Current Chinese Science - Volume 4, Issue 1, 2024

Designing innovative one-pot reactions using eco-friendly methodologies has attracted a lot of attention in drug development, organic synthesis, and material sciences due to the impressive art of mitigating the possibility of side reactions, particularly for the synthesis of Ncontaining heterocycles, which are crucial for the manufacturing and development of new drugs. These moieties have demonstrated a diversity of Read More

The top taxonomic position among non-chordate invertebrates, which make up the evolutionary connection between invertebrates and vertebrates, is held by echinoderms. Their immune responses rely on coelomocyte activity functioning concurrently with a range of humoral components that directly interact with invasive pathogens. However, markedly lower numbers of systematic reviews of the classification Read More

Background: A thin membrane capsule covers the eye lens and links the lens and the applied forces by the ciliary muscles. The capsule converts the tension of the concentrated zonules to distributed surface tractions over the cortex surface during the lens accommodation. The gradual changes of the capsule geometry and material properties with age and its important role in the design of intraocular lens implants were Read More

Objective: The study aimed to discuss the possible mechanisms of Houpu Wenzhong Decoction in the treatment of chronic gastritis and depression based on network pharmacology and molecular docking. Methods: The chemical components and corresponding targets of seven crude drugs in Houpu Wenzhong Decoction were retrieved from the database TCMSP. The targets for treating chronic gastritis and depression were obt Read More

Background: Clear cell renal carcinoma (ccRCC) is one of the most common urological tumors worldwide and metabolic reprogramming is its distinguishing feature. A systematic study on the role of the metabolism-related genes in ccRCC cancer stem cells (CSCs) is still lacking. Moreover, an effective metabolism-related prediction signature is urgently needed to assess the prognosis of ccRCC patients. Methods: Gene expre Read More