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Volume 4, Issue 4
  • ISSN: 2210-2981
  • E-ISSN: 2210-2914

Abstract

Aim

Synthesis and characterization of quinoline derivatives as an anticancer agent green chemistry approach and their molecular docking.

Background

In comparison to classical synthesis, green chemistry is a powerful tool for the more affordable and ecologically benign synthesis of organic molecules, such as quinoline derivatives an efficient base-mediated/metal-free approach.

Objective

The primary objective of the work presented in this article was to prepare -(2-(-butylamino)-1-(2-chloro-5,7-dimethylquinolin-3-yl)-2-oxoethyl)-3-methoxy--phenylbenzamide derivatives single-step Multicomponent Reaction. Characterized it, docking it, and their anticancer activities against different cell lines are evaluated.

Methods

In a sealed glass vial, one of the starting materials 2-chloro-5-7-dimethylquinoline-3-carbaldehyde was synthesized by the Vilsmeier-hack reaction. Substituted N-(2-(tert-butylamino)-1-(2-chloro-5,7-dimethylquinolin-3-yl)-2-oxoethyl)-3-methoxy-N-phenylbenzamide were obtained by the Ugi-Multi Component reaction of 2-chloro-5-7-dimethylquinoline-3-carbaldehyde , aniline , 3-methoxybenzoic acid and t-butyl isocyanides were dissolved sequence vise in 2,2,2-trifluoroethanol (TFE) reaction solvent. This method is an efficient base-mediated/metal-free approach to synthesizing quinoline derivatives.

Results

We have successfully synthesized the quinoline derivatives Ugi-multicomponent reaction an efficient base-mediated/metal-free approach. The structures of the compounds were confirmed through various spectroscopic techniques. Characterized it, docking it, and their anticancer activities against different cell lines are evaluated.

Conclusion

The reported protocol is advantageous over conventional methods of quinoline derivatives an efficient base-mediated/metal-free approach. Quinoline derivatives were tested for anticancer efficacy against 9 distinct subpanels of NCI-60 cell lines among which and have been found to be more potent against different cell lines. In order to get mechanistic insights into this antitumor activity, molecular docking analysis against critical target was performed to aid in understanding the molecular basis of anticancer activity. The results of binding affinity were in harmony with the anticancer activity providing valuable insights into the various thermodynamic interactions governing the binding affinity. By using the potential of quinoline derivatives an efficient base-mediated/metal-free approach, more effective and accurate cancer treatments can be designed in the future.

© 2024 Bentham Science Publishers
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2024-09-25
2025-05-06

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Quinoline Derivative Green Synthesis: Unveiling Anticancer Potential through Synergistic Insights and Molecular Docking Analysis
Curr Chin Sci 4, 276 (2024); https://doi.org/10.2174/0122102981332978240909103213
/content/journals/ccs/10.2174/0122102981332978240909103213
/content/journals/ccs/10.2174/0122102981332978240909103213
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  • Article Type:     Research Article
Keyword(s): anticancer; Heterocyclic Chemistry; medicinal chemistry; molecular docking; NCI-60 cell line; quinoline derivatives; Ugi-4CC condensation
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