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Current Aging Science - Online First
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The Therapeutic Potential of Targeting the Pd-L1/Pd-1 Immune Checkpoint Pathway in Alzheimer's Disease
Available online: 06 December 2024More LessAlzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-β plaques, neurofibrillary tangles, and chronic neuroinflammation. Emerging evidence suggests that the PD-L1/PD-1 immune checkpoint pathway plays a critical role in modulating neuroinflammation, microglial function, and amyloid-β clearance in AD. This review summarizes the current understanding of the PD-L1/PD-1 pathway in AD and discusses its potential as a therapeutic target. Preclinical studies and clinical trials have demonstrated that targeting the PD-L1/PD-1 axis can enhance microglial phagocytosis, promote amyloid-β clearance, and reduce neuroinflammation. We examine the potential benefits and challenges of using existing immunotherapy drugs, such as anti-PD-L1 and anti-PD-1 antibodies, in the context of AD.
Additionally, we explore the development of novel, more specific agents targeting the PD-L1/PD-1 pathway, as well as potential synergistic approaches with other immunomodulatory or amyloid-β-targeting treatments. This review provides a comprehensive and up-to-date analysis of the PD-L1/PD-1 immune checkpoint pathway's role in Alzheimer's disease, highlighting its promising therapeutic potential for improving patient outcomes. Further research is warranted to optimize treatment strategies and evaluate the long-term safety and efficacy of targeting this axis in clinical settings.
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Prevalence of Sarcopenic Obesity in Elderly Population: A Meta-Analysis
Available online: 03 December 2024More LessBackgroundSarcopenic obesity (SO) is characterized by the simultaneous presence of both obesity and sarcopenia in the same individual, and it is associated with adverse health outcomes such as falls, hospitalization, functional disability, and mortality. This study aimed to provide a comprehensive analysis of the prevalence of SO in the elderly population through a systematic review and meta-analysis of the scientific literature.
MethodsA systematic search was conducted in the PubMed, Embase, Web of Science, and LILACS databases for observational studies published up to July 2023 on the prevalence of SO in individuals aged 65 years or older. Data were collected from the selected and included articles, including general study information, demographic characteristics of the samples, methods, and results. The quality of the studies was assessed using the Newcastle-Ottawa Scale (NOS) criteria. A random-effects model was applied for the quantitative synthesis (meta-analysis) of combined prevalence data, and the I-squared index (I2) was used to assess heterogeneity. Publication bias was evaluated using a funnel plot and Egger’s test.
ResultsA total of 37 articles meeting the eligibility criteria were selected and included in this meta-analysis. Heterogeneity among the studies was observed, along with evidence of publication bias. Most studies were classified as having a high risk of bias. The pooled prevalence of SO in the elderly was 10% (95% CI: 8%−12%; I2: 99.10%, p<0.001). A similar result was observed after stratification by sex, with a prevalence of 10% in both men (95% CI: 8%−12%; I2: 97.46%, p<0.001) and women (95% CI: 8%−12%; I2: 98.72%, p<0.001). Subgroup and sensitivity analyses revealed that the study setting, criteria used for the diagnosis of obesity, and the risk of bias in the studies were potential factors contributing to the heterogeneity in the prevalence of SO in the elderly.
ConclusionsThis meta-analysis indicated a significant prevalence of SO among the elderly population, with no difference by sex, highlighting SO as a substantial health problem in this population. These findings underscore the importance of interventions to reduce the occurrence of SO in the elderly.
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New Insights into Colorectal Cancer through the Lens of Precision Oncology and Personalized Medicine: Multi-Omics Helps Aging of Predisposed People
Available online: 05 November 2024More LessBackgroundRecently, there has been a significant evolution in our understanding of the molecular pathways causing the genesis and progression of cancer via the inter-individual variations. Thus, one-size-fits-all methods for cancer treatment have been replaced by precision oncology (PO) targeting individual cancer symptoms, offering increased effectiveness, and decreased safety concerns and cost load.
ObjectiveThe identification of novel actionable indications, rapid, precise, and comprehensive detection of complex phenotypes in every individual, pioneering clinical trial projects with enhanced response feedback, and widespread availability of innovative targeted anticancer management for every patient are vital for the effective implementation of next-generation precision oncology. Additionally, the emergence of precision medicine has altered the perspective of oncologic biomarkers, drug discovery, drug development, and, improvements for cancer patients.
MethodThis paper narratively reviewed to identify actionable abnormalities, Genomic profiling of tumors employing clinical next-generation sequencing (NGS) from both tumor tissues and liquid biopsies along with the multi-omics strategies as the key component of PO.
ResultsOur increasing information on tumor biology, specifically microenvironment and heterogeneity-associated data, would improve our understanding of the resistance of targeted drugs and specific mechanisms of action, as well as help enhance existing metastatic colorectal cancer (mCRC) treatment strategies.
ConclusionCollectively, this paper indicated the current and innovative strategies for prognosis, diagnosis, and treatment of various cancer types based on PO overview with a groundbreaking emphasis on CRC suggesting the integrations of multi-omics, highlighting Genomics, and utilizing AL and ML algorithms with targeted therapies. Notably, these findings can help improve the life-span and ageing of the predisposed people.
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A Bibliometric Analysis of Research Trends in Aging and Leisure Activities from 2000 to 2023
Authors: J Mufina Begam and E P. Abdul AzeezAvailable online: 16 October 2024More LessBackgroundPhysical and leisure activities are vital for active aging. Leisure activities among the aging population have received attention from scholars in the recent past. However, the research contributions and trends in this field are unknown. Therefore, a bibliometric analysis was conducted to explore the scholarly contributions in aging and leisure activities to identify the research output trends, assess thematic focuses, and analyze research collaboration patterns.
MethodsWe extracted data from the Scopus database for the period 2000-2023 and identified 443 articles focusing on aging and leisure activities. Tools, such as bibliographical coupling networks and thematic analysis, were applied using R and Biblioshiny to uncover core themes and connections.
ResultsThere has been a significant increase in research output since 2021, with contributions from numerous authors and countries, particularly the United States and China. Thematic analysis reveals central themes, such as physical activity, successful aging, and cognition.
ConclusionThis analysis reveals the evolving nature of scholarly discussions in aging and leisure, highlighting key themes, such as physical activity, cognitive aging, and health promotion. The findings emphasize the growing interest and global collaboration in this interdisciplinary research domain.
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Shorter Telomere Length is Associated with Food Insecurity in Older People: A Cross-Sectional Study
Available online: 09 October 2024More LessBackgroundTelomere length has been investigated as a biomarker of biological aging and is associated with several diseases, lifestyle, and socioeconomic factors.
ObjectiveThis study aimed to verify whether food insecurity is associated with shorter telomere length in older people.
MethodsThis is a cross-sectional study carried out in a municipality in the interior of Brazil, with a sample of 440 older people from the community. For telomere length analysis, a blood sample was obtained from each participant, followed by real-time qPCR, and sociodemographic and health information was collected through interviews. Food security/insecurity was measured using the reduced version of the Brazilian Food Insecurity Scale. Descriptive analysis and multiple logistic regression were performed to analyze the factors associated with shorter telomere length, adopting a significance level of 5%.
ResultsWe found that food insecurity was significantly associated with shorter telomere length, regardless of age group, skin color, tabagism, physical activity, milk and dairy consumption, living arrangement, and basic activities of daily life.
ConclusionThe findings show the importance of ensuring full access to adequate nutrition for the older population, who are physiologically and socially vulnerable.
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Nicotinamide Adenine Dinucleotide (NAD)-Dependent Protein Deacetylase, Sirtuin, as a Biomarker of Healthy Life Expectancy: A Mini-Review
Authors: Yodo Sugishita, Yuki Suzuki-Takahashi and Kazuo YudohAvailable online: 04 October 2024More LessAlthough a variety of disease-specific biomarkers have been identified for common lifestyle- or aging-related diseases, there are currently no indices available to measure general health or the existence of pre-symptomatic conditions in various types of tissue and organ damage. A rising body of research suggests that sirtuins may have the potential to be used as an index to assess overall health status and the existence of pre-symptomatic illness states. Sirtuins (SIRTs) are nicotinamide adenine dinucleotide (NAD)-dependent deacetylases expressed in a variety of human somatic cells both in health and disease conditions. The activity and expression of SIRTs affect important metabolic pathways, such as cell survival, senescence, proliferation, energy production, stress tolerance, DNA repair, and apoptosis, thereby closely linked to aging and longevity. Given the broad significance of SIRTs in physiological function maintenance, their activity in somatic cells may reflect the early cross-sectional status of tissue damage caused by aging or systemic inflammatory responses that are too early to be detected by disease-specific biomarkers. In this mini-review, we discuss the utility of SIRTs as a surrogate clinical biomarker for health status to evaluate and monitor health life expectancy and the presence of pre-symptomatic illness states.
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Polyphenols and Aging
Authors: Brannon L. Queen and Trygve O. Tollefsbol
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