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2000
Volume 18, Issue 3
  • ISSN: 1874-6098
  • E-ISSN: 1874-6128

Abstract

Background

Telomere length has been investigated as a biomarker of biological aging and is associated with several diseases, lifestyle, and socioeconomic factors.

Objective

This study aimed to verify whether food insecurity is associated with shorter telomere length in older people.

Methods

This is a cross-sectional study carried out in a municipality in the interior of Brazil, with a sample of 440 older people from the community. For telomere length analysis, a blood sample was obtained from each participant, followed by real-time qPCR, and sociodemographic and health information was collected through interviews. Food security/insecurity was measured using the reduced version of the Brazilian Food Insecurity Scale. Descriptive analysis and multiple logistic regression were performed to analyze the factors associated with shorter telomere length, adopting a significance level of 5%.

Results

We found that food insecurity was significantly associated with shorter telomere length, regardless of age group, skin color, tabagism, physical activity, milk and dairy consumption, living arrangement, and basic activities of daily life.

Conclusion

The findings show the importance of ensuring full access to adequate nutrition for the older population, who are physiologically and socially vulnerable.

This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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2024-10-09
2026-02-19
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References

  1. Castro-DiehlC. EhrbarR. ObasV. OhA. VasanR.S. XanthakisV. Biomarkers representing key aging-related biological pathways are associated with subclinical atherosclerosis and all-cause mortality: The Framingham Study.PLoS One2021165e025130810.1371/journal.pone.0251308 33989340
    [Google Scholar]
  2. DongX. SunS. ZhangL. KimS. TuZ. MontagnaC. Age-related telomere attrition causes aberrant gene expression in sub-telomeric regions.Aging Cell2021206e1335710.1111/acel.13357
    [Google Scholar]
  3. GalkinF. MamoshinaP. AliperA. de MagalhaesJ.P. GladyshevV.N. ZhavoronkovA. Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities.Ageing Res. Rev.202060101050
    [Google Scholar]
  4. FosselM. Use of telomere length as a biomarker for aging and age-related disease.Curr. Transl. Geriatr. Exp. Gerontol. Rep.20121212112710.1007/s13670‑012‑0013‑6
    [Google Scholar]
  5. RentscherK.E. CarrollJ.E. MitchellC. Psychosocial stressors and telomere length: A current review of the science.Annu. Rev. Public Health202041122324510.1146/annurev‑publhealth‑040119‑094239 31900099
    [Google Scholar]
  6. SmithL. LuchiniC. DemurtasJ. Telomere length and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.Ageing Res. Rev.20195111010.1016/j.arr.2019.02.003 30776454
    [Google Scholar]
  7. BalanE. DecottigniesA. DeldicqueL. Physical activity and nutrition: Two promising strategies for telomere maintenance?Nutrients20181012194210.3390/nu10121942 30544511
    [Google Scholar]
  8. MartiA. Fernandez de la PuenteM. CanudasS. ZalbaG. RazquinC. Valle-HitaC. Effect of a 3-year lifestyle intervention on telomere length in participants from PREDIMED-Plus: A randomized trial.Clin. Nutr.202342915811587
    [Google Scholar]
  9. NormandoP. BezerraF.F. SantanaB.A. Association between socioeconomic markers and adult telomere length differs according to sex: Pro-Saúde study.Braz. J. Med. Biol. Res.20205311e1022310.1590/1414‑431x202010223 33053112
    [Google Scholar]
  10. RedePENSSAN II VIGISAN - Inquérito Nacional sobre Insegurança Alimentar no Contexto da Pandemia da Covid-19 no Brasil.São Paulo: Fundação Friedrich Ebert2022Report in Portuguese
    [Google Scholar]
  11. LerouxJ. CoxJ. RosenbergM. Food insecurity and aging: A scoping study of the literature.Can. J. Aging202039466269610.1017/S071498081900059X 31983352
    [Google Scholar]
  12. GalièS. CanudasS. MuralidharanJ. García-GavilánJ. BullóM. Salas-SalvadóJ. Impact of nutrition on telomere health: Systematic review of observational cohort studies and randomized clinical trials.Adv. Nutr.202011357660110.1093/advances/nmz107 31688893
    [Google Scholar]
  13. LeungC.W. FungT.T. McEvoyC.T. LinJ. EpelE.S. Diet quality indices and leukocyte telomere length among healthy us adults: data from the national health and nutrition examination survey, 1999–2002.Am. J. Epidemiol.2018187102192220110.1093/aje/kwy124 29912268
    [Google Scholar]
  14. TuckerL.A. Fruit and vegetable intake and telomere length in a random sample of 5448 U.S. adults.Nutrients2021135141510.3390/nu13051415 33922436
    [Google Scholar]
  15. LimaS.M. RenX. MuL. Ochs-BalcomH.M. PalermoT. Food Insecurity, telomere length and the potential modifying effects of social support in National Health and Nutrition Examination Survey.Public Health Nutr.202326123005301210.1017/S1368980023002008 37734859
    [Google Scholar]
  16. MazidiM. KengneA.P. VatanparastH. Food security and leukocyte telomere length in adult americans.Oxid. Med. Cell. Longev.201720171542765710.1155/2017/5427657 28951768
    [Google Scholar]
  17. FaulF. ErdfelderE. LangA.G. BuchnerA.G. *Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences.Behav. Res. Methods200739217519110.3758/BF03193146 17695343
    [Google Scholar]
  18. Brazil Estudo de estimativas populacionais por município, idade e sexo 2000-2020.Brasil. Brasil: Ministério da Saúde2020Report in Portuguese
    [Google Scholar]
  19. von ElmE. AltmanD.G. EggerM. PocockS.J. GøtzscheP.C. VandenbrouckeJ.P. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: Guidelines for reporting observational studies.Lancet200737095961453145710.1016/S0140‑6736(07)61602‑X 18064739
    [Google Scholar]
  20. GuigozY. VellasB. GarryP.J. Assessing the nutritional status of the elderly: The Mini Nutritional Assessment as part of the geriatric evaluation.Nutr. Rev.1996541S59S6510.1111/j.1753‑4887.1996.tb03793.x 8919685
    [Google Scholar]
  21. StiesS.W. GonzálesA.I. VianaM.S. BrandtR. BertinR.L. GoldfederR. Simplified nutritional appetite questionnaire (SNAQ) for cardiopulmonary and metabolic rehabilitation program.Rev. Bras. Med. Esporte2012185510.1590/S1517‑86922012000500006
    [Google Scholar]
  22. YesavageJ.A. SheikhJ.I. 9/geriatric depression scale (GDS) recent evidence and development of a shorter version.Clin. Gerontol.198651-216517310.1300/J018v05n01_09
    [Google Scholar]
  23. ParadelaE.M. LourençoR.A. VerasR.P. [Validation of geriatric depression scale in a general outpatient clinic]Rev. Saude Publica200539691892310.1590/S0034‑89102005000600008 16341401
    [Google Scholar]
  24. DamascenoA. DelicioA.M. MazoD.F.C. Validation of the Brazilian version of mini-test CASI-S.Arq. Neuropsiquiatr.2005632b41642110.1590/S0004‑282X2005000300010 16059591
    [Google Scholar]
  25. de OliveiraG.M. YokomizoJ.E. e SilvaL.S.V. SaranL.F. BottinoC.M.C. YassudaM.S. The applicability of the cognitive abilities screening instrument–short (CASI-S) in primary care in Brazil.Int. Psychogeriatr.2016281939910.1017/S1041610215000642 25921381
    [Google Scholar]
  26. KatzS. FordA.B. MoskowitzR.W. JacksonB.A. JaffeM.W. Studies of Illness in the Aged.JAMA19631851291491910.1001/jama.1963.03060120024016 14044222
    [Google Scholar]
  27. SantosL.P. LindemannI.L. MottaJ.V.S. MintemG. BenderE. GiganteD.P. Proposal of a short-form version of the Brazilian food insecurity scale.Rev. Saude Publica201448578378910.1590/S0034‑8910.2014048005195 25372169
    [Google Scholar]
  28. CawthonR.M. Telomere length measurement by a novel monochrome multiplex quantitative PCR method.Nucleic Acids Res.2009373e2110.1093/nar/gkn1027 19129229
    [Google Scholar]
  29. BarbosaA.R.C. NunesD.P. LimaD.B. Association of social support network with telomere length: A cross-sectional study with community-dwelling older adults.Rejuvenation Res.202225625325910.1089/rej.2022.0037 36103374
    [Google Scholar]
  30. LebrãoM.L. LaurentiR. Health, well-being and aging: The SABE study in São Paulo, Brazil.Rev. Bras. Epidemiol.2005821510.1590/S1415‑790X2005000200005
    [Google Scholar]
  31. MeloM.M.D.C. SouzaW.V. CoutoG.B.L. Comparison of multivariate regression methods in the study of determinants of dental caries in children.Rev. Bras. Saúde Mater. Infant.201414434335210.1590/S1519‑38292014000400004
    [Google Scholar]
  32. AraújoM.L. MendonçaR.D. Lopes FilhoJ.D. LopesA.C.S. Association between food insecurity and food intake.Nutrition201854545910.1016/j.nut.2018.02.023 29775834
    [Google Scholar]
  33. NaM. MehraS. ChristianP. Maternal dietary diversity decreases with household food insecurity in rural Bangladesh: A longitudinal analysis.J. Nutr.2016146102109211610.3945/jn.116.234229 27581578
    [Google Scholar]
  34. PanigassiG. Segall-CorrêaA.M. Marin-LeónL. Pérez-EscamillaR. MaranhaL.K. SampaioM.F.A. Intra-family food insecurity and profile of food consumption.Rev. Nutrição.2008211010.1590/S1415‑52732008000700012
    [Google Scholar]
  35. SantosA.L.B. GubertM.B. DeusA.C.S. Severe food insecurity is associated with risk factors for chronic noncommunicable diseases and cardiovascular disease in the Federal District. [Article in Portuguese DEMETRA: Food.Nutrição & Saúde201611413
    [Google Scholar]
  36. Household budget survey 2017-2018: Analysis of food security in Brazil.Rio de Janeiro: IBGE2020Report in Portuguese
    [Google Scholar]
  37. PaulL. Diet, nutrition and telomere length.J. Nutr. Biochem.2011221089590110.1016/j.jnutbio.2010.12.001
    [Google Scholar]
  38. National Institute of HealthNutrients Recommendations and Databases.USA: NIH, Office of Dietary Suplemments.
    [Google Scholar]
  39. AppanahG. ZareiM. QorbaniM. Food insecurity and dietary intake among elderly population: A systematic review.Int. J. Prev. Med.2021121810.4103/ijpvm.IJPVM_61_19 34084305
    [Google Scholar]
  40. VidačekN.Š. NanićL. RavlićS. Telomeres, nutrition, and longevity: Can we really navigate our aging?J. Gerontol. A Biol. Sci. Med. Sci.2018731394710.1093/gerona/glx082 28510637
    [Google Scholar]
  41. T M, Sulaiman KM, Drishti D, Srivastava S. Food insecurity and associated depression among older adults in India: evidence from a population-based study.BMJ Open2022124e05271810.1136/bmjopen‑2021‑052718 35440447
    [Google Scholar]
  42. PereiraM.H.Q. PereiraM.L.A.S. TelesB.K.A. CamposG.C. MolinaM.C.B. Food insecurity and depressive symptoms among older adults assisted by the Family Health Strategy in the Northeast region of Brazil.Rev. Nutr.202336e22019710.1590/1678‑9865202336e220197
    [Google Scholar]
  43. BrueningM. DinourL.M. ChavezJ.B.R. Food insecurity and emotional health in the USA: A systematic narrative review of longitudinal research.Public Health Nutr.201720173200320810.1017/S1368980017002221 28903785
    [Google Scholar]
  44. PourmotabbedA. MoradiS. BabaeiA. Food insecurity and mental health: A systematic review and meta-analysis – CORRIGENDUM.Public Health Nutr.20202310185410.1017/S1368980020001512 32364104
    [Google Scholar]
  45. OliveiraB.S. ZunzuneguiM.V. QuinlanJ. FahmiH. TuM.T. GuerraR.O. Systematic review of the association between chronic social stress and telomere length: A life course perspective.Ageing Res. Rev.201626375210.1016/j.arr.2015.12.006
    [Google Scholar]
  46. TravassosG.F. CoelhoA.B. Arends-KuenningM.P. The elderly in Brazil: Demographic transition, profile, and socioeconomic condition.Rev. Bras. Estud. Popul.20203728
    [Google Scholar]
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