Current Drug Therapy - Volume 17, Issue 2, 2022

Backgrounds: Plant and derived herbal drugs have been used in the traditional medicine system to treat various human health complications from a very early age. Commercial products prepared from natural herbs have always been valuable for society in the form of health supplements to medicament. In ancient times, herbal products were mainly prepared from plants and derived phytochemicals. Plants contain a rich sou Read More

Human skin has been explored for decades as a potential route for the delivery of various substances. It has shown considerable promise for the delivery of medications into the systemic circulation. It is also beneficial to treat local skin symptoms through the skin itself. However, the rigid stratum corneum layer has served as the biggest barrier to transdermal drug delivery. Various methods have been designed to overcom Read More

Rheumatoid arthritis (RA) is the most common musculoskeletal disease in the world. The clinical prospects have increased tremendously since the advent of biological agents as therapy options. NSAIDs such as indomethacin, celecoxib, and etoricoxib are used often in the treatment of RA but off-target effects decrease their use. DMARDs such as methotrexate and etanercept were also effective in the treatment of RA, but toler Read More

Tyrosine Kinase (TK) is considered one of the important family members of the kinase family due to its important role in various cellular processes like cell growth, cell differentiation, apoptosis, etc. Mutation, overexpression, and dysfunction of tyrosine kinase receptors lead to the development of malignancy; thus, they are considered one of the important targets for the development of anti-cancer molecules. The tyrosine kinas Read More

Background: Coronary Heart Disease (CHD) patients are at risk of suffering from drug interactions, leading to a higher risk of mortality and morbidity among these patients. This study aims to identify the potential drug-drug interactions (PDDIs) and CHD patients' related factors. Methods: A cross-sectional study was performed among the CHD patients to identify the PDDIs from 2014 to 2017 at a Secondary Hospital. The P Read More

Background: The evolving need and facilitation of topical formulations have risen in the present era. Topical industries are continually striving to satisfy patients with newer and innovative products. However, dry skin is the critical factor contributing to drug penetration into the skin. Objectives: The current research aims to develop cost-effective and commercially feasible industrial scale microemulsion of wheat germ oil to enric Read More

Background: Pro-inflammatory mediators such as tumor necrosis factor-alpha (TNF-α), interleukin (IL), and oxidative stress are crucial players in the pathophysiology of inflammatory bowel disease (IBD) that contribute to perpetuating intestinal inflammation. Targeting them presents a novel approach to disease management. In the present study, the potential of an antiosteoarthritic ILinhibitor drug, diacerein (DIA), was invest Read More