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image of A  Methodical  Review  of  Intranasal  Delivery  of Nanocarriers for the Treatment of Glioblastoma: An Emerging Therapeutic Option

Abstract

Glioblastoma multiforme (GBM) is responsible for about half of all primary malignant tumors in the central nervous system (CNS). Nanotechnology and nanocarrier-based drug delivery may prove to be an asset in the ongoing fight against the difficulties associated with treating GBM. Obstacles to effective drug delivery in GBM treatment include prolonged blood circulation, sufficient BBB transit, effective internalization, and controlled drug release within GBM cells. By virtue of the non-specific and non-targeted character of anti-tumor medicines, the efficiency of medication delivery to gliomas is still impoverished. Glioma diagnosis and therapy have undergone a paradigm change solely because of nanotechnology. The highly invasive nature of this malignant glioma makes surgical resection a challenging procedure, and the current approved standard of care—follow-up radiation therapy with concurrent temozolomide (TMZ)—will only prolong the lifespan of patients by a few months. Drug delivery nanosystems (DDNSs) have garnered attention in the treatment of cancer, particularly gastrointestinal cancer, according to recent studies. This is because DDNPs have proven to be effective substitutes for conventional formulations currently on the market, in addition to optimizing the delivery of drugs to neoplastic cells, ameliorating the profile of toxicity and unfavorable effects, and reducing the overall harmful effects of formulations that include antineoplastic agents. Specifically, nanocarriers have proven to have an exceptional ability to get over the difficulties to achieve drug accumulation in the brain without going through the system delivering by IN route. Pre-clinical research on polymeric nanocarriers for treating GBM is ongoing, with few drug delivery systems entering clinical trials. This study examines nanoparticle forms, and brain tumor statistics, and summaries the diagnosis and treatment of GBM utilizing nanotechnology.

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2024-11-15
2024-12-27

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/content/journals/cdth/10.2174/0115748855323933241031181603
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A  Methodical  Review  of  Intranasal  Delivery  of Nanocarriers for the Treatment of Glioblastoma: An Emerging Therapeutic Option
Bentham Science Publishers ; https://doi.org/10.2174/0115748855323933241031181603
/content/journals/cdth/10.2174/0115748855323933241031181603
/content/journals/cdth/10.2174/0115748855323933241031181603
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  • Article Type:     Review Article
Keywords: Nanoparticles ; glioblastoma multiforme ; intranasal ; drug delivery

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