111167117610.1002/bies.20160000827554239
     [Google Scholar]
  28. YangX. Relationship between helicobacter pylori and rosacea: Review and discussion.BMC Infect. Dis.201818131810.1186/s12879‑018‑3232‑429996790
     [Google Scholar]
  29. SzlachcicA. The link between helicobacter pylori infection and rosacea.J. Eur. Acad. Dermatol. Venereol.200216432833310.1046/j.1468‑3083.2002.00497.x12224687
     [Google Scholar]
  30. SharmaV.K. LynnA. KaminskiM. VasudevaR. HowdenC.W. A study of the prevalence of helicobacter pylori infection and other markers of upper gastrointestinal tract disease in patients with rosacea.Am. J. Gastroenterol.199893222022210.1111/j.1572‑0241.1998.00220.x9468246
     [Google Scholar]
  31. SpoendlinJ. KaratasG. FurlanoR.I. JickS.S. MeierC.R. Rosacea in patients with ulcerative colitis and crohn’s disease: A population-based case-control study.Inflamm. Bowel Dis.201622368068710.1097/MIB.000000000000064426717319
     [Google Scholar]
  32. TóthováI. TóthováI. BaumgartnerJ. FiloV. Eradication of Helicobacter pylori as the only successful treatment in rosacea.Arch. Dermatol.199613211139310.1001/archderm.1996.038903501370328915328
     [Google Scholar]
  33. KagnoffM.F. Celiac disease: Pathogenesis of a model immunogenetic disease.J. Clin. Invest.20071171414910.1172/JCI3025317200705
     [Google Scholar]
  34. AbenavoliL. DastoliS. BennardoL. BoccutoL. PassanteM. SilvestriM. ProiettiI. PotenzaC. LuzzaF. NisticòS.P. The skin in celiac disease patients: The other side of the coin.Medicina201955957810.3390/medicina5509057831505858
     [Google Scholar]
  35. LiS. ChoE. DruckerA.M. QureshiA.A. LiW.Q. Alcohol intake and risk of rosacea in US women.J. Am. Acad. Dermatol.201776610611067.e210.1016/j.jaad.2017.02.04028434611
     [Google Scholar]
  36. HolmesA.D. SpoendlinJ. ChienA.L. BaldwinH. ChangA.L.S. Evidence-based update on rosacea comorbidities and their common physiologic pathways.J. Am. Acad. Dermatol.201878115616610.1016/j.jaad.2017.07.05529089181
     [Google Scholar]
  37. LiebregtsT. AdamB. BredackC. RöthA. HeinzelS. LesterS. Downie-DoyleS. SmithE. DrewP. TalleyN.J. HoltmannG. Immune activation in patients with irritable bowel syndrome.Gastroenterology2007132391392010.1053/j.gastro.2007.01.04617383420
     [Google Scholar]
  38. JahnsAC LundskogB DahlbergI TamayoNC McDowellA PatrickS AlexeyevOA No link between rosacea and Propionibacterium acnes.APMIS20121201192292510.1111/j.1600‑0463.2012.02920.x
     [Google Scholar]
  39. LiChunxiao Gut microbiota differs between parkinson's disease patients and healthy controls in northeast China.Front. Mol. Neurosci.20191217110.3389/fnmol.2019.00171
     [Google Scholar]
  40. KowalchukG.A. SpeksnijderA.G.C.L. ZhangK. GoodmanR.M. van VeenJ.A. Finding the needles in the metagenome haystack.Microb. Ecol.200753347548510.1007/s00248‑006‑9201‑217345132
     [Google Scholar]
  41. RainerB.M. FischerA.H. Luz Felipe da SilvaD. KangS. ChienA.L. Rosacea is associated with chronic systemic diseases in a skin severity–dependent manner: Results of a case-control study.J. Am. Acad. Dermatol.201573460460810.1016/j.jaad.2015.07.00926256428
     [Google Scholar]
  42. DaouH. ParadisoM. HennessyK. Seminario-VidalL. Rosacea and the microbiome: A systematic review.Dermatol. Ther.202111111210.1007/s13555‑020‑00460‑133170492
     [Google Scholar]
  43. Moreno-ArronesO.M. Ortega-QuijanoD. Perez-BrocalV. Fernandez-NietoD. JimenezN. las HerasE. MoyaA. Perez-GarciaB. Dysbiotic gut microbiota in patients with inflammatory rosacea: Another clue towards the existence of a brain-gut-skin axis.Br. J. Dermatol.2021185365565710.1111/bjd.2041133913159
     [Google Scholar]
/content/journals/cis/10.2174/012210299X253718231006043520
Loading
Gut–Skin Axis: Gut Microbiota as a Link Between Rosacea and Gastrointestinal Comorbidities
Curr. Indian Sci. 1, E2210299X253718 (2023); https://doi.org/10.2174/012210299X253718231006043520
/content/journals/cis/10.2174/012210299X253718231006043520
/content/journals/cis/10.2174/012210299X253718231006043520
Loading

Data & Media loading...


  • Article Type:     Review Article
Keyword(s): Dysbiosis; Gastrointestinal tract; Gut microbiota; Rosacea; SIBO; Skin-gut axis

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test