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Current Chinese Science - Current Issue

Volume 4, Issue 4

Volume 4, Issue 4, 2024

  • Section: Artificial Intelligence and Robotics

      • Electromagnetic Slime Sentinels: Transforming Drug Delivery, Object Extraction, and Healing Innovations

        https://doi.org/10.2174/0122102981349797241125092351

        Magnetic small soft-bodied robots are perfect for targeted medication administration, micromanipulation, and minimally invasive surgery because they provide non-invasive access to confined locations. Presently available magnetically operated small soft robots are based on elastomers (silicone) and fluids, such as ferrofluid or liquid metal; however, they have certain drawbacks. Robots built on elastomers have trouble deforming, which makes it challenging for them to maneuver in extremely constrained spaces. Although they may deform more easily, fluid-based robots have unstable forms and limited environmental adaptation. The non-Newtonian fluid-based magnetically actuated slime robots shown in this work combine the notable deformation capabilities of fluid-based robots with the flexibility of elastomer-based robots. These slime robots can move on different surfaces in intricate surroundings and navigate tiny channels as little as 1.5 mm in diameter. They can carry out various tasks, including transporting, ingesting, and gripping solid items, and also adapt to various surfaces. This review discusses the design, preparation, and applications of magnetic slime robots, highlighting their potential in revolutionizing biomedical operations, It also states about the stability among different atmospheric condition making it a new age of targeted drug delivery system and predicting various inovations and concepts about the magentic slime robot.

  • Section: Medicinal Chemistry

      • Evaluation of Novel Quinoline Derivatives Targeting Hepatocyte Growth Factor Receptors as Anticancer Agents

        https://doi.org/10.2174/0122102981320470240909113147
        Background

        Numerous methods for computer-aided drug design (CAAD) have made it possible to create and synthesize new chemical entities. The utilization of techniques and structure-based drug design (SBDD) facilitate the visualization of the ligand-target binding process, in addition to allowing the prediction of receptor affinities and important binding pocket locations.

        Objective

        The current research work was carried out to recognize novel quinoline derivatives designed specifically to bind with hepatocyte growth factor (HGF) receptors.

        Materials and Methods

        For the formation of quinolines derivatives, ChemAxon Marvin Sketch 5.11.5 was utilized. SwissADME and the admetSAR online web tools were exploited to predict the pharmacokinetic properties and the toxicity of compounds. Numerous software, including Autodock 1.5.7, MGL Tools 1.5.7, Biovia Discovery Studio Visualizer v20.1.0.19295, Procheck, Protparam tool, and PyMOL, were also used to determine the ligand-receptor interactions of derivatives of quinoline with the target receptor (PDB -1R0P).

        Results

        Based on research, it was found that all compounds were less toxic, orally bioavailable, and had the proper pharmacokinetic properties. When compared to the commonly used drug gefitinib, the docking scores of all newly created derivative compounds were higher.

        Conclusion

        An increased binding energy, the number of H-bonds generated, and interactions with quinoline analogues are significant parameters to be considered while constructing compounds that are most appropriate for additional investigation. The favorable pharmacokinetic profile of quinoline moiety was found to enhance its potential as a novel lung cancer treatment alternative and may help medicinal chemists to carry out more thorough , , chemical, and pharmacological research studies.

    • Quinoline Derivative Green Synthesis: Unveiling Anticancer Potential through Synergistic Insights and Molecular Docking Analysis

      https://doi.org/10.2174/0122102981332978240909103213
      Aim

      Synthesis and characterization of quinoline derivatives as an anticancer agent green chemistry approach and their molecular docking.

      Background

      In comparison to classical synthesis, green chemistry is a powerful tool for the more affordable and ecologically benign synthesis of organic molecules, such as quinoline derivatives an efficient base-mediated/metal-free approach.

      Objective

      The primary objective of the work presented in this article was to prepare -(2-(-butylamino)-1-(2-chloro-5,7-dimethylquinolin-3-yl)-2-oxoethyl)-3-methoxy--phenylbenzamide derivatives single-step Multicomponent Reaction. Characterized it, docking it, and their anticancer activities against different cell lines are evaluated.

      Methods

      In a sealed glass vial, one of the starting materials 2-chloro-5-7-dimethylquinoline-3-carbaldehyde was synthesized by the Vilsmeier-hack reaction. Substituted N-(2-(tert-butylamino)-1-(2-chloro-5,7-dimethylquinolin-3-yl)-2-oxoethyl)-3-methoxy-N-phenylbenzamide were obtained by the Ugi-Multi Component reaction of 2-chloro-5-7-dimethylquinoline-3-carbaldehyde , aniline , 3-methoxybenzoic acid and t-butyl isocyanides were dissolved sequence vise in 2,2,2-trifluoroethanol (TFE) reaction solvent. This method is an efficient base-mediated/metal-free approach to synthesizing quinoline derivatives.

      Results

      We have successfully synthesized the quinoline derivatives Ugi-multicomponent reaction an efficient base-mediated/metal-free approach. The structures of the compounds were confirmed through various spectroscopic techniques. Characterized it, docking it, and their anticancer activities against different cell lines are evaluated.

      Conclusion

      The reported protocol is advantageous over conventional methods of quinoline derivatives an efficient base-mediated/metal-free approach. Quinoline derivatives were tested for anticancer efficacy against 9 distinct subpanels of NCI-60 cell lines among which and have been found to be more potent against different cell lines. In order to get mechanistic insights into this antitumor activity, molecular docking analysis against critical target was performed to aid in understanding the molecular basis of anticancer activity. The results of binding affinity were in harmony with the anticancer activity providing valuable insights into the various thermodynamic interactions governing the binding affinity. By using the potential of quinoline derivatives an efficient base-mediated/metal-free approach, more effective and accurate cancer treatments can be designed in the future.

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