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- Volume 17, Issue 4, 2022
Current Drug Therapy - Volume 17, Issue 4, 2022
Volume 17, Issue 4, 2022
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Ethnomedicinal Plant Stephania hernandifolia and its Active Fraction 2- Chloroethyl Linoleate Inhibits HSV-2 Infection by Blocking Viral Immediate Early and Early Transcription
Aims: The aim of this study is validation of antiviral activity of Stephania hernandifolia against HSV-2. Background: Ethnomedicinal plant Stephania hernandifolia, traditionally used for the management of skin, digestive and nerve ailments demonstrated significant anti-HSV-1 activity; similar to Stephania cepharantha having neuroinflammatory and anti-HSV activities. Objectives: Thus, the present study aimed to validate the pot Read More
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Local Delivery of Metronidazole-loaded N-Trimethyl Quaternary Ammonium Chitosan Nanoparticles for Periodontitis Treatment
Authors: Kritika Garg and Pravin TirgarBackground: Recent findings suggest that chitosan has shown antibacterial activity acting through various mechanisms, but when the amine group in chitosan is converted to quaternary ammonium compound, the antibacterial activity of chitosan is elevated due to the increase in its solubility in an acidic environment. Objectives: The purpose of this study was to formulate and standardize metronidazole-loaded Ntrimethyl quater Read More
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Formulation Development and Optimization of Blonanserin Liquid SMEDDS using D-Optimal Mixture Design
Authors: Sohansinh Vaghela, Sunita Chaudhary and Ankit ChaudharyBackground: Blonanserin is an atypical antipsychotic potent antagonist of dopamine-D2 and D3 receptors with low aqueous solubility BCS class II drugs. Objective: The present research aims to develop and optimize the Blonanserin-loaded liquid selfmicro emulsifying drug delivery system (SMEDDS) to improve its in vitro drug release by D-optimal mixture design. Methods: Saturation solubility of Blonanserin was checked in Read More
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The Anticonvulsant Activity of Thiamine, Vitamin D3, and Melatonin Combination on Pentylenetetrazole-induced Seizures in Mice
Authors: Saeed Mehrzadi, Ehsan Dehdashtian, Mohammad Y. Karimi and Azam HosseinzadehObjective: Epilepsy is a neurological disorder associated with the elevation of oxidative stress levels and alteration in vitamins and endogenous antioxidant levels. The current study was designed to evaluate the effects of Vit D3, thiamine, melatonin, and their combination on pentylenetetrazol (PTZ)-induced tonic-clonic seizures in mice along with measuring the alteration in oxidative stress markers. Methods: Read More
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Pain Management with Topical Aceclofenac Nanosuspension In-Vitro/In- Vivo and Proof of Concept Studies
Authors: Shaina Nagpal, Parina Kumari, Komal Saini and Vandita KakkarIntroduction: Pain is one of the most common medical conditions and affects more than diabetes, heart disease, and cancer combined. Current pain treatments mainly rely on NSAID analgesics and remain unsatisfactory. Due to associated adverse effects such as gastrointestinal ulcers and bleeding, low solubility limits its use. Objective: The present research focuses on advances in the field of pain treatment by topical delive Read More
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Volumes & issues
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Volume 20 (2025)
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Volume 19 (2024)
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Volume 18 (2023)
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Volume 17 (2022)
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Volume 16 (2021)
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Volume 15 (2020)
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Volume 14 (2019)
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Volume 13 (2018)
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Volume 12 (2017)
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Volume 11 (2016)
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Volume 10 (2015)
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Volume 9 (2014)
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Volume 8 (2013)
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Volume 7 (2012)
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Volume 6 (2011)
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Volume 5 (2010)
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Volume 4 (2009)
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Volume 3 (2008)
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Volume 2 (2007)
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Volume 1 (2006)
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