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Phytoextracts as Natural Anti-Aging Agents: Mechanisms and Strategies for Skin Rejuvenation
Authors: Vishakha Devi, Geeta Deswal, Ajmer Singh Grewal, Anjali Sharma and Kumar GuarveAvailable online: 03 March 2025More LessIntroduction Skin aging is a complex biological process driven by intrinsic factors, such as genetics and cellular metabolism, and extrinsic factors, including environmental stressors like UV radiation, pollution, and lifestyle choices. These factors result in visible signs of aging, such as wrinkles, reduced skin elasticity, and pigmentation. Objective This review presents the recent findings on phytoextracts as natural anti-aging agen Read More
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Unraveling the Memory of Falls in Older Adults: A Scoping Review
Authors: Karim Gallouj, Emin Altintas and Mohamad El HajAvailable online: 21 February 2025More LessDespite abundant research on falls in older adults, studies on the memory of falls are rare. Important issues not yet addressed include how older adults remember falls and whether these memories shape their life stories. Hence, a review was carried out in line with PRISMA guidelines. The present paper describes the MEMFA (MEMory of Falls in Aging) hypothesis, which we formulated to explain why older adults successfully i Read More
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AI-Driven Innovations in Hearing Health: A Review of Artificial Intelligence Applications in Audiology and Hearing Technologies
Authors: S. Chitra Thara, K. Vidhya Lekshmi and N. VenkateswaramurthyAvailable online: 11 February 2025More LessHearing loss is a prevalent condition affecting over 500 million people globally, with projections estimating more than 700 million cases by 2050. Artificial intelligence (AI) holds transformative potential in audiology, enhancing diagnostic, therapeutic, and rehabilitation outcomes. This review explores the applications of AI in hearing aids, cochlear implants, sign language recognition, and tele-audiology. A comprehensive literat Read More
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Peptide Regulation of Ageing: From Experiment to Practice
Authors: A.V. Arutjunyan, I.G. Popovich, L.S. Kozina and G.A. RyzhakAvailable online: 06 February 2025More LessThe article presents an analysis of the results of many years of research devoted to the study of biological activity of peptide bioregulators at the molecular, cellular and tissue levels, as well as at the level of the organism. The study of peptide efficacy and analysis of their mechanism of action allowed the famous Russian gerontologist Vladimir Khavinson to propose the concept of peptide regulation of gene expression and prote Read More
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Recent Advances in Bioactive Flavonoids-based Nanotherapeutics as Promising Neuroprotectants in Epilepsy
Available online: 27 January 2025More LessBackground Epilepsy is a prevalent neurological disorder that can be characterized by seizures and can be caused by abnormal electrical impulses in the brain. Various genetic, environmental, age-related, and lifestyle factors are associated with its pathogenesis, which causes neuronal cells to degenerate over time. Methodology Epilepsy often results from an imbalance between excitatory neurotransmitters, such as glutamate, Read More
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Uncovering the Healing Power of Stem Cells: Harnessing Regenerative Therapies for Alzheimer's Disease
Available online: 20 January 2025More LessAlzheimer's disease is a progressive neurodegenerative disorder with no known treatment. Recent advances in regenerative medicine, including stem cell therapies, hold promise for treating Alzheimer's disease and slowing its progression. This review explores the various types of stem cells, such as neural and mesenchymal stem cells, and how they can be harnessed for Alzheimer's treatment. It also discusses the potential Read More
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The Therapeutic Potential of Targeting the Pd-L1/Pd-1 Immune Checkpoint Pathway in Alzheimer's Disease
Available online: 06 December 2024More LessAlzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-β plaques, neurofibrillary tangles, and chronic neuroinflammation. Emerging evidence suggests that the PD-L1/PD-1 immune checkpoint pathway plays a critical role in modulating neuroinflammation, microglial function, and amyloid-β clearance in AD. This review summarizes the current understanding o Read More
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Prevalence of Sarcopenic Obesity in Elderly Population: A Meta-Analysis
Available online: 03 December 2024More LessBackground Sarcopenic obesity (SO) is characterized by the simultaneous presence of both obesity and sarcopenia in the same individual, and it is associated with adverse health outcomes such as falls, hospitalization, functional disability, and mortality. This study aimed to provide a comprehensive analysis of the prevalence of SO in the elderly population through a systematic review and meta-analysis of the scientifi Read More
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New Insights into Colorectal Cancer through the Lens of Precision Oncology and Personalized Medicine: Multi-Omics Helps Aging of Predisposed People
Available online: 05 November 2024More LessBackground Recently, there has been a significant evolution in our understanding of the molecular pathways causing the genesis and progression of cancer via the inter-individual variations. Thus, one-size-fits-all methods for cancer treatment have been replaced by precision oncology (PO) targeting individual cancer symptoms, offering increased effectiveness, and decreased safety concerns and cost load. Objective The ide Read More
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A Bibliometric Analysis of Research Trends in Aging and Leisure Activities from 2000 to 2023
Authors: J Mufina Begam and E P. Abdul AzeezAvailable online: 16 October 2024More LessBackground Physical and leisure activities are vital for active aging. Leisure activities among the aging population have received attention from scholars in the recent past. However, the research contributions and trends in this field are unknown. Therefore, a bibliometric analysis was conducted to explore the scholarly contributions in aging and leisure activities to identify the research output trends, assess thematic fo Read More
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Shorter Telomere Length is Associated with Food Insecurity in Older People: A Cross-Sectional Study
Available online: 09 October 2024More LessBackground Telomere length has been investigated as a biomarker of biological aging and is associated with several diseases, lifestyle, and socioeconomic factors. Objective This study aimed to verify whether food insecurity is associated with shorter telomere length in older people. Methods This is a cross-sectional study carried out in a municipality in the interior of Brazil, with a sample of 440 older people from the c Read More
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Nicotinamide Adenine Dinucleotide (NAD)-Dependent Protein Deacetylase, Sirtuin, as a Biomarker of Healthy Life Expectancy: A Mini-Review
Authors: Yodo Sugishita, Yuki Suzuki-Takahashi and Kazuo YudohAvailable online: 08 October 2024More LessAlthough a variety of disease-specific biomarkers have been identified for common lifestyle- or aging-related diseases, there are currently no indices available to measure general health or the existence of pre-symptomatic conditions in various types of tissue and organ damage. A rising body of research suggests that sirtuins may have the potential to be used as an index to assess overall health status and the existence o Read More
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Variability in Exercise is Linked to Improved Age-related Dysfunctions, Suggesting a Potential Role for the Constrained-Disorder Principle-based Second-Generation Artificial Intelligence System
Authors: Ehud Rinott, Tal Sigawi, Noa Hurvitz, Narmin Elkhateeb, Lilah Rinsky-Halivni and Yaron IlanAvailable online: 20 January 2024More LessObjectiveRegular physical activity (PA) promotes mental and physical health. Nevertheless, inactivity is a worldwide pandemic, and methods to augment exercise benefits are required. The constrained disorder principle (CDP) characterizes biological systems based on their inherent variability. Therefore, we aimed to investigate the association between intra-individual variability in PA and disability among non-athlete Read More
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Polyphenols and Aging
Authors: Brannon L. Queen and Trygve O. Tollefsbol
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