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image of Recent Advances in Bioactive Flavonoids-based Nanotherapeutics as Promising Neuroprotectants in Epilepsy

Abstract

Background

Epilepsy is a prevalent neurological disorder that can be characterized by seizures and can be caused by abnormal electrical impulses in the brain. Various genetic, environmental, age-related, and lifestyle factors are associated with its pathogenesis, which causes neuronal cells to degenerate over time.

Methodology

Epilepsy often results from an imbalance between excitatory neurotransmitters, such as glutamate, and inhibitory neurotransmitters, such as GABA. Abnormalities in glutamate receptors like N-methyl-D-aspartate (NMDA), and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) can lead to excessive neuronal excitation, while dysfunctions in GABA receptors can result in insufficient inhibition, both of which can provoke seizures. Additionally, a variety of receptors and pathways like NF-κB, DAPK, Trκb, COX-2, . are associated with the expression of epilepsy. This disorder often faces various limitations in treatment with current anti-epileptic drugs (AEDs), such as drug resistance, adverse effects, and high costs. In context, flavonoids exhibit significant neuroprotective properties in epilepsy through various mechanisms such as antioxidant activity, anti-inflammatory effects, neurotransmitter systems, and receptor modulation.

Results

Flavonoids communicate with different signaling pathways and adjust their activities, prompting valuable neuroprotective impacts. Essential flavonoids such as quercetin, rutin, apigenin, luteolin, genistein, fisetin, chrysin, vitexin, naringin, baicalin, catechin, morin, hesperetin, kaempferol, gallic acid, silibinin, wogonin, . have shown promising results in channel regulation, reduced oxidative stress and neuroinflammation, and neuronal excitability in experimental models of epilepsy. Given their inherent neuroprotective properties and ability to modulate multiple pathways involved in epilepsy, flavonoids hold considerable promise as multitargeted, accessible, and low-cost alternatives to conventional AEDs. Although there are challenges with target specificity and bioavailability, innovative approaches such as nanotechnology and chemical modifications are being developed to enhance these aspects.

Conclusion

Focusing on the mechanisms of action and neuroprotective benefits the paper highlights the promising role of flavonoids and flavonoid-based nanotherapeutics as a beneficial addition to epilepsy treatment strategies.

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2025-03-27

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References

  1. Darehbagh R.R. Seyedoshohadaei S.A. Ramezani R. Rezaei N. Stem cell therapies for neurological disorders: Current progress, challenges, and future perspectives. Eur. J. Med. Res. 2024 29 1 386 10.1186/s40001‑024‑01987‑1 39054501
    [Google Scholar]
  2. Potnis V.V. Albhar K.G. Nanaware P.A. Pote V.S. A review on epilepsy and its management. J. Drug Deliv. Ther. 2020 10 3 273 279 10.22270/jddt.v10i3.4090
    [Google Scholar]
  3. Vezzani A. Fujinami R.S. White H.S. Preux P.M. Blümcke I. Sander J.W. Löscher W. Infections, inflammation and epilepsy. Acta Neuropathol. 2016 131 2 211 234 10.1007/s00401‑015‑1481‑5 26423537
    [Google Scholar]
  4. Devinsky O. Spruill T. Thurman D. Friedman D. Recognizing and preventing epilepsy-related mortality. Neurology 2016 86 8 779 786 10.1212/WNL.0000000000002253 26674330
    [Google Scholar]
  5. Kwon J.Y. Jeon M.T. Jung U.J. Kim D.W. Moon G.J. Kim S.R. Perspective: Therapeutic potential of flavonoids as alternative medicines in epilepsy. Adv. Nutr. 2019 10 5 778 790 10.1093/advances/nmz047 31111873
    [Google Scholar]
  6. Waris A. Ullah A. Asim M. Ullah R. Rajdoula M.R. Bello S.T. Alhumaydhi F.A. Phytotherapeutic options for the treatment of epilepsy: Pharmacology, targets, and mechanism of action. Front. Pharmacol. 2024 15 1403232 10.3389/fphar.2024.1403232 38855752
    [Google Scholar]
  7. Gilioli I. Vignoli A. Visani E. Casazza M. Canafoglia L. Chiesa V. Gardella E. Briola L.F. Panzica F. Avanzini G. Canevini M.P. Franceschetti S. Binelli S. Focal epilepsies in adult patients attending two epilepsy centers: Classification of drug‐resistance, assessment of risk factors, and usefulness of “new” antiepileptic drugs. Epilepsia 2012 53 4 733 740 10.1111/j.1528‑1167.2012.03416.x 22360822
    [Google Scholar]
  8. Amiri B. Tabrizi Y.M. Naziri M. Moradi F. Arzaghi M. Archin I. Behaein F. Pour B.A. Ghannadikhosh P. Imanparvar S. Kohneshahri A.A. Abbasi S.A. Zerangian N. Alijanzadeh D. Ghayyem H. Azizinezhad A. Youshanlui A.M. Poudineh M. Neuroprotective effects of flavonoids: Endoplasmic reticulum as the target. Front. Neurosci. 2024 18 1348151 10.3389/fnins.2024.1348151 38957188
    [Google Scholar]
  9. Liu Z. Lindemeyer A.K. Liang J. Wallner M. Shao X.M. Shao Y. Tao Y. Olsen R.W. Flavonoids isolated from Tibetan medicines, binding to GABAA receptor and the anticonvulsant activity. Phytomedicine 2018 50 1 7 10.1016/j.phymed.2018.09.198 30466968
    [Google Scholar]
  10. Dong H. Gao X. Li H. Gao J. Zhang L. Protective effects of flavonoids against intracerebral and subarachnoid hemorrhage (Review). Exp. Ther. Med. 2024 28 3 350 10.3892/etm.2024.12639 39071910
    [Google Scholar]
  11. Panche A.N. Diwan A.D. Chandra S.R. Flavonoids: An overview. J. Nutr. Sci. 2016 5 e47 10.1017/jns.2016.41 28620474
    [Google Scholar]
  12. Dajas F. Rivera-Megret F. Blasina F. Arredondo F. Abin-Carriquiry J.A. Costa G. Echeverry C. Lafon L. Heizen H. Ferreira M. Morquio A. Neuroprotection by flavonoids. Braz. J. Med. Biol. Res. 2003 36 12 1613 1620 10.1590/S0100‑879X2003001200002 14666245
    [Google Scholar]
  13. Vauzour D. Vafeiadou K. Rodriguez-Mateos A. Rendeiro C. Spencer J.P.E. The neuroprotective potential of flavonoids: A multiplicity of effects. Genes Nutr. 2008 3 3-4 115 126 10.1007/s12263‑008‑0091‑4 18937002
    [Google Scholar]
  14. Khare N. Tare H. Plants with potential neuropharmacological activity: Plant-based medicine for the brain. Inter. J. Pharm. Qua. Assu. 2024 15 1 523 530 10.25258/ijpqa.15.1.79
    [Google Scholar]
  15. Diniz T.C. Silva J.C. Lima-Saraiva S.R.G. Ribeiro F.P.R.A. Pacheco A.G.M. Freitas d.R.M. Quintans-Júnior L.J. Quintans J.S.S. Mendes R.L. Almeida J.R.G.S. The role of flavonoids on oxidative stress in epilepsy. Oxid. Med. Cell. Longev. 2015 2015 1 9 10.1155/2015/171756 25653736
    [Google Scholar]
  16. Movahedpour A. Taghvaeefar R. Asadi-Pooya A.A. Karami Y. Tavasolian R. Khatami S.H. Fard S.E. Taghvimi S. Karami N. Jaberi R.K. Taheri-Anganeh M. Ghasemi H. Nano‐delivery systems as a promising therapeutic potential for epilepsy: Current status and future perspectives. CNS Neurosci. Ther. 2023 29 11 3150 3159 10.1111/cns.14355 37452477
    [Google Scholar]
  17. Mukhopadhyay H. Kandar C. Das S. Epilepsy and its Management: A Review. J. Pharm. Sci. Technol. 2012 1 20 26
    [Google Scholar]
  18. Akyuz E. Polat A.K. Eroglu E. Kullu I. Angelopoulou E. Paudel Y.N. Revisiting the role of neurotransmitters in epilepsy: An updated review. Life Sci. 2021 265 118826 10.1016/j.lfs.2020.118826 33259863
    [Google Scholar]
  19. Sears S.M.S. Hewett S.J. Influence of glutamate and GABA transport on brain excitatory/inhibitory balance. Exp. Biol. Med. 2021 246 9 1069 1083 10.1177/1535370221989263 33554649
    [Google Scholar]
  20. Abani O. Abbas A. Abbas F. Abbas M. Abbasi S. Abbass H. Abbott A. Abdallah N. Abdelaziz A. Abdelfattah M. Abdelqader B. Abdul B. Rasheed A.A. Abdulakeem A. Abdul-Kadir R. Abdullah A. Abdulmumeen A. Abdul-Raheem R. Abdulshukkoor N. Abdusamad K. Abed El Khaleq Y. Abedalla M. Ul-Amna A. Abernethy K. Aboaba A. Abo-Leyah H. Abou-Haggar A. Abouibrahim M. Abraham M. Abraham T. Abraheem A. Abrams J. Abu H-J. Abu-Arafeh A. Abubacker S.M. Abung A. Aceampong Y. Achara A. Acharya D. Acheampong S. Acheson J. Acosta A. Acton C. Adabie-Ankrah J. Adam F. Adam M. Adamali H. Adams C. Adams C. Adams K. Adams R. Adams T. Adatia K. Adcock K. Adebiyi A. Adegoke K. Adell V. Adenwalla S. Adesemoye O.A. Adewunmi E.O. Adeyemi J. Adhikari B. Adhikary R. Adkins G. Adnan A. Aeron-Thomas J. Affleck D. Afnan C. Afridi M. Aftab Z.A. Agarwal M. Agbeko R. Agbo C. Aggarwal S. Aghababaie A. Sadiq A.S. Nazeer A.M.H. Ahmad M. Ahmad S. Ahmed A. Ahmed B. Ahmed F. Ahmed H. Ahmed I. Ahmed K. Ahmed L. Ahmed M. Ahmed M.C. Ahmed M.S. Ahmed N. Ahmed N. Ahmed O. Ahmed R.A. Ahmed R. Ahmed S. Ahmed S. Ahmed S. Ahmed S.H. Ali A.R. Ahmed S. Ahmer S. Ail D. Ainsworth M. Aissa M. Aitken L. Ajay B. Ajibode A. Ajmi A. Akhtar N. Akhtar N. Akili S. Akindolie O. Akinfenwa Y. Akinkugbe O. Akinpelu I. Aktinade O. Aaraj A.A.S.A.R. Balushi A.A. Dakhola A.M. Swaifi A.A. Abadi A.E. Aladangady N. Alam A. Alam S. Asadi A.A. Alatzoglou K. Albert P. Albon L. Alcorn G. Alcorn S. Aldana A. Alderdice D. Aldouri R. Aldridge J. Aldridge N. Alegria A. Alexander A. Alexander J. Alexander P.D.G. Fori A.J. Alghazawi L. Hakim A.B. Hity A.S. Ali A. Ali A. Ali F.R. Ali J. Ali M. Ali M. Ali N. Ali O. Ali S. Ali S. Alina A. Aliyuda F. Alizadeh K. Jibury A.M. Juboori A.S. Khalil A.M. Alkhusheh M. Allan F. Allanson A. Allcock R. Allen E. Allen K. Allen L. Allen P. Allen R. Allen S. Allen S. Allen S. Allison K. Allman B. Allsop L. Moasseb A.H. Obaidi A.M. Alomari L. Rabahi A.A. Ramadhani A.B. Saadi A.Z. Alshaer I. Shahi Salman A.R. Shamkhani A.W. Sheklly A.B. Altaf S. Alvarez M. Alzetani M. Amamou S. Amar N. Ambalavanan S. Ambrogetti R. Ambrose C. Ameen A. Amezaga M.R. Amin A. Amin A. Amin K. Amin S. Amin T. Amjad A. Amjad N. Amosun V. Amsha K. Amy P. Anand A. Anandappa S. Anderson J. Anderson L. Anderson M. Anderson N. Anderson R. Anderson R. Anderson W. Andreou P. Andrews A. Andrews A. Andrews J. Aneke K. Ang A. Ang W.W. Angel T. Angela A. Angelini P. Anguvaa L. Anichtchik O. Somuah A.M. Aniruddhan K. Annett J. Anning L. Anstey P.J. Anstey R. Anthony A. Pillai A.A. Antill P. Antonina Z. Anu V. Anwar M. Apostolopoulos A. Appleby S. Appleyard D. Aquino M.F. Araba B. Aransiola S. Araujo M. Archer A. Archer D. Archer S. Ardley C. Arias A-M. Arimoto R. Arkley C. Armah C. Armata I. Armitage A. Armstrong C. Armstrong M. Armstrong S. Armtrong P. Arndt H. Newgass A.C. Arnold D. Arnold R. Arora D. Arora K. Arora P. Arora R. Arter A. Arya A. Arya R. Asandei D. Asghar A. Raby A.C. Ashby H. Ashcroft J. Ashcroft J. Ashcroft S. Asher G. Ashfaq A. Ashish A. Flavell A.S. Ashok S. Ashour A-E-A. Ashraf M.Z. Ashraf S. Ashraq M.B. Ashton D. Ashton S. Ashworth A. Ashworth R. Aslam A. Asogan H. Asrar A. Assaf O. Chamberlain A.R. Athorne D. Atkins B. Atkins C. Atkins S. Atkinson J. Atkinson V. Atraskiewicz B. Attia A.A. Aubrey P. Aujayeb A. Aung A.C.T. Aung H. Aung K.T. Aung Y. Aung Z.M. Austin E. Austin K. Auwal A. Avery M. Aveyard N. Avis J. Aviss G. Avram C. Avram P. Awadzi G. Awan A. Aya A. Ayaz E. Ayers A. Azam J. Azharuddin M. Aziz G. Aziz N. Azkoul A. Shah A.A. Azzopardi G. Azzoug H. Babatunde F. Babi M. Babiker B. Babington G. Babirecki M. Babores M. Osibodu B.A.O. Bacciarelli S. Bachar R. Bacon G. Bacon J. Badal B. Badhan G.R. Badhrinarayanan S. Bae J.P. Baggaley A. Baggott A. Bagley G. Bagmane D. Bagshaw L. Bahadori K. Bailey J. Bailey K. Bailey L. Bailey L. Bailey M. Bailey P. Bailey S. Baillie H. Baillie J.K. Bain J. Bains V. Baird D. Baird K. Baird S. Baird T. Baird Y. Bajandouh A. Baker E. Baker J. Baker J. Baker K. Baker R. Baker T-A. Baker V. Bakere H. Bakerly N. Moffatt B.M. Bakhtiar N. Bakoulas P. Balachandran N. Balan A. Balaskas T. Balasubramaniam M. Balcombe A. Baldwin A. Baldwin A. Baldwin C. Baldwin D. Jones B.R. Balfour J. Ball M. Ballard K. Balluz I. Balmforth C. Balogh E. Baluwala A. Bambridge G. Bamford A. Bamford A. Bamford P. Bamgboye A. Bancroft E. Bancroft H. Banda J. Bandaru K. Bandi S. Bandla N. Bandyopadhyam S. Banerjee A. Banerjee R. Banks H. Banks L. Banks P. Bannister O. Banton L. Bao T. Baptist M. Baqai T. Baral A.M. Baramova D. Barber R. Barbon E. Barbosa M. Barbosa M. Barbour J. Barclay A. Barclay C. Bardsley G. Bareford S. Bari S. Barimbing M. Barker A. Barker D. Barker H. Barker J. Barker L. Barker O. Williams B.K. Barkha S. Barla J. Barlow G. Barlow R. Barlow V. Barnacle J. Barnard A. Barnes D. Barnes N. Barnes T. Barnetson C. Barnett A. Vanes V.A. Barnsley W. Barr A. Barr D. Barratt S. Barrera M. Barrett A. Barrett F. Barrett J. Bartholomew J. Bartlett C. Bartlett G. Barton G. Barton J. Barton L. Barton R. Baruah R. Baryschpolec S. Bashyal A. Basker B. Basnyat B. Basoglu A. Bassett J. Bassett G. Bassford C. Bassoy B. Bastion V. Bastola A. Basumatary A. Bate T. Bateman H.J. Bateman K. Bateman V. Bates E. Bates H. Bates M. Bates S. Batham S. Batista A. Batla A. Batra D. Batty H. Batty T. Baum M. Baumber R. Bautista C. Bawa F. Bawani F.S. Bax S. Baxter M. Baxter N. Baxter Z. Bayes H. Bazari F. Bazaz R. Bazli A. Beacham L. Beadles W. Beak P. Beale A. Bearpark J. Beaumont K. Jewell B.D. Beaver T. Beavis S. Beazley C. Beck S. Beckett V. Beckitt R. Beddall H. Beddows S. Beeby D. Beech G. Beecroft M. Beer S. Beety J. Bega G. Begg A. Begg S. Beghini S. Begum A. Begum S. Begum S. Behan T. Behrouzi R. Beishon J. Beith C. Belcher J. Belfield H. Belfield K. Belgaumkar A. Bell D. Bell G. Bell G. Bell L. Bell L. Bell N. Bell P. Bell S. Bell J.L. Bellamu J. Bellamy M. Bellini A. Bellis A. Bellis F. Bendall L. Benesh N. Benetti N. Benham L. Horner B.G. Bennett A. Bennett C. Bennett G. Bennett K. Bennett L. Bennett S. Bennion K. Benson V. Bentley A. Bentley J. Benton I. Beranova E. Beresford M. Bergin C. Bergstrom M. Bernatoniene J. Berriman T. Berry Z. Best K. Bester A-M. Beuvink Y. Bevan E. Bevins S. Bewick T. Bexley A. Beyatli S. Beynon F. Bhadi A. Bhagani S. Bhakta S. Bhalla R. Bhandal K. Bhandal K. Bhandari A. Bhandari S. Bhanot A. Bhanot R. Bhat P. Bhatnagar R. Bhatt K. Bhayani J. Bhojwani D. Bhuiyan S. Bibby A. Bibi F. Bibi N. Bibi S. Bicanic T. Bidgood S. Bigg J. Biggs S. Biju A. Bikov A. Billingham S. Billings J. Binns A. BinRofaie M. Bintcliffe O. Birch C. Birch J. Birchall K. Bird S. Bird S. Birt M. Bishop K. Bishop L. Bishop L. Bisnauthsing K. Biswas N. Biuk S. Blachford K. Black E. Black H. Black K. Black M. Black P. Blackgrove H. Blackledge B. Blackler J. Blackley S. Blackman H. Blackstock C. Blakemore F. Blamey H. Bland A. Blane S. Blankley S. Blaxill P. Blaylock K. Blazeby J. Blencowe N. Bloom B. Bloomfield J. Bloss A. Bloxham H. Blundell L. Blunsum A. Blunt M. Blyth I. Blyth K. Blythe A. Blythe K. Boampoaa M. Bobie B. Bobruk K. Bodalia P.N. Bodasing N. Bodenham T. Boehmer G. Boffito M. Bohmova K. Bohnacker N. Bokhandi S. Bokhar M. Bokhari S. Bokhari S. Bokhari S.O. Boles A. Bond C. Bond H. Bond S. Bond T. Bone A. Boniface G. Bonney L. Boot S. Borbone J. Borman N. Boshir M. Bottrill F. Bough L. Boughton H. Boult Z. Bourke M. Bourke S. Bourne M. Bousfield R. Boustred L. Bowes A. Bowes A. Bowker P. Bowman L. Bowman S. Bowmer R. Bowring A. Bowyer H. Boyd A. Boyd J. Boyd L. Boyle N. Boyle P. Boyle R. Boyles L. Brace L. Bradder J. Bradley C.J. Bradley P. Bradley P. Bradley P. Potts B.J. Bradshaw L. Bradshaw Z. Brady R. Brady S. Braganza D. Branch M. Frisby B.T. Brannigan J. Brattan S. Bray F. Bray N. Brazil M. Brear L. Brear T. Brearey S. Bremner L. Brend M. Bretland G. Brewer C. Bridgwood G. Brigham S. Bright J. Brightling C. Brimfield L. Brinkworth E. Long B.R. Britten V. Broad L. Broad S. Broadhurst R. Broadley A. Broadway M. Brockelsby C. Brocken M. Brockley T. Brodsky M. Brogan F. Brohan L. Brokke F. Brolly J. Bromley D. Ball B.H. Brooker V. Brookes M. Brooking D. Brooks A. Brooks K. Brooks N. Brooks P. Brooks R. Brooks S. Brooks T. Broomhead N. Broughton C. Broughton N. Brouns M. Brown A. Brown A. Brown C. Brown C. Brown E. Brown H. Brown J. Brown L. Brown N. Brown P. Brown R. Brown R. Brown R. Brown S. Brown T. Brown T. Browne B. Browne C. Browne D. Browne M. Brownlee S. Brraka A. Bruce J. Bruce M. Brudlo W. Brunskill N. Brunton A. Brunton M. Bryant M. Buazon A. Buch M.H. Buchan R. Buchanan R. Buche D. Buck A. Buckland M. Buckley L. Buckley P. Buckley S. Buckman C. Bugg G. Bujazia R. Bukhari M. Bukhari S. Bulbulia R. Bull A. Bull D. Bull R. Bull T. Bulteel N. Bumunarachchi K. Tuble B.R. Burchett C. Burda D. Burden C. Burden T.G. Burgess M. Burgess R. Burgess S. Burman A. Burnard S. Burnett C. Burns A. Burns C. Burns J. Burns K. Burrage D. Burrows K. Burston C. Burton B. Burton F. Burton M. Butcher D. Butler A. Butler J. Butler J. Butler J. Butler P. Butler S. Butt A-T. Butt M.M. Butterworth C. Cowin B.N. Buttery R. Buttle T. Button H. Buttress D. Byrne J. Byrne W. Watts B.V. Cabandugama A. Cade R. Cadwgan A. Cahyareny A. Cairney D. Calderwood J. Caldow D. Calisti G. Callaghan D. Callaghan J. Callens C. Callum D. Calver C. Kelly C.M. Camburn T. Cameron D.R. Cameron E. Cameron F. Cameron S. Cameron S. Camm C. Cammack R.F.D. Campbell A. Campbell A. Campbell B. Campbell B. Campbell D. Campbell H. Campbell H. Campbell J. Campbell M. Campbell R. Campbell W. Hewson C.Q. Camsooksai J. Canclini L. Candido S.M. Candlish J. Caneja C. Cann A. Cann J. Cannan R. Cannon E. Cannon M. Cannon P. Cannons V. Cantliff J. Caplin B. Capocci S. Caponi N. Capp A. Capstick T. Cardwell M. Carey R. Carley S. Carlin T. Carmichael S. Carnahan M. Caroline C. Carpenter J. Carr S. Carrasco A. Carrington Z. Carroll A. Carroll P. Carter J. Carter M. Carter P. Carter P. Cartwright D. Cartwright J-A. Carty C. Carungcong J. Casey S. Cassells A. Castiello T. Castle G. Castles B. Caswell M. Catana A.M. Cate H. Cathcart S. Cathie K. Catley C. Catlow L. Caudwell M. Cavazza A. Cave L. Cavinato S. Cawa F. Cawley K. Caws C. Cendl H. Century H. Cernova J. Cesay M. Cetti E. Chabane S. Chablani M. Chabo C. Chadwick D. Chadwick J. Chadwick R. Chakkarapani E. Chakraborty A. Chakraborty M. Chakravorty M. Chalise B. Chalmers J. Chalmers R. Chamberlain G. Chamberlain S. Chambers E. Chambers J. Chambers L. Chambers N. Chan A. Chan C. Chan C. Chan E. Chan K. Chan K. Chan P. Chan R.P-C. Chan X.H.S. Chandler C. Chandler H. Chandler K.J. Chandler S. Chandler Z. Chandra S. Chandran N. Chandrasekaran B. Chang Y. Chaplin J. Chapman G. Chapman J. Chapman K. Chapman L. Chapman L. Chapman P. Chapman T. Chappell L.C. Chappell L. Charalambou A. Charles B. Charlton D. Chatar K. Chatha C. Chaube R. Chaudhary M.Y.N. Chaudhry I. Chaudhuri N. Chaudhury M. Chauhan A. Chauhan R.S. Chavasse N. Chawla V. Cheater L. Cheaveau J. Cheeld C. Cheeseman M. Chen F. Chen H.M. Chen T. Cheng F. Cheng L.Y. Cheng Z. Chenoweth H. Cheong C.H. Cherian S. Cherrie M. Cheshire H. Cheung C.K. Cheung E. Cheung M. Cheyne C. Chhabra S. Chia W.L. Chiang E. Chiapparino A. Chicano R. Chikwanha Z.A. Chilcott S. Chimbo P. Chin K.W. Chin W.J. Chineka R. Chingale A. Chisem H. Chisenga C. Chisnall B. Chiswick C. Chita S. Chitalia N. Chiu M. Chivima B. Chmiel C. Choi S. Choon Kon Yune W. Choudhary V. Choudhury S. Chow B-L. Chowdhury M. Chowdhury S. Christenssen V. Christian P. Christides A. Christie F. Christmas D. Christopherson T. Christy M. Chrysostomou P. Chua Y. Chudgar D. Chudleigh R. Chukkambotla S. Chukwu M.E. Chukwulobelu I. Chung C.Y. Church E. Church S.R. Churchill D. Cianci N. Ciccone N. Cicconi P. Cinardo P. Cipinova Z. Cipriano B. Clamp S. Clapham M. Clare E. Clare S. Clark A. Clark C. Clark D. Clark F. Clark G. Clark J. Clark K. Clark K. Clark L. Clark L. Clark M. Clark P. Clark R. Clark T. Clark Z. Clarke A. Clarke P. Clarke R. Clarke R. Clarke S. Clarke S. Claxton A. Clay K. Clayton E. Clayton O. Smith C.J. Cleaver C. Clemente de la Torre C. Clements J. Clements S. Clemons F. Clifford R. Clifford S. Clive A. Clouston J. Clueit S. Clyne A. Coakley M. Coakley P.G.L. Cobain K. Cochrane A. Cochrane P. Cockerell M. Cockerill H. Cocks S. Codling R. Coe A. Coetzee S. Coey D. Cohen D. Cohen J. Cohen O. Cohen D. Cohn M. Coke L. Coker O. Colbeck N. Colbert R. Cole E. Cole J. Cole J. Coleman G. Coleman M. Coleman T. Coles H. Colin M. Acevedo C.A. Colley J. Collier D. Collier H. Collini P. Collins E. Collins J. Collins J. Collins N. Collins S. Collins V. Collinson A. Collinson B. Collinson J. Collis M. Colmar M. Colton H.E. Colton J. Colville K. Colvin C. Combes E. Comer D. Comerford A. Concannon D. Condliffe R. Connell L. Connell N. Connelly K. Connolly G. Connor E. Conroy A. Conteh V. Convery R. Conway F. Conway G. Conway R. Conyngham J-A. Cook C. Cook E. Cook G. Cook H. Cook J. Cooke D. Cooke G. Cooke K. Cooke T. Cooper A. Cooper C. Cooper D. Cooper H. Cooper J. Cooper L. Cooper N. Cooper R. Cope T. Corbet S. Corbett C. Corcoran J. Cordell C. Cordle J. Corfield A. Corless J. Corlett A. Cornwell J. Cornwell M. Corogeanu D. Corredera M. Corrigan R. Corry P. Corser R. Cosgrove D. Cosier T. Costa P. Coston C. Cotgrove S. Coton Z. Cottam L-J. Cotter R. Cotterill D. Cotton C. Coull A. Coulson J. Counsell D. Counter D. Coupland C. Courtney E. Courtney J. Cousins R. Cowan A. Cowan E. Cowell R. Cowen L. Cowman S. Cowton A. Cox E. Cox G. Cox K. Cox M. Coy K. Bamford C.A. Craig V. Craighead F. Cramp M. Crause J. Crawford A. Crawford E. Crawford I. Crawshaw S. Brown C.B. Creamer A. Cremona J. Cremona S. Cresswell J. Cribb M. Crichton C. Crilly D. Crisp L. Crisp N. Crocombe D. Croft M. Crook D. Crooks J. Crosby H. Cross E. Cross E. Cross S. Cross T. Crothers A. Crotty S. Crouch S. Crow M. Crowder A. Crowley K. Crowley T. Croysdill R. Cruickshank C. Cruickshank C. Cruickshank I. Cruise J. Cruz C. Cervera C.T. Cryans D. Cui G. Cui H. Cullen L. Fosong C.G. Cunliffe V. Cunningham N. Cunningham N. Cupitt J. Curgenven H. Curnow G. Curran D. Curran S. Currie C. Currie J. Currie S. Curtis J. Curtis K. Curtis O. Curtis T. Cuthbertson R. Cutler S. Czekaj M. Czylok P. D’Arcangelo S. Rocha d.J. Dagens A. Daggett H. Daglish J. Dahiya S. Dale A. Dale K. Dale M. Dale S. Dales J. Dalgleish H. Dallow H. Dalton D. Daly Z. Damm E. Danga A. Daniel A. Daniel P. Daniels A. Dann A. Bamfo D.S. Darbyshire A. Darbyshire J. Dargan P. Dark P. Darlington K. Darnell S. Darton T. Darylile G. Das M. Das S. Daschel M. Dasgin J. Datta D. Daunt A. Dave V. Davenport E. Davey M. Davey M. Davey M. David M. Davidson A. Davidson L. Davidson N. Davidson R. Davies A. Davies A. Davies A. Davies A. Davies C. Davies C. Davies D. Davies E. Davies F. Davies H. Davies J. Davies K. Davies K. Davies K. Davies L. Davies M. Davies M. Davies N. Davies O. Davies P. Davies R. Davies R. Davies R. Davies S. Davies S. Davis A. Davis G. Davis I. Davis J-A. Davis K. Davis P. Davison A. Dawe C. Dawe H. Dawkins M. Dawson D. Dawson E. Dawson J. Dawson S. Dawson T. Daxter A. Day A. Day J. Day J.N. D’Costa J. De P. Fonseka d.D. Freitas d.T. Miranda S.D.F. Sausmarez d.E. Silva d.S. Silva d.T. Sousa D.J. Sousa D.P. Souza d.J. Soyza D.A. Vere d.N. Vos d.J. Deacon B. Dealing S. Dean A. Dean J. Dean K. Dean S. Dean T. Deane J. Dear J. Dearden E. Deary A. Deas C. Debbie S. Debreceni G. Deelchand V. Deeley M. Deery J. Defever E. Forno D.M. Rosa D.A. Dell A. Demetriou C. DeMets D. Democratis J. Denham J. Denis E. Denley L. Denmade C. Dent K. Dent M. Denton E. Denwood T. Deole N. Depala D. Depante M. Dermody S. Desai A. Desai A. Desai P. Deshpande S. Deshpande V. Devkota S. Devkota U. Dey P. Dey V. Deylami R. Dhaliwal K. Dhani S. Dhanoa A. Dhar M. Dhasmana D. Dhillon E. Dhillon R. Dhimal M. Dias P. Diaz S. Pratt D.K. Dickerson D. Dicks P. Dickson S. Digby J. Dillane S. Diment S. Dimitri P. Dinh T.H. Dipper A. Dirmantaite L. Ditchfield L. Diver S. Diwakar L. Dixon C. Dixon G. Djeugam B. Dlouhy P. D’Mello A. Dmitri P. Dobbie L. Oroian D.M. Dobson C. Dobson L. Docherty M. Dockrell D. Dodd J. Dodds J. Dodds R. Dodds S. Dogra R. Doherty E. Doherty W. Doi Y. Doig I. Doke E. Dolan D. Dolman M. Dolman R. Donald L. Donaldson C. Donaldson C. Donaldson D. Donaldson G. Donaldson K. Donnachie J. Donnelly E. Donnelly R. Donohoe A. Donohoe G. Donohue B. Donton S. Dooks E. Doran G. Dorey K. Dorgan S. Dosani M. Dosanjh D. Dospinescu P. Douglas K. Douse J. Dowden L. Dower M. Dowling S. Downer N. Downes C. Downes R. Downes T. Downey D. Downey R. Downs L. Dowson S. Dragan C. Dragos C. Drain M. Drake C. Drew V. Drewett O. Driscoll C. Drogan H. Drummond G. Drury K. Druyeh R. Jones D.J. Drysdale S. Thinh D.A. Dube H. Dube J. Duberley S. Leech D.H. Duff N. Duffield E. Duffy H. Dufour L. Duggan A. Dugh P. Duignan J. Dummer S. Duncan A. Duncan C. Duncan F. Duncan G. Dundas S. Dunn A. Dunn C. Dunn D. Dunn L. Dunn P. Dunne C. Dunne K. Dunning F. Dunphy A. Duraiswamy V. Duran B. DuRand I. Duric N. Durie A. Durie E. Durrington H. Duvnjak H. Dwarakanath A. Dwarakanath L. Dwyer E. Dyball C. Dyer K. Dymond H. Dymond T. Eades C. Eagles L. Early J. Earwaker M. Easom N. East C. Easthope A. Easton F. Eatough R. Ebigbola O. Ebner D. Ebon M. Eccles S. Eddings C. Eddleston M. Edgar M. Edgerley K. Edmond N. Edmondson M. Edmunds T. Edwards A. Edwards C. Edwards J. Edwards K. Edwards M. Eedle J. Egginton D. Ehiorobo L. Eisen S. Ekeowa U. Ekoi M. Ekunola A. Behery E.S. Elbeshy M. Bouzidi E.K. Elder J. Din E.M. Eleanor D. Eletu I. Elfar E. Elgamal M.M. Elgohary A. Elia S. Elias J. Elias T. Elkaram N. Elkins A.V. Ellam J. Ellard N. Ellerton L.N. Elliot L. Elliott A. Elliott F. Elliott K. Elliott S. Ellis A. Ellis C. Ellis K. Ellis T-Y. Ellis Y. Elmahdi R. Elmahi E. Elmasry H-M. Elndari N. Elneima O. Elokl M. Elradi A. Elsaadany M. Sayeh E.S. Sbahi E.H. Elsefi T. Shakankery E.K. Taweel E.H. Elyoussfi S. Emberey J. Emberson J.R. Emberton J. Emmanuel J. Emmerson I. Emms M. Emond F. Emonts M. Enachi N. Engden A. English K. Entwistle E. Enyi H. Erotocritou M. Eskander P. Esmail H. Estcourt L. Evans B. Evans C. Evans D. Evans G. Evans G. Evans J. Evans J. Evans L. Evans L. Evans M. Evans M. Evans R. Evans T. Evans T.J. Everden C. Everden S. Evison H. Evison L. Eyre D. Faccenda J. Fahel L. Fahmay Y. Fairbairn S. Fairbairn T. Fairclough A. Fairlie L. Fairweather M. Fajardo A. Falcone N. Falconer E. Fallon J. Fallow A. Faluyi D. Fancois V. Farah Q. Fard N.Z. Fares L. Farg A. Farmer A. Farmer K. Farmery T. Farnworth S. Farook F. Farooq H. Farooq S. Farquhar F. Farrell A. Farrell B. Farthing J. Farzana S. Fasina R. Fatemi A. Fatemi M. Fatimah N. Faulkner M. Faust S.N. Fawke J. Fawohunre S. Fazal A. Fearby S. Feben A. Fedel F. Fedorova D. Fegan C. Felongco M. Felton L. Felton T. Fenlon K. Fenn A. Fenner I. Fenton C. Fenton M. Ferguson C. Ferguson J. Ferguson K. Ferguson K. Ferguson S. Ferguson S. Ferguson V. Fernandes D. Fernandez C. Fernandez E. Fernandez M. Lopez F.S. Fernando C.J. Feroz A. Ferranti P. Ferrari T. Ferrelly E. Ferrera A. Ferriman E. Fethers N. Field B. Field J. Field R. Fielder K. Fieldhouse L. Fielding A. Fielding J. Fielding S. Fikree A. Filson S.A. Finbow S. Finch D. Finch J. Finch L. Fineman N. Finlayson L. Finn A. Finn J. Finney C. Fiouni S. Fiquet J. Fisher J. Fisher N. Fishman D. Fishwick K. Fitzgerald F. Creamer F.C. Flaherty J. Flanagan M. Flanders C. Fleming J. Fleming L. Fleming P. Flesher W. Fletcher A. Fletcher J. Fletcher L. Fletcher S. Fletcher S. Flewitt K. Flood C. Floodgate I. Florence V. Floyd S. Flynn R. Foden C. Fofana A. Fogarty G. Foley C. Foley P. Folkes L. Font D.M. Foo A. Foo J. Foot A. Foot J. Forbes J. Ford J. Foreman J. Fornolles C. Forrest A. Forsey E. Forsey M. Forshall T. Forster E. Forton J. Foster E. Foster J. Foster R.A. Foster T. Foulds A. Foulds I. Fowe F. Fowler E. Fowler R. Fowler S. Fox C. Fox H. Fox J. Fox L. Fox N. Fox O. Fox S. Foxton S-J. Frake R. Francioni A. Francis O. Francis R. Francis S. Francis S. Bacon F.T. Frankland H. Franklin J. Fraser C. Frayling S. Fredlund M. Freeman C. Freeman E. Freeman H. Freeman N. Freer C. French E. Frise M. Fromson R. Frosh A. Frost J. Frost V. Froud O. Frowd R. Fryatt A. Fuller B. Fuller L. Fuller T. Fullerton D. Fung C. Fung G. Funnell S. Furness J. Fyfe A. G N. Gabbitas E. Gabriel C. Gabriel Z. Gachi H. Gahir J. Gajebasia S. Knapik G.K. Gale C. Gale H. Gale R. Gali S. Gallagher B. Gallagher J. Gallagher R. Gallagher W. Galliford J. Galloway C. Galloway C. Galloway E. Galloway J. Galloway J. Gamble L. Gamble L. Gammon B. Ganapathi J. Ganapathy R. Gandhi K. Gandhi S. Ganesh U. Gani A. Garden E-J. Gardener A.D. Gardiner E. Gardiner M. Gardiner P. Gardiner S. Hill G.C. Gardner J. Garfield M. Garg A. Garlick N. Garner J. Garner L. Garner Z. Garr R. Garty F. Gascoyne R. Gashau H. Gatenby A. Gaughan E. Gaurav A. Gavrila M. Gaylard J. Gaywood E. Geddie C. Gedge I. Gee S. Gellamucho M. Gelly K. Gelmon L. Zapata G.S. Genato G. Gent S. Geoghegan N. George S. George T. Georges S. Georgiou D. Gerard P. Gerdes L. Germain L. Gerrish H. Getachew A. Gethin L. Ghanayem H. Gherman A. Ghosh A. Ghosh J. Ghosh S. Giannopoulou S. Gibani M. Gibbison B. Gibbons K. Gibson A. Gibson B. Gibson K. Gibson K. Gibson S. Gilbert C. Gilbert J. Gilbert K. Giles B. Gill M. Gill L. Gillen P. Gillesen A. Gillespie K. Gillham E. Gillian A. Gilliland D. Gillott R. Gilmour D. Gilmour K. Ginting F. Royal G.T. Gipson A. Girling J. Gisby R. Gkioni A. Gkoritsa A. Klotsas G.E. Gladwell A. Glanville J. Glasgow J. Glasgow S. Glass J. Glass L. Glaysher S. Gledhill L. Glennon A. Glover J. Glover K. Bengtsson G.J. Glowski D. Gnanalingam C. Goddard J. Goddard W. Godden E. Godden J. Godson E. Gogoi S. Goh A. Goiriz R. Gokaraju S. Goldacre R. Goldsmith A. Goldsmith P. Gomersall D. Gomez L. Marcos G.R. Gondal A. Gonzalez C. Goodall J. Goodenough B. Goodfellow L. Goodlife J. Goodwin C. Goodwin E. Goodwin J. Goodyear P. Gooentilleke R. Goonasekara M. Gooseman S. Gopal S. Gordon S. Gore R. Gorick H. Gorman C. Gorman C. Gormely S. Gorog D. Gorst M. Gorsuch T. Gosai J. Gosling R. Gosling S. Gosney G. Goss V. Gotham D. Gott N. Goudie E. Gould S. Gourbault L. Govind A. Gowans S. Gowda G. Gowda R. Gower H. Goyal P. Goyal S. Goyal S. Graham C. Graham J. Graham J. Graham L. Graham S. Brown G.M. Grahamslaw J. Grana G. Grandison T. Grandjean L. Grant A. Grant A. Grant D. Grant M. Grant P. Gravell R. Graves J. Gray A. Gray C. Gray G. Gray J. Gray K. Gray N. Gray S. Grayson A. Greaves F. Greaves P. Green A. Green C. Green C.A. Green D. Green F. Green J. Green M. Green N. Green S. Greene D. Greenfield P. Greenhalgh A. Greenwood D. Greer S. Gregory J. Gregory J. Gregory K. Gregory T. Greig J. Greig J. Grenfell R. Grenier T. Grevatt S. Grey G. Gribbin A. Gribble A. Grieg N. Grieve D. Griffin B. Griffin D. Griffin M. Griffith S. Griffiths A. Griffiths D. Griffiths D. Griffiths D. Griffiths I. Griffiths M. Griffiths N. Griffiths O. Griffiths S. Griffiths Y. Grigoriadou S. Grigsby S. Grobovaite E. Grondin C. Groome R. Grosu L. Grounds J. Grout M. Grover H. Grover H. Groves J. Grubb N. Grundy J. Guarino F. Gudur S. Guettari S. Gulati S. Gulia V. Gunasekera P. Gunawardena M. Gunganah K. Gunn J. Gunter E. Gupta A. Gupta A. Gupta R. Gupta R. Gupta R. Gupta T. Gupta V. Wright G.A. Guratsky V. Gureviciute A. Gurram S. Gurung A. Gurung B. Gurung S. Guth H. Gyanwali P. Habibi R. Hack B. Hackney P. Hacon C. Haddad A. Hadfield D. Hadjiandreou M. Hadjisavvas N. Haestier A. Hafiz N. Hafiz-Ur-Rehman R. Hafsa J. Hagan S. Hague J.W. Hague R. Haigh K. Haines C. Hainey S. Hair M. Hairsine B. Hajnik J. Haldeos A. Halder W. Hale J. Halevy C. Halford P. Halford W. Hall A. Hall A. Hall C. Hall E. Hall F. Hall H. Hall J. Hall K. Hallas J. Hallas K. Hallett C. Halls H. Zadeh H.M. Hameed B. Hamers R. Hamid I. Hamie M. Hamilton B. Hamilton F. Hamilton L. Hamilton N. Hamilton S. Hamlin R. Hamlyn E. Hammans B. Hammersley S. Hammerton K. Hammond B. Hammond L. Hammonds F. Hamoodi I. Hampshire K. Hampson J. Hampson L. Hanci O. Hand S. Handford J. Handrean S. Haney S. Hanif S. Hanison E. Hanison E. Hannah J. Hannington A. Hannun M. Hanrath A. Hanson A. Hanson J. Hanson K. Hanson S. Haq M.U. Haqiqi A. Haque M. Harden L. Harding Z. Hardman S. Hardy J. Haresh K. Harford R. Hargadon B. Hargreaves C. Hargreaves J. Harin A. Haris M. Harlock E. Harman P. Harman T. Harmer M. Haroon M.A. Harper C. Harper H. Harper P. Harper R. Harrhy S. Harrington S. Davies H.Y. Harris J. Harris J. Harris J. Harris L. Harris M-C. Harris N. Harris S. Harrison D. Harrison L. Harrison M. Harrison R. Harrison S. Harrison T. Harrison W. Harrod E. Hart C. Hart D. Hartley L. Hartley R. Hartley R. Hartley T. Hartrey W. Hartridge P. Hartshorn S. Harvala H. Harvey A. Harvey A. Harvey M. Harwood C. Harwood H. Haselden B. Hashem K. Hashimm M. Hashimoto T. Hashmi I. Haslam Z. Hassan A. Hassan A. Hassasing S. Hassell J. Hassell P. Hastings A. Hastings B. Hastings J. Hatch S. Hatton J. Williams H.M. Havlik S. Hawcutt D.B. Hawes K. Hawes L. Hawes N. Hawkins A. Hawkins N. Hawley D. Jones H.E. Haworth E. Hay A. Hay C. Hayat A. Hayat J. Hayathu M-R. Hayder A. Hayes A. Hayes J. Hayes K. Hayes M. Hayes F. Hayle P. Haylett C. Hayman A. Hayman M. Haynes M. Haynes R. Hayre R. Haysom S. Hayward J. Haywood P. Hazelton T. Hazenberg P. He Z. Headon E. Heal C. Healy B. Hearn A. Heath A. Heath R. Heaton D. Hebbron K. Hector G. Hedges A. Hedges K. Heeley C. Heeney E. Heire R. Hemingway G. Hemmila U. Hemphill S. Hemsley D. Henderson A. Henderson E. Henderson J. Henderson S. Henry J. Henry K. Henry L. Henry M. Henry N. Henshall D. Herdman G. Grant H.R. Herkes M. Heron E. Herrington W. Heselden E. Heslop P. Hester S. Hetherington E. Hetherington J. Hettiarachchi C. Hettiarachchi P. Hewer H. Hewertson J. Hewetson A. Hewins S. Hewitt C. Hewitt D. Hewitt R. Hewson J. Hey S. Heyderman R.S. Heydtmann M. Heys J. Heywood J. Hibbert M. Hickey J. Hickey N. Hickey P. Hicks A. Hicks B. Hicks J. Hicks S.R. Higbee D. Higgins L. Higham A. Highcock M. Highgate J. Hikmat M. Hill A. Hill H. Hill J. Hill L. Hill P. Hill U. Hilldrith A. Cooper H.C. Hilton Z. Hinch S. Hindle A. Hindmarsh A. Hine P. Hinshaw K. Hird C. Hives J. Ho B. Hoare M. Hobden D. Hobden G. Hobrok M. Hobson S. Hodge S. Hodgen L. Hodgkins H. Hodgkinson S. Hodgson D. Hodgson H. Hodgson L. Hodgson S. Hodkinson G. Hodson K. Hogben M. Hogg L. Hoggett L. Holborow A. Holbrook C. Holden C. Holden M. Holder T. Holdhof N. Holdsworth H. Holland L. Holland N. Hollands M. Holliday E. Holling N. Hollos L. Holloway S. Hollyer M. Holman A. Holmes A. Holmes M. Holmes R. Holmes R. Holroyd K. Holt L. Holt S. Holt S. Holyome A. Home M. Homewood R. Hong K. Hooper C. Hoosdally S. Hope S. Hope S. Hopkins B. Horby P.W. Horler S. Hormis A. Hornan D. Hornby N. Horne Z. Horner R. Horsford L. Horsford M. Horsford M. Horsham V. Horsley A. Horsley A. Horsley E. Horton S. Hosea J. Hoskins T. Hossain M.S. Hossain R. Hough M. Hough S. Houghton C. Houghton K. Houlihan R. Housely K. Houston H. Hovvels R. How L. Howaniec L. Howard L. Howard L. Howard L. Howard S. Howard S. Griffin H.R. Howarth A. Howe S. Howells M. Howie L. Howlett K. Howlett S. Hrycaiczuk J. Htoon N.Z. Htwe S. Hu Y. Huah C.O. Huckle A. Huda S. Hudak A. Hudig L. Hudson H. Hudson O. Hufton A. Huggins C. Hughes A. Hughes E. Hughes G. Hughes H. Hughes L. Hughes R. Hughes R. Hughes S. Hughes S. Hughes V. Hughes W. Huhn L. Hui C. Hulbert R. Hull D. Hull G. Hull R. Hulme A. Hulme P. Hulse W. Hulston G. Hum R. Hume M. Humphrey C. Humphries A. Humphries J. Hunt F. Hunt J. Hunt K. Hunt L. Hunt S. Hunter A. Hunter E. Hunter K. Hunter N. Hunter S. Huntington G. Hurditch E. Hurley C. Hurley K. Husain M.A. Husaini S.Y. Huson C. Hussain A. Hussain I. Hussain I. Hussain M. Hussain M. Hussain R. Hussain S. Hussain S. Hussain Y. Hussam El-Din M. Hussey R. Hussien A.H. Hutchinson A. Hutchinson C. Hutchinson D. Hutchinson E. Hutchinson J. Hutsby C. Hutton P. Huyen T. Hydes D. Wyatt H.J. Hynes N. Hyslop M. Ibraheim M. Ibrahim A. Ibrahim A. Ibrahim A. Ibrahim M. Ibrahim W. Idowu A.I. Idrees M. Idrees N. Iftikhar H. Iftikhar M. Igwe C. Ijaz M. Ikomi A. Iles C. Iliodromiti S. Ilsley M. Ilves L. Gutierrez J.L. Imray C. Imtiaz H. Ingham J. Ingham J. Ingham R. Ingle T. Inglis J. Ingram A. Ingram L. Inns P. Inweregbu K. Ionescu A.A. Ionita A. Iordanov I.P. Ipe A. Iqbal M. Iqbal M. Sait I.F. Ireland J. Irons R. Irshad M. Irshad M.S. Irvine J. Irvine V. Irving R. Ishak M. Isherwood E. Islam A. Islam S. Islim A. Ismail A. Ismail O. Ison C. Israa M. Isralls S. Ivan M. Ivenso C. Ivy A. Iwanikiw S. Ixer K. Iyer M. Iyer M. Jack C. Jackson A. Jackson B. Jackson B. Jackson E. Jackson H. Jackson L. Jackson M. Jackson N. Jackson S. Jacob P. Jacob R. Jacques N. Jafar A. Jafferji D. Jaffery A. Jagadish C. Jagannathan V. Jagpal M. Jaime F.R. Jain N. Jain S. Jain S. Jaiswal S. Jajbhay D. Jaki T. Jallow B. Jaly Y. Jamal S. Jamal Z. Jameel Y. James A. James C. James K. James L. James L. James M. James N. James O. James R. James R. James T. Jameson J. Jamison A. Jane P. Janmohamed A. Japp D. Jardim V. Jardine C. Jarnell E. Jarvie E. Jarvis C. Jarvis R. Jastrzebska P. Javed H. Jawad M. Jawaheer L. Jayachandran A. Jayachandran D. Jayakumar A. Jayaram D. Jayaram R. Jayasekera G. Jayatilleke T. Jayebalan A. Jeddi S. Jeelani M.S. Jeffery K. Jeffrey H. Jeffrey R. Jeffreys N. Jeffs B. Jegede D. Jemima T. Jenkin I. Jenkins A. Jenkins C. Jenkins D. Jenkins E. Jenkins S. Jenkins S. Jenkins S. Jennings J. Jennings L. Jennings V. Jerome E. Jerry D. Dunton J.E. Silva J.J.A. Jetha C. Jethwa K. Jha R. Jhanji S. Jian K. Jiao Z. Jimenez L. Gil J.A. Jith J. Joefield T. Johal N. Johannessen K. Johari A. John A. John A. John N. Johns E. Johns M. Johnson A. Johnson E. Johnson G. Johnson K. Johnson K. Johnson L. Johnson M. Johnson N. Johnson O. Johnston C. Johnston J. Johnston S. Johnston V. Johnstone D. Johnstone E. Johnstone J. Joishy M. Jones A. Jones A. Jones A. Jones B. Jones B. Jones C. Jones C. Jones C. Jones C.E. Jones D. Jones E. Jones G. Jones G. Jones J. Jones J. Jones J. Jones J. Jones K.E. Jones L. Jones L.M. Jones L. Jones M. Jones N. Jones P. Jones R. Jones R.E. Jones S. Jones S. Jones S. Jones S. Jones T. Jones T. Jones T. Jonnalagadda R. Jordache R. Jose S. Joseph A. Joseph P.A. Joseph R. Joseph S. Joshi D. Joshi M. Joshi P. Josiah B. Joyce T. Ju Wen Kwek A. Jude E. Judge P. Juhl J. Jujjavarapu S. Juniper M. Juszczak E. Jyothish D. Dawa K.K. Kacar M. Kadam N. Kakoullis G. Bhushan K.A. Kalayi R.J.K. Periyasami K.R. Kallistrou E. Kalsoom S. Kam E. Kamara J. Kamath A. Kamath P. Kamath R. Kamerkar S.A. Kametas N. Kamfose M. Kane L. Kankam O. Kannan T. Kant A. Kapil V. Kapoor R. Kapoor S. Kar S. Kara J. Kark R. Karkey A. Karunaratne N. Kasianczuk N. Kasipandian V. Kassam R. Kathirgamachelvam J. Katsande V. Kaul K. Kaur D. Kaur D. Kaur J. Kaur J. Kausar Z. Kawser M.A.A. Kay A. Kay S. Kayappurathu J.N. Kaye C. Kazeem A. Kearns R. Kearsley N. Keating J. Keating J. Keating L. Keddie-Gray E. Keegan B. Keenan N. Kefas J. Kegg S. Keith L. Keke U. Kellett J. Kelly A. Kelly D. Kelly D. Kelly D. Kelly E. Kelly L. Kelly M. Kelly M. Kelly R. Kelly S. Kelly S. Kelly-Baxter M. Keltos M. Kemp T. Kendall-Smith A. Kennard S. Kennedy A. Kennedy J. Kennedy-Hay S. Kenny J. Kent M. Keogan L. Keough A. Kerr A. Kerr A. Kerrison C. Kerry A. Kerslake H. Kerslake I. Kerss H. Keshet-Price J. Kestelyn E. Keyte G. Khadar A. Khalid A. Khalid M.U. Khalid S. Khalil A. Khalil A. Khalil S. Khan A. Khan A. Khan A-I. Khan A. Khan A. Khan A. Khan B. Khan F. Khan K. Khan M.A. Khan M. Khan M. Khan M. Khan N. Khan O. Khan R. Khan S. Khan S. Khan S. Khan T. Khan W. Khatana U.F. Khatri J. Khatri J. Khatun H. Khatun T. Kheia M. Khera J. Khin H.H.E. Khoja N. Khokhar K. Khurana C. Kibutu F. Kidd A. Kidd M. Kidney J. Kidney S. Kieffer W. Kilbane J. Kilby C. Kilich E. Killen E. Kilroy S. Kim B. Kim J.W. Kimber S. King A. King B. King J. King J. King K. King R. King S. King V. King-Oakley E. Kingsmore L. Kinney F. Kiran S. Kirk J. Kirk J. Kirkby A. Kirkham E. Kirkman G. Kirwan U. Kitching T. Kitto L. Kittridge L. Klaczek S. Kleemann F. Kmachia S. Knapp C.P. Knibbs L. Knight A. Knight F. Knight M. Knight S. Knight S. Knight T. Knights E. Knights J. Knolle M. Knott C. Knowles C. Knowles K. Knowles L. Knox E. Knox L. Koch O. Kodituwakku R. Koduri G. Koirata A. Kolakaluri E. Kolodziej M. Kolokouri E. Kon S. Konar N. Kononen M. Konstantinidis A. Koo H.F. Koopmans I. Kopyj E. Korcierz L. Korolewicz J. Koshy G. Kosmidis C. Kotecha J. Kothandaraman E. Koukouflis L. Kouranloo K. Kousar R. Kousteni M. Kovac M. Eskenazia K.A. Krasauskas K. Krishnamurthy R. Krishnamurthy V. Krishnan M. Krishnan H. Krizak S. Krupej S. Kubisz-Pudelko A. Kudsk-Iversen S. Kudzinskas A. Kukadiya C. Kulkarni N. Kumar A. Kumar M. Kumar R. Kumar R. Kumar R. Kumar R. Kumar S. Kumar V. Kundu A. Kunst H. Kurani A. Kurdy M. Kurian R. Kurmars V. Kuronen-Stewart C. Kusangaya R.S. Kushakovsky V. Kuverji A. Kyei-Mensah A. Kyere-Diabour T. Kyi M. Kyi N.M. Kyle L. Kyriaki K-T. Labao J. Lacey L. Lack N. Ladlow E. Lafferty H. Laha S. Lahane S. Lai C. Lai J. Laing R. Laing-Faiers I. Laity E. Lakeman N. Lalloo D. Lalloo F. Lam A. Lamb F. Lamb L. Lamb T. Lambert P. Lameirinhas C. Lami M.K.G. Lamikanra A. Lamont H. Lamparski M. Lamrani D. Lanaghan C. Lancona-Malcolm I. Landers G. Landray M.J. Lane M. Lane N. Lang A. Lang S. Langer D. Langley M. Langoya C. Langthorne E. Large T. Lason W. Last A. Latham S. Latham V. Latham-Mollart J. Latheef A. Latt N. Lau D. Lau E. Laurenson M. Law H. Law J. Law P. Law R. Lawrence E. Lawrence N. Lawrie R. Lawson L. Lay M. Laycock C. Layug R. Lazo M. Le V. Lea A. Lea W. Leadbitter I. Leahy T. Lean R. Leandro L. Leaning D. Leason S. Ledingham M.A. Lee E. Lee H. Lee I. Lee J. Lee S. Lee S.H. Lee S. Lee S. Lee S. Lee T. Lee X. Lee R. Lees D. Lees J. Legge H. Leggett J. Leigh-Ellis K. Leitch N. Lekoudis E. Lemessy P. Lemoine N. Leng K. Lennon K. Lennon L. Leonard K. Leong W. Leopold N. Lepiarczyk O. Leslie I. Lester E. Leuschner U. Levell E. Levett C. Lewin A. Lewis A. Lewis D. Lewis D. Lewis J. Lewis J. Lewis K. Lewis K. Lewis L. Lewis M. Lewis R. Lewis R. Lewis-Clarke C. Lewszuk A. Lewthwaite P. Ley S. Liao A. Licence V. Lieberman D. Liebeschuetz S. Lightfoot N. Lillie P. Lim B. Lim C. Lim E.T. Lim I. Lim T. Lim W.S. Lim W. Limb J. Limbu U. Linares C. Linden D. Lindergard G. Lindley K. Lindsay C. Lindsay E. Lindsay M. Lindsay- Clarke H. Ling M. Lingam C. Linkson L. Linney M. Linsell L. Lippold C. Lipscomb G. Lipscomb K. Lipskis L. Lisboa A. Lister E. Little J. Little S. Liu X. Llanera D.K. Llewellyn R. Llewelyn M. Lloyd A. Lloyd A. Lloyd A. Lloyd A. Lloyd O. Lloyd R. Lo S. Loader D. Lock L. Lock S. Lock S. Locke A. Locke J. Locke T. Lockett T. Lodge J. Lofthouse M. Loftus H. Logan M. Logue C.A. Loh S.Y. Lokanathan S. Lomme K. London E. Long G. Long N. Longhurst B. Longshaw M. Lonnen J. Lonsdale C. Looby L. Loosley R. Lopez P. Lopez P. Lord R. Lorimer C. Loro F. Lorusso R. Loveless R. Lovell M. Loverdou A. Low A. Low J.M. Lowe A. Lowe C. Lowe E. Lowe F. Lowe M. Lowsby R. Lowthorpe V. Lubimbi G. Solomon L.A. Lucas G. Lucas J. Lucey A. Lucey O. Luck S. Luintel A. Luke H. Luke J. Lungu N. Lunia A. Lunn M. Luo J. Luximon C.N. Lyell B. Lyka E. Lynas A. Lynch C. Lynch D. Lynch D. Lynch S. Maamari R-G. Mabb H. Mabelin L. Macaro J. Macconaill K. Macdonald C. Macfadyen C. Macfarlane J.G. Macfarlane J. Macfarlane L. MacInnes L. MacIntyre I. MacIntyre J. Mack K. Mackay C. Mackay E. Mackay L. Mackenzie A. Mackenzie M. Ross M.R. Mackey A. Mackie F. Mackie R. Mackinlay C. Mackintosh C. Mackintosh K. MacLeod M.J. Macmahon M. MacNair A. Macphee C. Macpherson I. Macrae C. MacRaild A. Madden A. Madden M. Madeja N. Madhivathanan P. Madhusudhana M. Madu A. Madziva L. Mafham M. Magee N. Magezi F. Maghsoodi N. Magier C. Magriplis M. Mahabir N. Mahadevan-Bava S. Maharajh A. Maharjan K. Mahaveer A. Mahay B. Mahay K. Mahdi H. Mahendiran T. Mahendran S. Maher S. Maheswaran A. Maheswaran S. Maheswaran T. Mahjoob-Afag P. Mahmood A. Mahmood F. Mahmood W. Mahmood Z. Mahmoud H. Mahony E. Mair L. Majekdunmi T. Majid K. Major R. Majumdar J. Majumdar J. Majumder M.K.H. Makin S. Malanca M. Malcolm H. Malein F. Malhan N. Malik A. Malik G. Maljk M. Mallett P. Mallinder P. Mallison G. Mallon L. Malone E. Maloney G. Mamman M. Man I. Man K. Mancinelli R. Mancuso-Marcello M. Manders T. Manderson L. Mandeville J. Manhas R. Maniero C. Manikonda R. Mann B. Manning J. Mannion P. Mansi K. Manso K. Mansour D. Mapfunde I.T. Mappa P. Maraj H. Marchand C. Marcus N. Marecka M. Margabanthu G. Margalef J. Margarit L. Margaritopoulos G. Margarson M. Maria del Rocio F.M. Pfyl M.T. Mariano V. Maric A. Markham G. Marks M. Marks P. Marouzet E. Marriott A. Marriott C. Marriott N. Marsden B. Marsden C. Marsden K. Marsden P. Marsden S. Marsden T. Marsh R. Marshall A. Marshall A. Marshall G. Marshall H. Marshall J. Marshall J. Marshall N. Marshall R. Marshall J. Martin E. Martin H. Martin H. Martin J. Martin K. Martin K. Martin L. Martin M. Martin N. Martin T. Martin W. Martin S. Martindale T. Martineau M. Martinez L. Garrido M.J.C. Martin-Lazaro J. Ferreira M.L. Maruthamuthu V.K. Maryan G. Mary-Genetu R. Maryosh S. Masani V. Maseda D. Mashate S. Mashhoudi Y. Mashta A. Masih I. Masih S. Maskell N. Maskell P. Masoli M. Mason R. Mason R. Mason R. Mason C. Masood M. Masood M.T. Masood S.S.M.E. Masud A. Matapure L. Matei C. Matewe R. Matharu M. Mathen S. Mather A. Mather N. Mathers J. Matheson J. Mathew A. Mathew A. Mathew M. Mathew V. Mathews J. Mathias K. Mathioudakis A. Matila D. Matimba-Mupaya W. Matin N. Matisa E. Matonhodze M. Matovu E. Mattappillil J. Matthews A.J. Matthews H. Matthews H. Maxton F. Maxwell A. Maxwell V. May J. May J. May P. Mayanagao I. Maycock M. Mayers G. Maynard V. Mayor S. Mazen I. Mazzella A. Mburu N. McAleese E. McAlinden P. McAlpine A. McAlpine G. McAndrew J. McAuley H. McAuliffe S. McBrearty C. McBride E. McBuigan M. McBurney J. McCabe L. McCairn A. McCammon J. McCammon N. McCann C. McCann E. McCarrick A. McCarron B. McCarthy E. McCarthy M. McCarthy N. McCaughey S. McChlery G. McClay T. McClelland B. McClintock D. McCormack P. McCormick J. McCormick W. McCourt P. McCrae J. McCready S. McCreath G. McCreedy H. McCullagh I.J. McCullagh L. McCullagh M. McCullough C. McCullough K. McCullough N. McCullough S. McCurrach F. McDermott P. McDermott R. McDevitt K. McDill H. McDonald B. McDonald C. McDonald D. McDonald R. McDonald S. McDonald D. McDougall R. McEleavy I. McEntee J. McEvoy E. McEwen R. McFadden M. McFarland D. McFarland M. McFarland R. McGarry E. McGarvey L. McGenily L. McGettigan C. McGettrick M. McGhee C. McGill F. McGinnity S. McGivern H. McGlinchey N. McGlone P. McGlynn D. McGoldrick C. McGoldrick C. McGough E. McGrath B. McGregor A. McGregor A. McGuinness H. McGuire S. McHugh T. McInnes C. McInnes N. McIntyre K. McIntyre M. McKay L. McKeag C.P. McKee M. McKeever J. McKenna S. McKeogh D. McKerr C. McKie A.M. Mckie L. McKnight G. McLachlan H. McLaren A. McLaren B. McLarty N. McLaughlin M. McLay J. McLeish M. McLennan T. McLure S. McMahon A-M. McMahon G. McMahon M. McMahon S. McManus T. McMaster M. McMaster P. McMeekin S. McMillan N. McMinn J. McMorrow L. McNally H. McNeela F. McNeil L. McNeill C. McNeill S. McNelis U. McNulty M. McNulty R. McParland C. McPhail M. McQueen A. McSkeane A. McSorland D. McTaggart G. McTaggart J. Mead J. Meadows E. Meakin O. Mearns B. Mearns C. Mears K. Mears W. Meda M. Mediana A. Medine R. Medveczky T. Meehan S. Meeks E. Megan A. Meghani N. Meghjee S. Mehar A. Mehra R. Meiring J. Mejri R. Melander S. Melinte A-S. Mellor F. Mellor S. Mellor Z. Mellows K. Melnic V. Melville A. Melville J. Membrey H. Mencias M. Mendonca C. Mentzer A. Menzies D. Mepham S. Mercer O. Mercer P. Merchant A. Merchant F. Mercioniu M. Meredith M. Morillas M.M. Merrick B. Merritt J. Merritt S. Merwaha E. Message S. Metcalf-Cuenca G. Metcalfe B. Metcalfe K. Metherell S. Metryka A. Mew L. Meyrick S. Mguni N. Miah A. Miah J. Miah N. Mic G. Micallef D. Michael A. Michael A. Michael S. Michalak N. Michalca-Mason L. Middle J. Middleton H. Middleton J.T. Middleton M. Middleton S. Mieres S. Mihalca-Mason L. Mikolasch T. Milgate S. Millar C. Millar J. Millard J. Miller D. Miller J. Miller L. Miller R. Miller-Biot N. Miller-Fik A. Millett L. Milligan H. Milligan I. Milliken C. Millington K. Millington S. Mills H. Mills J. Millward H. Millward S. Miln R. Milne A. Milne C. Milne L. Milner J. Min Z. Mindel S. Minnis C. Minnis P. Minton J. Miranda F. Mirza T. Misbahuddin A. Mishra A. Mishra B. Mishra E. Mishra R. Misra S. Mistry D. Mistry H. Mital D. Mitchard S. Mitchell B. Mitchell P. Mitchelmore P. Mitra A. Mitra A. Mitra S. Moakes E. Moatt E. Modgil G. Mohamed A. Mohamed A. Mohamed O. Mohammad W. Mohammed A. Mohammed O. Mohammed Y.N.S. Mohamud B.A. Moharram A. Mok H-P. Mok J. Moller-Christensen C. Mollet M. Molloholli M. Molloy A. Molloy L. Molyneux A. Momoniat T. Monaghan H. Monaghan K. Mongolu S. Monika T. Monsell K. Montasser M. Montgomery A. Montgomery H. Moodley P. Moody M. Moody N. Moon A. Moon J. Moon J-H. Moon M. Moonan M. Moondi P. Moore A. Moore C. Moore D.A.J. Moore F. Moore J. Moore L. Moore S. Moore S. Moores R. Morab E. Morales J. Moramorell N. Moran L. Moray G. Moreno-Cuesta J. Morgan A. Morgan C. Morgan C. Morgan C. Morgan L. Morgan L. Morgan M. Morgan P. Morgan-Jones K. Morgan-Smith E. Morley A. Morley T. Morley W. Morris A. Morris D. Morris F. Morris H. Morris J. Morris K. Morris L. Morris L. Morris M-A. Morris N. Morris P. Morris S. Morris S. Morrison D. Morrison M. Morrison S. Morrissey M. Morrow A. Morselli F. Mortem G. Mortland V. Morton C. Morton G. Morzaria P. Moss A. Moss C. Moss S. Moss S. Motherwell N. Mouland J. Moulds C. Moulton H. Mousley E. Moxham K. Moya B. Moyo Q. Mshengu E. Mtuwa S. Muazzam A. Muazzam I.A. Muchenje N. Mudawi D. Muddegowda G. Mugal I. Mughal A. Muglu J. Muhammad J. Muir C. Mukherjee D. Mukhtar S.A.A. Mukimbiri D. Mulgrew P. Mulhearn B. Mulla A. Mullan D. Kutten M.D. Mullen N. Mullett R. Mulligan S. Mumelj L. Mumford A. Munavvar M. Munby H. Munro A-M. Munt S. Mupudzi M.D. Murad A. Muraina O.H. Muralidhara K. Murdoch M. Murira J. Murphy A. Murphy C. Murphy G. Murphy P. Murphy S. Murphy S. Murray C. Murray D. Murray E. Murray K. Murray K. Murray L. Murray L. Murray T. Murtagh E. Murthy M. Murton C. Murton R. Muru N. Musanhu R. Mushabe M. Mushtaq O. Mustafa A.M.M. Mustafa E. Mustafa M. Mustapha I. Mustufvi Z. Mutch C. Mutema E. Muthukrishnan B. Mutton S. Muzengi N. Mwadeyi M. Mwale B. Mwaura E. Myagerimath R. Myers A. Myers S. Myint K.S. Myint Y. Myslivecek L. Nadar E. Nadeem I. Nadheem M. Naeem A. Naeem H. Naeem S. Nafees S. Nafei M. Nagarajan T. Nagra I. Nagra D. Naguib M. Naguleswaran K. Nagumantry K.S. Naicker K. Naidoo S. Naik G. Naik R. Naik S. Nair D.S. Nair R. Nair T. Naisbitt J. Naismith K. Nallapareddy S. Nallapeta S. Nallasivan A. Nanda U. Nandani A. Naqvi A.R. Naqvi A. Naqvi S. Nasa S. Nash D. Nasheed N. Nasimudeen A. Nasir U. Nasser T. Natarajan A. Natarajan G. Natarajan N. Natarajan N. Natarajan R. Nathaniel N. Nathvani M. Nathwani P. Nava G. Navaneetham N. Navaratnam J. Navarra H. Naveed S. Navin J. Nawaz K. Nawaz S. Nawaz S. Nayar B. Naylor S. Nayyar M. Naz F. Naz M. Nazari B. Nazir S. Nazir S. Ncomanzi D. Ndefo O. Neal A. Neary E. Negmeldin M. Neill P. Neils H.E. Nejad A. Nel L. Nelson M. Nelson R. Nelson S. Nelwan E. Nemane R. Nepal S. Nethercott D. Netherton K. Nettleton K. Newby A. Newby A. Newby D. Newcombe T. Newman D. Newman J. Newman O. Newman T. Newman T. Newport R. Newton M. Ng A.Y.K.C. Ng K.W. Ng M. Ng S. Ng W.J. Ngan T. Ngui G.C.E. Ngumo A. Fhogartaigh N.C. Nicholas N. Nicholas P. Nicholls D. Nicholls L. Nicholson A. Nicholson A. Nicholson A. Nickson I. Nicol E. Nicol E. Nicol R. Nicola P. Nicoll A. Nikolaos P. Nikonovich G. Nilsson A. Nimako K. Nimako L. Nimmo C. Ninan P. Nirmalan M. Nisar M. Nisbett T. James N.A. Nishat S. Nishiyama T. Nix S. Nixon J. Nixon M. Nizam Ud Din K. Nizami M. Noba L. Noble H. Noe H.M. Nolan J. Noor Z. Noori Z. Norman L. Norman R. Norris K. Norris L. Nortcliffe S.A. North F. North J. North T. Northfield J. Northover S. Nortje J. Norton D. Norton R. Notman H. Nourein K. Novak T. Nugdallah M. Nugent A.M. Nugent J. Nundlall K. Nune A. Nunn K. Nunn M. Nunnick J. Nupa Y. Nurgat Z. Nyamugunduru G. Nyirenda M. Nyland K. Shea O.D. O’Hara C. O’Reilly K. O’Rourke W. Oakley C. Obale B. Oboh C. O’Brien C. O’Brien J. O’Brien K. O’Brien L. O’Brien N. O’Brien R. O’Brien T. O’Bryan E. Obukofe R. O’Callaghan C. O’Connell L. OConnor T. O’Connor C. O’Connor G. Odam M. Oddie S. Oddy S. Odedina Y. Odedra K. Odelberg S.W. Odell N. Oderinde O. Odone J. O’Donovan C. O’Farrell S. Offord P. Ogbara T. Ogilvie C. O’Gorman C. Ogunkeye O. Ohia U. Ohja S. Ojo O. O’Kane M. Okeke T. OKell E. Okines A. Okpala I. Okpo E. Okpoko F. Okubanjo M. Olaiya R. Old T. Oleszkiewicz G. Oliveira M. Oliver A. Oliver C. Oliver J. Oliver M. Oliver Z. Olokoto N.O. Olonipile F. Olufuwa O. Olukoya O. Oluwole-Ojo A. O’Malley L. Omar M. Omar Z. Omer N. O’Neill C. O’Neill L. Ong C.S. Onyeagor C. Ooi H.C. Oomatia A. Opena M. Oram R. Ord C. Ord J. Orekoya L. O’Riordan D. O’Riordan S. Orme A. Orme H. Orr C. Orr S. Orton C. Osadcow A. Osagie R. Osanlou R. Osborne L. Osborne N. Osborne R. Osborne W. Osborne W. Osbourne C. Osei-Bobie J. Osman J. Osman W. Osman B. Osoata G. Ostermann M. O’Sullivan E. O’Sullivan S. Otey N. Otite O.K. O’Toole M. Otter A.D. Owen R. Owen S. Owens E. Owoseni Y. Owston M. Oxlade R. Ozdes F. Pack J. Packham S. Paczko P. Padden G. Padmakumar A. Page I. Page J. Page V. Paget J. Pagett K. Paisley L. Pajak S. Pakozdi A. Pal S. Pal S. Palacios A. Sai P.V.B. Palaniappan V. Palanivelu P. Palfreeman A. Palit D. Palmer A. Palmer L. Pamphlett I. Pan D. Pandey A. Pandian N. Pandya K. Pandya T. Panes A. Pang Y.W. Pannell L. Pannu K. Pant S. Panthakalam S. Pantin C.T. Pao N. Papaconstantinou H. Papineni P. Paques K. Paradowski K. Parambil V. Paranamana S. Parashar S.R. Parberry I. Parekh A. Parekh D. Parfitt L. Parfrey H. Parikh O. Parish G. Park J. Parker A. Parker B. Parker E. Parker J. Parker J. Parker L. Parker L. Parker S. Parker S. Parkin K. Parkinson A. Parkinson V. Parmar C. Parmar V. Parris V. Parry H.C. Parslow-Williams S. Parsonage M. Parsons P. Partridge R. Parvin K. Passby L. Passey S. Pastrana J. Patal M. Patch S. Patel A. Patel A. Patel A. Patel D. Patel D. Patel H. Patel J. Patel K. Patel K. Patel K. Patel K. Patel M. Patel M. Patel M. Patel N. Patel N. Patel P. Patel S. Patel S. Patel T. Patel V. Pathak S. Pathan N. Patience A. Patience D. Patrick A. Patrick G. Patrick J. Patten S. Pattenden B. Patterson C. Patterson L. Patterson M. Patterson R. Paul S. Pauls L. Paulus S. Pavely A. Pavord S. Payne B. Payne E. Payne R. Peacock L. Peacock L. Peacock S. Peake H. Pearce J. Pearse R. Pearson A. Pearson D. Pearson H. Pearson K. Pearson S.A. Pearson S. Peasley A. Peddie H. Peek R. Pegg C. Peglar S. Peirce B.H. Pelham C. Pemberton A. Penacerrada M. Pender A. Pendlebury C. Pendlebury J. Penfold R. Penman C. Penman J. Penman R. Penner J. Penney K. Penny J. Pepperell J. Pereira A. Pereira R. Pereira Dias Alves C. Perez E. Perez J. Perinpanathan T. Periyasamy L. Perritt E. Perry A. Perry E. Perry M. Perumpral T.M. Pessoa-Amorim G. Petch R. Peter L. Peters C. Peters M. Peters S. Peters T. Petersen R. Peterson A. Peto L. Petras I. Petrova B. Petrova M. Pfeffer P. Phanish M. Phelan P. Philbey C. Philbin J. Phillips A. Phillips D. Phillips R. Phipps M. Phongsathorn V. Phull M. Pick S. Pickard J. Pickering C. Pickering G. Pickett T. Pickford H. Pickles J. Pickwell-Smith B. Pieniazek N. Piercy C. Pieris A. Pilgrim S. Pillai P.A. Pilsworth Z. Pinches H. Pinches S. Pine K. Pinjala M.T. Pintus S. Piper G. Pirani T. Pittman M. Pitts S. Plaatjies N. Platt N. Pleass R. Ploeg R. Plummer L. Plumptre C. Pobjoy J. Pogreban T. Poku S. Pollard R. Pollock L. Poluyi O. Polwarth G.J. Pomery F. Ponnusamy P. Ponnusamy S. Ponnuswamy A. Ponte Bettencourt dos Reis I. Pooboni S. Poole A. Poole L. Poole M. Poon S. Poonian T. Porter D. Porter J. Porter L. Porter R. Postlethwaite K. Pothina N. Potla P. Potoczna D. Pott J. Potter A. Potter J. Potter S. Potter T. Potton E. Potts J.B. Potts J. Potts K. Poudyal B. Poultney U. Poulton K. Poustie V. Powell J. Powell J. Power D. Power N. Powter G. Poxon J. Poyner R. Pradhan V. Prady H. Prasad A. Prasad K. Raj P.F. Prasath S. Pratheepkumar S. Pratley A. Pratt S. Preiss D. Prendergast C. Prentice L. Prentice P. Prescott V. Presland L. Prest C. Preston S. Pretorius M. Prevatt N. Prew S. Price A. Price C. Price C. Price D. Price E. Price N. Price V. Priest A. Prieto J. Primrose L. Prince C. Prince J. Prince L. Pringle S. Pristopan V. Pritchard K. Pritchard L. Pritchard S. Priyash V. Procter A. Proctor C. Proudfoot R. Prudon B. Pryor D. Pudi S. Pugh J. Pugh L. Pugh M.T. Pugh N. Pugh R. Puisa V. Punia K. Abdulsamad P.S. Purandare L. Purchase D. Purdue C. Purewal B. Pursell M. Purssord G. Purves R. Purvis S. Puspatriani K. Puxty K. Puyrigaud Z. Pynn M. Qadeer T. Qayum M. Quah C. Quaid S. Quail N. Quamina C. Quayle A. Quek E. Quenby S. Qui X. Quick V. Quigley J. Quijano-Campos J-C. Quinn A. Quinn J. Quinn T. Quratulain Q. Qureshi D. Qureshi E. Qureshi H. Qureshi K. Qureshi N. Qurratulain Q. Qutab S. Rabbani M.S. Rabinowicz S. Raceala M. Rachman R. Rad L. Radford J. Radford L. Radhakrishnan J. Rafique C. Rafique J. Rafique M. Ragatha R. Raghunathan A. Raguro A. Raha S.D. Rahama S. Rahardjani M. Rahilly K. Rahim F. Rahimi A.H. Rahimi H.R. Rahman M. Rahman S.U. Rai P. Raisova L. Raj A. Rajagopalan P. Rajaiah N. Rajalingam K. Rajasekaran A. Rajasri A. Rajbhandari S. Rajeswaran T. Rajeswary J. Rajkanna J. Rajmohan G. Rallan R. Ralston K. Ralston M. Ram M. Ramabhadran B. Ramali F. Ramali M. Ramanan A. Ramanna S. Ramasamy M. Rambe I. Ramdin D. Ramirez J. Ramirez M. Ramnarain G. Ramos L. Rampling T. Ramraj S. Ramshaw A. Rana A. Rana G.F. Rana R. Rand A. Rand J. Randheva H. Ranga P. Rangar M. Rangarajan H. Ranjan S. Rank H. Ranka P. Rankhelawon R. Rao A. Rao S. Rao S. Rao D. Rasheed A.A. Rashid K. Ratcliff S. Ratcliffe S. Ratcliffe S. Rath S. Rather M.I. Rathore S. Ratnakumar A. Ratoff J. Rattehalli D. Raw J. Raw R. Rawlins H. Ray G. Raymond-White A. Raynard D. Rayner N. Raynsford A. Razvi S. Razvi Z. Read K. Read S. Reddy A. Reddy A. Reddy H. Redfern-Walsh A. Redome A. Redome J. Reed A. Reed J. Rees A. Rees J. Rees M. Rees S. Rees S. Rees T. Regan F. Regan K. Regan S. Rege K. Rehan A. Rehman A. Rehman S. Rehman Z. Reid A. Reid A. Reid J. Reid J. Reid S. Reilly M. Reith C. Remegoso A. Rengan D. Renshaw S. Vattekkat R.R. Reschreiter H. Revels M. Rewitzky G. Rey S. Reynard C. Reynish D. Reynolds P. Reynolds P. Rhodes J. Riaz N. Rice E. Rice M. Rich M. Richards A. Richards A. Richards L. Richards S. Richardson C. Richardson J. Richardson N. Richardson N. Riches J. Riches K. Richmond L. Richmond R. Ricketts W. Rickman H. Riddell A. Ridha M. Ridley C. Ridley P. Rieck G. Rigby L. Rijal S. Riley H. Riley M. Riley P. Rimainar A. Rimba Z.V.P. Rimmer D. Rintoul R. Riordan A. Ripley D. Rippon N. Rishton C. Riste M. Ritchie D. Ritchie J. Ritchings A. Ortega R.P. Rivers V. Rizvi B. Rizvi S.A.S. Rizvi S.H.M. Robb J. Roberts D.J. Roberts I. Roberts J. Roberts J. Roberts K. Roberts M. Roberts N. Roberts P. Roberts R. Robertson C. Robertson J. Robertson J. Robertson N. Robertson S. Robin N. Robinson C. Robinson E. Robinson G. Robinson H. Robinson J. Robinson K. Robinson M. Robinson R. Robinson S. Robinson A. Robson S. Roche L. Roche S. Rodden N. Roddick A. Roddy J. Roderick M. Rodger A. Rodger F. Rodger M. Rodgers A. Rodgers D. Rodgers N. Rodgers P. Rodriguez-Belmonte R. Roe N. Roehr C. Rogers G. Rogers J. Rogers J. Rogers J. Rogers L. Rogers L. Rogers M. Rogers P. Rogers S. Rogers T. Rogers P. Rokadiya S. Rollins L. Rollo J. Rolls C. Roman A. Rook C. Rooney K. Rooney L. Rosaroso L.P. Rose A. Rose A. Rose S. Rose Z. Rosier J. Ross J. Rossdale J. Rothman A. Rothwell J. Roughley L. Rowan K. Rowan N. Rowan S. Rowe A. Rowe C. Rowe-Leete L. Rowlands B. Rowley M. Roy S. Royds M. Roynon-Reed A. Rozewicz S. Rudenko A. Rudrakumar S. Rudran B. Ruff S. Rughani P. Rundell S. Rushmer J. Rusk D. Russell P. Russell R. Russo C. Rutgers M. Ryan A. Ryan B. Ryan K. Ryan L. Ryan M. Ryan P. Ryan P. Ryan-Wakeling D. Saad M. Sabale J. Sabaretnam S. Sadiq N. Sadler E. Saffy A. Sage B. Sagoo H. Sagrir S. Saha R. Saha S. Sahdev N. Sahedra S. Sahota J. Said N. Sakthi S. Sakuri H. Saladi M. Salam A. Salberg A. Salciute E. Saleeb G. Saleh M. Salih H. Salih L. Salisbury S. Saliu S.E. Salman R. Salmon J. Salutous D. Sam M. Sam S. Samakomva T. Saman R. Samar S. Samlal R. Sammons E. Sammut D. Sammut M. Sampath S. Sampson C. Sampson J. Samson A. Samson A. Samuel J. Samuel M. Samuel R. Samuel T.D.L. Samuel Y. Samuels T. Samways J. Samyraju M. Sana I. Sanchez V. Gonzalez S.A. Sanda-Gomez A. Sandercock P. Sanderson A. Sanderson T. Sandhi P. Sandhu K. Sandhu L. Sandow S. Sandrey V. Sands S. Sangombe M. Sanju M. Sankaran L. Santos F. Santosh R. Sanyal J. Sanz-Cepero A.F. Saragih D. Saralaya D. Saraswatula A. Sarella J. Sarfatti A. Sargent R. Sari B. Sari D. Sarkar K. Sarkar R. Sarma S. Sarwar Z. Sass T. Sathe S. Sathianandan S. Sathyanarayanan A. Sathyanarayanan L.S.J.P. Sathyapalan T. Satodia P. Saulite V. Saunders A. Saunders R. Saunders S. Saunderson A. Savill H. Savlani K. Saxena G. Saxton M. Sayan A. Scaletta D. Scanlon D. Scanlon J. Scarratt L. Scattergood S. Schadenberg A. Schafers J. Schneblen W. Schofield R. Schofield S. Scholes D. Scholes K. Schoolmeesters A. Schumacher N. Schunke N. Bruce S.M. Schwarz K. Scobie A. Scorrer T. Scott A. Scott A. Scott A. Scott C. Scott C. Scott E. Scott K. Scott L. Scott M. Scott S. Scott T. Scourfield S. Scrase W. Scullion A. Scullion T. Seager E. Seagrave C. Seaman R. Sear E. Seaton I. Seckington A. Sedano J. Seddon G. See Y.Y. Seelarbokus M.A. Sefton C. Segovia M. Seidu F. Sekadde G. Selby F. Selby G. Sellar C. Sellers K. Selley J. Sellick V. Selman H. Selvadurai G. Selvarajah B. Selvaskandan H. Selvendran S.S. Selwyn J. Semple G. Sen N. Sen S. Sengupta A. Sengupta N. Senra S. Senya H.J. Setty N. Seward A. Sewdin T. Seymour J. Shabbir H. Shackley F. Shafi T. Shah A. Shah A. Shah A. Shah B. Shah M. Shah N. Shah P. Shah P. Shah Q. Shah S.H. Shah S. Shah S. Shah S. Shah W. Shahad S. Shahi S. Shahnazari S. Shahzeb M. Shaibu A. Shaida Z. Shaikh A.Y. Shaikh M. Shail R. Shaji M. Shakeel M. Shalan K. Shamim N. Shams K. Shanahan T. Sharaf H. Sharif A. Sharma A. Sharma A. Sharma B. Sharma M. Sharma O. Sharma P. Sharma R. Sharma S. Sharma S. Sharma S. Sharma S. Sharp A. Sharp C. Sharp G. Sharratt P. Sharratt P. Sharrocks K. Shashaa S. Shaw C. Shaw D. Shaw D. Shaw D. Shaw J. Shaw J. Shaw L. Shaw T.G. Shawcross A. Shawe J. Shayler L. Shedwell S. Sheffield J. Shehata Z. Sheik A. Sheikh A. Sheikh N. Shelley B. Shelton S. Shenoy A. Shenton J. Shepherd A. Shepherd K. Shepherd L. Shepherd S. Sheppeard R. Sheridan H. Sheridan R. Sherridan S. Sherris L. Sherwin S. Shibly S. Shioi C. Shirgaonkar A. Shirley K. Shonubi A. Shortman R. Shotton R. Shotton S. Shpuza E. Shrestha A. Shrestha A. Shrestha N. Shrestha S. Shuker K. Shurmer J. Siame G. Siamia L. Siddavaram S. Siddique N. Siddique S. Sikondari N. Moniz S.C. Sim M. Simangan T. Simbi V. Sime R. Simmons O. Simms R. Simon M. Simon N. Simpson A. Simpson A. Simpson D. Simpson G. Simpson J. Simpson K. Simpson P. Simpson T. Simpson K. Sing C. Singh A. Singh C. Singh J. Singh J. Singh L. Singh M. Singh N. Singh P. Singh P. Singh S. Singh S. Singhal P. Singizi B. Sinha M. Sinha U. Sisson G. Sithiravel S. Sivakumar K. Sivakumar S. Sivakumran D. Sivanadarajah S. Sivasothy P-R. Skehan N. Skelly R. Skelton O. Skene I. Skinner D. Skinner T. Skinner V. Skorko A. Skorupinska I. Skorupinska M. Slack A. Slack K. Slack W. Slade H. Slade M. Slater L. Slawson N. Sloan A. Sloan B. Sloan D. Sloane G. Small B. Small E. Small S. Smalls D. Smallshaw K.D. Smallwood A. Smit C. Smith A. Smith A. Smith A. Smith A. Smith A. Smith C. Smith C. Smith C. Smith D. Smith E. Smith H. Smith H. Smith H. Smith J. Smith J. Smith K. Smith K. Smith L. Smith L. Smith L. Smith L. Smith M. Smith M. Smith O. Smith R. Smith R. Smith R. Smith S. Smith S. Smith S. Smith S. Smith S. Smith I. Smith J. Smolen S. Smuts S. Smyth N. Snell A. Snell D. Snell L. So B. Soan M. Sobande T. Diaz S.A. Sohail B. Sohail B. Sohal H. Soiza R. Solademi O. Soleimani B. Solesbury A. Solly R. Solomon L. Somalanka S. Somashekar C. Sonia R. Soo S-C. Soor P. Soothill G. Soren J. Sothinathan A. Sothirajah P. Soussi N. Southam D. Southern D. Southern I. Southern L. Southin S.M. Southwell J. Southworth T. Sowter J. Spalding C. Spata E. Spears K. Spears M. Spence M. Spencer B. Spencer G. Spencer S. Spencer T. Spickett H. Spillane J. Spiller W. Spinks K. Spinks M. Spittle N. Spriggs J. Spring O. Squires G. Squires J. Squires R. Sreenivasan R. Sreenivasan S. Paranthamen S.K. Srinivasan R. Srirajamadhuveeti A. Srirathan V. Stacpoole S. Stadon L. Staines J. Staines N. Stammers K. Stanciu R. Stanczuk G. Staples R. Stapley S. Staplin N. Stark A. Starr M. Stead R. Steele C. Steer J. Stefania V. Stefanowska P. Stemp C. Stephens A. Stephensen D. Stephenson E. Sterrenburg M. Stevens M. Stevens W. Stevenson A. Stevenson A. Stevenson L. Stevenson S. Steward M. Stewart C. Stewart C. Stewart M.K. Stewart R. Stewart R. Stickley J. Stiller G. Stirrup S. Stock S. Stockdale A. Stockham L. Stockton P. Stoddard E. Stokes C. Stone B. Stone R. Stone S. Storey I. Storton K. Stourton F. Strachan A. Strait C. Stratton E. Stratton J. Straw S. Streit D. Stride E. Stringer S. Strong-Sheldrake S. Struik S. Stuart C. Stubbs A. Stubbs H. Sturdy A. Sturney S. Stuttard M. Suarez C. Subba K. Subbe C.P. Subramanian M. Subramanian V. Subudhi C. Suckling R. Sudershan S. Sugden P. Sukla R. Suliman A. Suliman F. Sultan S. Sundar S. Sundhar R. Sung E. Sunni N. Suntharalingam J. Sur A. Suresh D. Suresh S. Surtees M. Susan C. Suter D. Sutherland H. Sutherland R. Sutherland R. Sutinyte D. Sutton D. Sutton S. Sutu M. Svensson M-L. Svirpliene S. Swain A. Swain R. Swaine T. Swales C. Swart T. Sweetman S. Sweity S. Swift E. Swift P. Swift P. Swift R. Swingler R. Swinhoe S. Swist-Szulik K. Swithenbank L. Syed O. Sykes C. Sykes D. Sykes E. Sylvester L. Symon D. Syndercombe A. Syrimi Z. Syson J. Szabo G. Szakmany T. Szekely M. Szeto M. Tadros M. Tageldin A. Tague L. Tahir H. Tahir M. Takyi A. Talbot P. Talbot -Smith A. Talbot-Ponsonby J. Tallent R. Tallon B. Tamblin-Hopper P. Tan A. Tan B.T. Tan H. Tan H. Tan K. Tan W.T. Tana A. Tanney C. Tanqueray T. Tanton E. Tantri A. Tarft H. Tarft H. Taribagil P. Tarin O. Tariq S. Tarpey D. Tarrant L. Tasiou A. Tate M.L. Tatham K. Tavoukjian V. Taylor A. Taylor B. Taylor C. Taylor D. Taylor E. Taylor J. Taylor J. Taylor J. Taylor J. Taylor K. Taylor L. Taylor M. Taylor M. Taylor M. Taylor N. Taylor R. Taylor R. Taylor S. Taylor S. Taylor T. Taylor V. Taylor-Siddons M. Taynton T. Te A. Teasdale J. Tebbutt J. Tee C. Tejwani R. Telfer A. Teli V. Tempany J. Temple J. Temple N. Tench H. Teoh Y.H. Terrett L. Terry L. Tetla D. Tewari S. Tewkesbury D. Texeira J. Tey C.L. Thakker C. Thakker M. Thatcher H. Thayanandan A. Thazhatheyil K. Thein E. Theocharidou L. Thet P. Thevarajah K. Thevendra M. Phoo T.N. Thirlwall Y. Thirumaran M. Thomas A. Thomas A. Thomas C. Thomas E. Thomas E. Thomas E. Thomas H. Thomas J. Thomas K. Thomas K. Thomas L. Thomas R. Thomas R. Thomas R. Thomas R. Thomas S. Thomas S. Thomas T. Thomas V. Thomas-Turner R. Thompson C. Thompson C. Thompson C. Thompson F. Thompson K. Thompson L. Thompson L. Thompson L. Thompson M. Thompson O. Thompson R. Thompson R. Thomson N. Thorn N. Thorne C. Thorne N. Thornton D. Thornton J. Thornton R. Thornton S. Thornton S. Thornton T. Thornton T. Thorpe C. Thorpe S. Thozthumparambil P. Thrasyvoulou L. Thraves H. Thwaiotes V. Thwaites G. Tiberi S. Tieger S. Tierney C. Tierney C. Tighe M. Tilbey S. Tiller A. Timerick J. Timlick E. Timmis A. Timms H. Timoroksa A-M. Tinashe S. Tinkler H. Tinkler M. Trafford T.M. Tipper J. Tivenan H. T-Michael H. Todd A. Todd J. Todd S. Tohfa M. Tolson M. Tomas A.L. Tomasova N. Tomlin S. Tomlins S. Tomlinson J. Tonkin J. Tonna I. Toohey C. Topham K. Topping M. Tousis R. Tovey P. Towersey G. Townley J. Townsend A. Tozer R. Tranter H. Travill C. Traynor S. Tridente A. Triggs S. Trim F. Trimmings A. Trinick T. Troedson S. Tropman E. Trotter A. Stannard T.M. Trudgill N. Truell R. Truslove M. Trussell S. Trussell T. Tsakiridou K. Tsang C. Tsang H.P. Tsang P. Tsawayo T. Tsilimpari K.K. Tsinaslanidis G. Tso S. Tucker S. Tufail A. Tully R. Tunesi G. Turbitt K. Turel R. Turgut T. Turley C. Turnbull A. Turner A. Turner A. Turner C. Turner G. Turner K. Turner K. Turner L. Turner M. Turner P. Turner S. Turner S. Turner V. Turney S. Turvey J. Tweed C. Tweed D. Twemlow R. Twohey E. Tyagi B. Tyagi V. Tyer A. Tyler J. Tyler J. Tyzack A. Tzavaras P. Uddin M.S. Uddin R. Uddin R. Hassan u.W. Ullah S. Ullah S. Ullah S. Um J. Umaipalan A. Umeadi J. Umeh A. Umeojiako W. Ummat B. Underwood C. Underwood J. Unsworth A. Uppal V.S. Upson G. Rasool U.M. Urruela S. Uru H. Usher M. Usher R. UsherRea A. Ustianowski A. Vaccari L.C. Vaghela U. Vaidya A. Valecka B. Valentine J. Valeria B. Vallabhaneni P. Vamplew L. Vamvakiti E. Vamvakopoulos J. van de Venne M. van der Meer A. van der Stelt N. Vance-Daniel J. Vancheeswaran R. Vandeyoon S.I. Vankayalapati P. Vanmali P. Vansomeren C. Van’t Hoff W. Vara S. Vardy S.J. Varghese A. Varghese M. Varney W. Varnier G. Vasadi V. Vass O. Vasu V. Vasudevan V. Vatish M. Vayalaman H. Vaz C. Veale N. Veerasamy S. Velankar S. Velauthar L. Veli N. Vella N. Velusamy A. Venables I. Venditti M. Venkataramakrishnan R. Venn R. Venn R. Ventilacion L. Vere J. Veres M. Vergnano S. Verling W. Verma A. Vernall R. Vernon B. Vertue M. Verula J. Vethanayagam N. Veys L. Vickers C. Victor S. Vidaillac C. Vidler J. Vijayakumar B. Nalini V.V.W. Vilcinskaite B. Vilimiene N. Vinall L. Vinay S. Vinayakarao L. Vincent R. Vincent R. Virdee P. Virgilio E. Virk A.M. Visentin E. Vithian K. Vittoria S. Vlad E. Vlies B. Vuylsteke A. Vyras E. Wach R. Wadams B. Wadd S. Waddington N. Wade P. Wadsworth K. Wafa S.E.I. Wagstaff D. Wagstaff L. Wahab D. Wahbi Z. Adigun W.A. Waidyanatha S. Wake R. Wakefield A. Wakeford W. Wakinshaw F. Walden A. Walding L. Waldron A. Walker G. Walker H. Walker I. Walker K. Walker K. Walker L. Walker O. Walker R. Walker R. Walker S. Wallbutton R. Wallen J. Wallendszus K. Waller A. Waller R. Wallis G. Wallis G. Wallis L. Walsh D. Walsh E. Walsh L. Walstow D. Walter D. Walters A. Walters H. Walters J. Walters J. Walton E. Walton L. Walton O. Walton S. Walton S. Wan M. Wan T. Wanda J. Wands M. Wane R. Wang F. Wang N. Wang R. Warbrick D. Warburton S. Ward D. Ward E. Ward J. Ward L. Ward N. Ward R. Ward T. Ward T. Warden S.A. Wardle S. Wardy H. Waring S. Warmington J. Warner B. Warner C. Warnock L. Warran S. Warren J. Warren L. Warren Y. Warren-Miell H. Warris A. Warwick G. Watchorn H.J. Waterfall H. Waters A. Waters D. Waterstone M. Watkins C. Watkins C. Watkins E. Watkins K. Watkins L. Watson A. Watson A.J.R. Watson E. Watson E. Watson J.G.R. Watson P. Watson R. Watson R. Watters M. Watterson D. Watts D. Watts J. Watts M. Waugh V. Wayman E. Wazir A. Weatherhead M. Weatherly N. Webb H. Webb K. Webb K. Webb S. Websdale C. Webster D. Webster I. Webster T. Wee L. Weerakoon R. Weerasinghe T. Weeratunga J. Weetman M. Wei S. Weichert I. Weinreich D.M. Welch H. Welch J. Welch L. Welch S. Welford A. Weller S. Wellings L. Wells B. Wellstead S. Welsh B. Welsh R. Welters I. Welton R. Wentworth L. Wesseldine K. West M. West R. West R. West S. Western L. Westhead R. Weston H. Westwood A. Wetherill B. Wheaver S. Wheeler H. Whelan B. Whelband M. Whileman A. Whitcher A. White A. White B. White C. White D. White H. White J. White J. White K. White M. White N. White S. White S. White T. Whitehead C. Whitehouse A. Whitehouse C. Whitehouse T. Whiteley J. Whiteley S. Whitlingum G. Whitmore D. Whittaker E. Whittam L. Whittington A. Whittle H. Whittle R. Wiafe E. Wiblin L. Wickens O. Widdrington J. Wieboldt J. Wieringa H. Wiesender C. Wiffen L. Wight A. Wignall C. Wilcock D. Wilcock E. Wilcox L. Wild L. Wild S. Wilde M. Wilding P. Wildsmith T. Wileman J. Wiles J. Wiles K. Wilhelmsen E. Wiliams T. Wilkie J. Wilkin D. Wilkins H. Wilkins J. Wilkins S. Wilkinson I. Wilkinson L. Wilkinson N. Wilkinson S. Wilkinson S. Wilkinson T. Willetts S. Williams A. Williams A. Williams A. Williams A. Williams A. Williams C. Williams C.V. Williams C. Williams D. Williams G. Williams G. Williams G. Williams H. Williams J. Williams J. Williams J. Williams J. Williams K. Williams K. Williams M. Williams M. Williams P. Williams P. Williams R. Williams S. Williams S. Williams S. Williams T. Williamson A. Williamson C. Williamson C. Williamson D. Williamson J.D. Williamson J. Williamson R. Williamson H. Willis E. Willis E. Willis H. Willis H. Willis J. Wills L. Willsher L. Willshire C. Willson F. Wilson A. Wilson A. Wilson A. Wilson B. Wilson J. Wilson K. Wilson K. Wilson L. Wilson M. Wilson T. Win M. Win T.T. Win W.Y. Winckworth L. Winder L. Winder P. Winmill H. Winn S. Winpenny C. Winslow H. Winter H. Winter J. Winter-Goodwin B. Wisdom S. Wise M. Wiselka M. Wiseman R. Wiseman S. Wishart S. Witele E. Withers N. Wittes J. Wixted D. Wodehouse T. Wolf W. Wolff N. Wolffsohn K. Wolf-Roberts R. Wolna M. Wolodimeroff E. Wolstencroft A. Wong A. Wong C. Wong C-H. Wong C-M. Wong E. Wong J.S.Y. Wong K.Y. Wong M.Y. Wong N. Wong S. Wood A. Wood C. Wood D. Wood F. Wood H. Wood J. Wood J. Wood L. Wood L. Wood S. Wood T. Woodall K. Woodfield R. Woodford C. Woodford E. Woodford J. Woodhead L. Woodhead T. Woodland P. Woodman M. Woods J. Woods K. Woods S. Woodward Z. Woolcock M. Wooldridge G. Woolf R. Woollard C. Woollard C. Woollen L. Woolley E. Woolley J. Woosey D. Wootton D. Wootton J. Worley D. Worton S. Wraight J. Wray M. Wren K. Wren L. Brown W.C. Wright C. Wright D. Wright F. Wright I. Wright L. Wright R. Wright S. Wright T. Wroe C. Wroe H. Wu H. Wu P. Wu P. Wubetu J. Wulandari F. Wulandari R. Wyatt C. Wyn-Griffiths F. Wynter I. Xavier B. Xhikola A. Xia Z. Xiao H. Yakubi M. Yan M. Yang F. Yang Y. Yanney M. Yap W.L. Yaqoob N. Yasmin S. Yates B. Yates D. Yates E. Yates H. Yates T. Yates M. Martin Y.C. Yein K. Yelnoorkar F. Yew P. Ylquimiche L. Melly Y.L. Ynter I. Yong H. Yorke J. Youens J. Ibrahim Y.A. Young E. Young G. Young L. Yousafzar A. Youssouf S. Yousuf A. Yu C. Yung B. Yusef D. Yusef S. Yusuf I. Zafar A-S. Zagalo S. Zaher S. Zahoor A. Zaki K. Zakir N. Zalewska K. Zamalloa A. Zaman M. Zaman S. Zamikula J. Zammit L. Zammit-Mangion M. Zebracki E. Zehnder D. Zeidan L. Zhao X. Zheng D. Zhu D. Zia M. Zibdeh O. Zill-E-Huma R. Zin E.T. Zinkin E. Zinyemba V. Zipitis C. Zmierczak A. Zubir A. Zuhra N. Zulaikha R. Zulfikar S. Zullo C. Zuriaga-Alvaro A. Zyengi S. Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): A randomised, controlled, open-label, platform trial. Lancet 2022 399 10325 665 676 10.1016/S0140‑6736(22)00163‑5 35151397
    [Google Scholar]
  21. Anwar H. Khan Q.U. Nadeem N. Pervaiz I. Ali M. Cheema F.F. Epileptic seizures. Discoveries 2020 8 2 e110 10.15190/d.2020.7 32577498
    [Google Scholar]
  22. Hussein AF Arunkumar N Gomes C Focal and Non-Focal Epilepsy Localization: A Review. IEEE Access 2018 6 49306 49324 10.1109/ACCESS.2018.2867078
    [Google Scholar]
  23. Ghulaxe Y. Joshi A. Chavada J. Huse S. Kalbande B. Sarda P.P. Understanding focal seizures in adults: A comprehensive review. Cureus 2023 15 11 e48173 10.7759/cureus.48173 38046728
    [Google Scholar]
  24. Mukherjee S. Ali S. Hashmi S. History, Origin and Types of Neurological Disorders. Applications of Stem Cells and derived Exosomes in Neurodegenerative Disorders Springer Nature Singapore. Jahan S. Siddiqui A.J. Singapore Springer Nature Singapore 2023 1 32 10.1007/978‑981‑99‑3848‑3_1
    [Google Scholar]
  25. Balestrini S. Arzimanoglou A. Blümcke I. Scheffer I.E. Wiebe S. Zelano J. Walker M.C. The aetiologies of epilepsy. Epileptic Disord. 2021 23 1 1 16 10.1684/epd.2021.1255 33720020
    [Google Scholar]
  26. Courson J. Quoy M. Timofeeva Y. Manos T. An exploratory computational analysis in mice brain networks of widespread epileptic seizure onset locations along with potential strategies for effective intervention and propagation control. Front. Comput. Neurosci. 2024 18 1360009 10.3389/fncom.2024.1360009 38468870
    [Google Scholar]
  27. Broughton R.J. The parasomnias and sleep related movement disorders—a look back at six decades of scientific studies. Clin. Trans. Neurosci. 2022 6 1 3 10.3390/ctn6010003
    [Google Scholar]
  28. Yacubian E.M.T. Kakooza-Mwesige A. Singh G. Carpio A. Figueiredo d.N.V. Saute L.R. Marques de Haes T. Common infectious and parasitic diseases as a cause of seizures: Geographic distribution and contribution to the burden of epilepsy. Epileptic Disord. 2022 24 6 994 1019 10.1684/epd.2022.1491 36219093
    [Google Scholar]
  29. Vorderwülbecke B.J. Wandschneider B. Weber Y. Holtkamp M. Genetic generalized epilepsies in adults — challenging assumptions and dogmas. Nat. Rev. Neurol. 2022 18 2 71 83 10.1038/s41582‑021‑00583‑9 34837042
    [Google Scholar]
  30. Berg A.T. Scheffer I.E. New concepts in classification of the epilepsies: Entering the 21st century. Epilepsia 2011 52 6 1058 1062 10.1111/j.1528‑1167.2011.03101.x 21635233
    [Google Scholar]
  31. Riva A. Golda A. Balagura G. Amadori E. Vari M.S. Piccolo G. Iacomino M. Lattanzi S. Salpietro V. Minetti C. Striano P. New trends and most promising therapeutic strategies for epilepsy treatment. Front. Neurol. 2021 12 753753 10.3389/fneur.2021.753753 34950099
    [Google Scholar]
  32. Falls N. Arango J.I. Adelson P.D. Responsive neurostimulation in pediatric patients with drug-resistant epilepsy. Neurosurg. Focus 2022 53 4 E9 10.3171/2022.7.FOCUS22339 36183178
    [Google Scholar]
  33. Lasoń W. Chlebicka M. Rejdak K. Research advances in basic mechanisms of seizures and antiepileptic drug action. Pharmacol. Rep. 2013 65 4 787 801 10.1016/S1734‑1140(13)71060‑0 24145073
    [Google Scholar]
  34. Bonansco C. Fuenzalida M. Plasticity of hippocampal excitatory-inhibitory balance: Missing the synaptic control in the epileptic brain. Neural Plast. 2016 2016 1 13 10.1155/2016/8607038 27006834
    [Google Scholar]
  35. Walker C.M. Surges R. Mechanisms of Antiepileptic Drug Action. The Treatment of Epilepsy. 1st Ed. Shorvon S. Perucca E. Engel J. New York Wiley 2015 1 91
    [Google Scholar]
  36. Deeb T.Z. Maguire J. Moss S.J. Possible alterations in GABA A receptor signaling that underlie benzodiazepine‐resistant seizures. Epilepsia 2012 53 s9 Suppl. 9 79 88 10.1111/epi.12037 23216581
    [Google Scholar]
  37. Lin Y. Wang Y. Neurostimulation as a promising epilepsy therapy. Epilepsia Open 2017 2 4 371 387 10.1002/epi4.12070 29588969
    [Google Scholar]
  38. Edwards C.A. Kouzani A. Lee K.H. Ross E.K. Neurostimulation devices for the treatment of neurologic disorders. Mayo Clin. Proc. 2017 92 9 1427 1444 10.1016/j.mayocp.2017.05.005 28870357
    [Google Scholar]
  39. Conway C.R. Colijn M.A. Schachter S.C. Vagus Nerve Stimulation for Epilepsy and Depression. Brain Stimulation. 1st Ed. Reti I.M. New York Wiley 2015 305 335 10.1002/9781118568323.ch17
    [Google Scholar]
  40. Jarosiewicz B. Morrell M. The RNS System: Brain-responsive neurostimulation for the treatment of epilepsy. Expert Rev. Med. Devices 2021 18 2 129 138 10.1080/17434440.2019.1683445 32936673
    [Google Scholar]
  41. Krauss J.K. Lipsman N. Aziz T. Boutet A. Brown P. Chang J.W. Davidson B. Grill W.M. Hariz M.I. Horn A. Schulder M. Mammis A. Tass P.A. Volkmann J. Lozano A.M. Technology of deep brain stimulation: Current status and future directions. Nat. Rev. Neurol. 2021 17 2 75 87 10.1038/s41582‑020‑00426‑z 33244188
    [Google Scholar]
  42. Ułamek-Kozioł M. Czuczwar S.J. Januszewski S. Pluta R. Ketogenic Diet and Epilepsy. Nutrients 2019 11 10 2510 10.3390/nu11102510 31635247
    [Google Scholar]
  43. Brouns F. Overweight and diabetes prevention: Is a low-carbohydrate–high-fat diet recommendable? Eur. J. Nutr. 2018 57 4 1301 1312 10.1007/s00394‑018‑1636‑y 29541907
    [Google Scholar]
  44. Poff A.M. Rho J.M. D’Agostino D.P. Ketone administration for seizure disorders: History and rationale for ketone esters and metabolic alternatives. Front. Neurosci. 2019 13 1041 10.3389/fnins.2019.01041 31680801
    [Google Scholar]
  45. Katsu-Jiménez Y. Alves R.M.P. Giménez-Cassina A. Food for thought: Impact of metabolism on neuronal excitability. Exp. Cell Res. 2017 360 1 41 46 10.1016/j.yexcr.2017.03.002 28263755
    [Google Scholar]
  46. Roehl K. Falco-Walter J. Ouyang B. Balabanov A. Modified ketogenic diets in adults with refractory epilepsy: Efficacious improvements in seizure frequency, seizure severity, and quality of life. Epilepsy Behav. 2019 93 113 118 10.1016/j.yebeh.2018.12.010 30867113
    [Google Scholar]
  47. Anyanwu C. Motamedi G. Diagnosis and surgical treatment of drug-resistant epilepsy. Brain Sci. 2018 8 4 49 10.3390/brainsci8040049 29561756
    [Google Scholar]
  48. Englot D.J. Chang E.F. Rates and predictors of seizure freedom in resective epilepsy surgery: An update. Neurosurg. Rev. 2014 37 3 389 405 10.1007/s10143‑014‑0527‑9 24497269
    [Google Scholar]
  49. Consales A. Casciato S. Asioli S. Barba C. Caulo M. Colicchio G. Cossu M. Palma d.L. Morano A. Vatti G. Villani F. Zamponi N. Tassi L. Gennaro D.G. Marras C.E. The surgical treatment of epilepsy. Neurol. Sci. 2021 42 6 2249 2260 10.1007/s10072‑021‑05198‑y 33797619
    [Google Scholar]
  50. Moshé S.L. Perucca E. Ryvlin P. Tomson T. Epilepsy: New advances. Lancet 2015 385 9971 884 898 10.1016/S0140‑6736(14)60456‑6 25260236
    [Google Scholar]
  51. Niriayo Y.L. Gebregziabher T. Demoz G.T. Tesfay N. Gidey K. Drug therapy problems and contributing factors among patients with epilepsy. PLoS One 2024 19 3 e0299968 10.1371/journal.pone.0299968 38451979
    [Google Scholar]
  52. Bayat A. Bayat M. Rubboli G. Møller R.S. Epilepsy syndromes in the first year of life and usefulness of genetic testing for precision therapy. Genes 2021 12 7 1051 10.3390/genes12071051 34356067
    [Google Scholar]
  53. Dalic L. Cook M. Managing drug-resistant epilepsy: Challenges and solutions. Neuropsychiatr. Dis. Treat. 2016 12 2605 2616 10.2147/NDT.S84852 27789949
    [Google Scholar]
  54. Benbadis S.R. Geller E. Ryvlin P. Schachter S. Wheless J. Doyle W. Vale F.L. Putting it all together: Options for intractable epilepsy. Epilepsy Behav. 2018 88 33 38 10.1016/j.yebeh.2018.05.030 30241957
    [Google Scholar]
  55. Sisodiya S.M. Precision medicine and therapies of the future. Epilepsia 2021 62 S2 Suppl. 2 S90 S105 10.1111/epi.16539 32776321
    [Google Scholar]
  56. Lavin B. Dormond C. Scantlebury M.H. Frouin P.Y. Brodie M.J. Bridging the healthcare gap: Building the case for epilepsy virtual clinics in the current healthcare environment. Epilepsy Behav. 2020 111 107262 10.1016/j.yebeh.2020.107262 32645620
    [Google Scholar]
  57. Leal G.B. Barros-Barbosa A. Ferreirinha F. Chaves J. Rangel R. Santos A. Carvalho C. Martins-Ferreira R. Samões R. Freitas J. Lopes J. Ramalheira J. Lobo M.G. Martins da Silva A. Costa P.P. Correia-de-Sá P. Mesial temporal lobe epilepsy (mtle) drug-refractoriness is associated with p2x7 receptors overexpression in the human hippocampus and temporal neocortex and may be predicted by low circulating levels of mir-22. Front. Cell. Neurosci. 2022 16 910662 10.3389/fncel.2022.910662 35875355
    [Google Scholar]
  58. Uslu G.S. Yuksel B. Tekin B. Sariahmetoglu H. Atakli D. Cognitive impairment and drug responsiveness in mesial temporal lobe epilepsy. Epilepsy Behav. 2019 90 162 167 10.1016/j.yebeh.2018.10.034 30576963
    [Google Scholar]
  59. French J.A. Kanner A.M. Bautista J. Abou-Khalil B. Browne T. Harden C.L. Theodore W.H. Bazil C. Stern J. Schachter S.C. Bergen D. Hirtz D. Montouris G.D. Nespeca M. Gidal B. Marks W.J. Jr Turk W.R. Fischer J.H. Bourgeois B. Wilner A. Faught R.E. Jr Sachdeo R.C. Beydoun A. Glauser T.A. Efficacy and tolerability of the new antiepileptic drugs II: Treatment of refractory epilepsy: Report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2004 62 8 1261 1273 10.1212/01.WNL.0000123695.22623.32 15111660
    [Google Scholar]
  60. Sheng J. Liu S. Qin H. Li B. Zhang X. Drug-resistant epilepsy and surgery. Curr. Neuropharmacol. 2018 16 1 17 28 28474565
    [Google Scholar]
  61. Zaitsev А.V. Amakhin D.V. Dyomina A.V. Zakharova M.V. Ergina J.L. Postnikova T.Y. Diespirov G.P. Magazanik L.G. Synaptic dysfunction in epilepsy. J. Evol. Biochem. Physiol. 2021 57 3 542 563 10.1134/S002209302103008X
    [Google Scholar]
  62. Ghit A. Assal D. Shami A.A.S. Hussein D.E.E. GABAA receptors: Structure, function, pharmacology, and related disorders. J. Genet. Eng. Biotechnol. 2021 19 1 123 10.1186/s43141‑021‑00224‑0 34417930
    [Google Scholar]
  63. Kaur S. Singh S. Arora A. Pharmacology of GABA and Its Receptors. Frontiers in Pharmacology of Neurotransmitters Springer Singapore. Kumar P. Deb P.K. Singapore Springer Nature Singapore 2020 241 292 10.1007/978‑981‑15‑3556‑7_8
    [Google Scholar]
  64. Perucca E. Bialer M. White H.S. New GABA-targeting therapies for the treatment of seizures and epilepsy: I. role of gaba as a modulator of seizure activity and recently approved medications acting on the gaba system. CNS Drugs 2023 37 9 755 779 10.1007/s40263‑023‑01027‑2 37603262
    [Google Scholar]
  65. Cherubini E. Cristo D.G. Avoli M. Dysregulation of gabaergic signaling in neurodevelomental disorders: Targeting cation-chloride co-transporters to re-establish a proper E/I balance. Front. Cell. Neurosci. 2022 15 813441 10.3389/fncel.2021.813441 35069119
    [Google Scholar]
  66. Greenfield L.J. Jr Molecular mechanisms of antiseizure drug activity at GABAA receptors. Seizure 2013 22 8 589 600 10.1016/j.seizure.2013.04.015 23683707
    [Google Scholar]
  67. Chen T.S. Huang T.H. Lai M.C. Huang C.W. The role of glutamate receptors in epilepsy. Biomedicines 2023 11 3 783 10.3390/biomedicines11030783 36979762
    [Google Scholar]
  68. Takago H. Oshima-Takago T. Pre- and postsynaptic ionotropic glutamate receptors in the auditory system of mammals. Hear. Res. 2018 362 1 13 10.1016/j.heares.2018.02.007 29510886
    [Google Scholar]
  69. Chiechio S. Modulation of Chronic Pain by Metabotropic Glutamate Receptors. Adv. Pharma. 2016 75 63 89 10.1016/bs.apha.2015.11.001
    [Google Scholar]
  70. Sumadewi K.T. Harkitasari S. Tjandra D.C. Biomolecular mechanisms of epileptic seizures and epilepsy: A review. Acta Epileptologica 2023 5 1 28 10.1186/s42494‑023‑00137‑0
    [Google Scholar]
  71. Celli R. Fornai F. Targeting ionotropic glutamate receptors in the treatment of epilepsy. Curr. Neuropharmacol. 2021 19 6 747 765 10.2174/18756190MTA5DNTcey 32867642
    [Google Scholar]
  72. Lau A. Tymianski M. Glutamate receptors, neurotoxicity and neurodegeneration. Pflugers Arch. 2010 460 2 525 542 10.1007/s00424‑010‑0809‑1 20229265
    [Google Scholar]
  73. He L.Y. Hu M.B. Li R.L. Zhao R. Fan L.H. He L. Lu F. Ye X. Huang Y. Wu C.J. Natural medicines for the treatment of epilepsy: Bioactive components, pharmacology and mechanism. Front. Pharmacol. 2021 12 604040 10.3389/fphar.2021.604040 33746751
    [Google Scholar]
  74. Duflocq A. Bras L.B. Bullier E. Couraud F. Davenne M. Nav1.1 is predominantly expressed in nodes of Ranvier and axon initial segments. Mol. Cell. Neurosci. 2008 39 2 180 192 10.1016/j.mcn.2008.06.008 18621130
    [Google Scholar]
  75. Contet C. Goulding S.P. Kuljis D.A. BK channels in the central nervous system. Intern. Rev. Neurob. 2016 128 281 342 10.1016/bs.irn.2016.04.001
    [Google Scholar]
  76. Fernandez-Abascal J. Graziano B. Encalada N. Glial Chloride Channels in the Function of the Nervous System Across Species. Ion Channels in Biophysics and Physiology Singapore Springer Nature Singapore 2021 195 223 10.1007/978‑981‑16‑4254‑8_10
    [Google Scholar]
  77. Martin A.D. Stirling W.J. Thorne R.S. Watt G. Uncertainties on α S in global PDF analyses and implications for predicted hadronic cross sections. Eur. Phys. J. C 2009 64 4 653 680 10.1140/epjc/s10052‑009‑1164‑2
    [Google Scholar]
  78. Wei F. Yan L.M. Su T. He N. Lin Z.J. Wang J. Shi Y.W. Yi Y.H. Liao W.P. Ion channel genes and epilepsy: Functional alteration, pathogenic potential, and mechanism of epilepsy. Neurosci. Bull. 2017 33 4 455 477 10.1007/s12264‑017‑0134‑1 28488083
    [Google Scholar]
  79. Skaper S.D. Debetto P. Giusti P. The P2X 7 purinergic receptor: From physiology to neurological disorders. FASEB J. 2010 24 2 337 345 10.1096/fj.09‑138883 19812374
    [Google Scholar]
  80. North RA P2X receptors. Philos Trans R Soc B Biol Sci. 1700 37 1700 20150427
    [Google Scholar]
  81. Burnstock G. Knight G.E. The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression. Purinergic Signal. 2018 14 1 1 18 10.1007/s11302‑017‑9593‑0 29164451
    [Google Scholar]
  82. Calzaferri F. Ruiz-Ruiz C. Diego d.A.M.G. Pascual d.R. Méndez-López I. Cano-Abad M.F. Maneu V. Ríos l.d.C. Gandía L. García A.G. The purinergic P2X7 receptor as a potential drug target to combat neuroinflammation in neurodegenerative diseases. Med. Res. Rev. 2020 40 6 2427 2465 10.1002/med.21710 32677086
    [Google Scholar]
  83. Gil B. Smith J. Tang Y. Illes P. Engel T. Beyond seizure control: Treating comorbidities in epilepsy via targeting of the p2x7 receptor. Int. J. Mol. Sci. 2022 23 4 2380 10.3390/ijms23042380 35216493
    [Google Scholar]
  84. Kulesza A. Paczek L. Burdzinska A. The role of COX-2 and PGE2 in the regulation of immunomodulation and other functions of mesenchymal stromal cells. Biomedicines 2023 11 2 445 10.3390/biomedicines11020445 36830980
    [Google Scholar]
  85. Chen Y. Nagib M.M. Yasmen N. Sluter M.N. Littlejohn T.L. Yu Y. Jiang J. Neuroinflammatory mediators in acquired epilepsy: An update. Inflamm. Res. 2023 72 4 683 701 10.1007/s00011‑023‑01700‑8 36745211
    [Google Scholar]
  86. Rawat C. Kukal S. Dahiya U.R. Kukreti R. Cyclooxygenase-2 (COX-2) inhibitors: Future therapeutic strategies for epilepsy management. J. Neuroinflammation 2019 16 1 197 10.1186/s12974‑019‑1592‑3 31666079
    [Google Scholar]
  87. Ferrer M.D. Busquets-Cortés C. Capó X. Tejada S. Tur J.A. Pons A. Sureda A. Cyclooxygenase-2 inhibitors as a therapeutic target in inflammatory diseases. Curr. Med. Chem. 2019 26 18 3225 3241 10.2174/0929867325666180514112124 29756563
    [Google Scholar]
  88. Elbadawy M. Usui T. Yamawaki H. Sasaki K. Novel functions of death-associated protein kinases through mitogen-activated protein kinase-related signals. Int. J. Mol. Sci. 2018 19 10 3031 10.3390/ijms19103031 30287790
    [Google Scholar]
  89. Gan C.L. Zou Y. Chen D. Shui X. Hu L. Li R. Zhang T. Wang J. Mei Y. Wang L. Zhang M. Tian Y. Gu X. Lee T.H. Blocking ERK-DAPK1 axis attenuates glutamate excitotoxicity in epilepsy. Int. J. Mol. Sci. 2022 23 12 6370 10.3390/ijms23126370 35742817
    [Google Scholar]
  90. Saadi A.MSM The expression pattern of death associated protein kinase1 in normal dorsal root ganglion neurons and following peripheral nerve injury. Theses. 2015 251
    [Google Scholar]
  91. Noori T. Shirooie S. Sureda A. Sobarzo-Sanchez E. Dehpour A.R. Saldías M. Akkol E.K. Regulation of DAPK1 by natural products: An important target in treatment of stroke. Neurochem. Res. 2022 47 8 2142 2157 10.1007/s11064‑022‑03628‑7 35674928
    [Google Scholar]
  92. Kim N. Chen D. Zhou X.Z. Lee T.H. Death-associated protein kinase 1 phosphorylation in neuronal cell death and neurodegenerative disease. Int. J. Mol. Sci. 2019 20 13 3131 10.3390/ijms20133131 31248062
    [Google Scholar]
  93. Zhang F. Kang Z. Li W. Xiao Z. Zhou X. Roles of brain-derived neurotrophic factor/tropomyosin-related kinase B (BDNF/TrkB) signalling in Alzheimer’s disease. J. Clin. Neurosci. 2012 19 7 946 949 10.1016/j.jocn.2011.12.022 22613489
    [Google Scholar]
  94. Singh S. Singh T.G. Rehni A.K. An insight into molecular mechanisms and novel therapeutic approaches in epileptogenesis. CNS Neurol. Disord. Drug Targets 2021 19 10 750 779 10.2174/1871527319666200910153827 32914725
    [Google Scholar]
  95. Batool Z. Azfal A. Liaquat L. Receptor tyrosine kinases (rtks). in: Receptor tyrosine kinases in neurodegenerative and psychiatric disorders Elsevier. Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders. New York Academic Press 2023 117 185
    [Google Scholar]
  96. Munguia-Galaviz F.J. Miranda-Diaz A.G. Cardenas-Sosa M.A. Echavarria R. Sigma-1 receptor signaling: In search of new therapeutic alternatives for cardiovascular and renal diseases. Int. J. Mol. Sci. 2023 24 3 1997 10.3390/ijms24031997 36768323
    [Google Scholar]
  97. Gliwińska A. Czubilińska-Łada J. Więckiewicz G. Świętochowska E. Badeński A. Dworak M. Szczepańska M. The role of brain-derived neurotrophic factor (bdnf) in diagnosis and treatment of epilepsy, depression, schizophrenia, anorexia nervosa and alzheimer’s disease as highly drug-resistant diseases: A narrative review. Brain Sci. 2023 13 2 163 10.3390/brainsci13020163 36831706
    [Google Scholar]
  98. Amantea D. Russo R. Certo M. Rombolà L. Adornetto A. Morrone L.A. Corasaniti M.T. Bagetta G. Caspase-1-independent Maturation of IL-1β in Ischemic Brain Injury: Is there a Role for Gelatinases? Mini Rev. Med. Chem. 2016 16 9 729 737 10.2174/1389557516666160321112512 26996625
    [Google Scholar]
  99. Rijkers K. Majoie H.J. Hoogland G. Kenis G. Baets D.M. Vles J.S. The role of interleukin-1 in seizures and epilepsy: A critical review. Exp. Neurol. 2009 216 2 258 271 10.1016/j.expneurol.2008.12.014 19162013
    [Google Scholar]
  100. Rutter J. Mechanisms of interleukin-1 signalling in the regulation of seizures - proquest. 2024 Available from: https://www.proquest.com/openview/353662674d31fba139ad7c9d58644a93/1?pq-origsite=gscholar&cbl=2026366&diss=y
  101. Yamanaka G. Ishida Y. Kanou K. Suzuki S. Watanabe Y. Takamatsu T. Morichi S. Go S. Oana S. Yamazaki T. Kawashima H. Towards a treatment for neuroinflammation in epilepsy: Interleukin-1 receptor antagonist, anakinra, as a potential treatment in intractable epilepsy. Int. J. Mol. Sci. 2021 22 12 6282 10.3390/ijms22126282 34208064
    [Google Scholar]
  102. Wang P. Qian H. Xiao M. Lv J. Role of signal transduction pathways in IL‐1β‐induced apoptosis: Pathological and therapeutic aspects. Immun. Inflamm. Dis. 2023 11 1 e762 10.1002/iid3.762 36705417
    [Google Scholar]
  103. Gibbons J.J. Abraham R.T. Yu K. Mammalian target of rapamycin: Discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth. Semin. Oncol. 2009 36 Suppl. 3 S3 S17 10.1053/j.seminoncol.2009.10.011 19963098
    [Google Scholar]
  104. LaSarge C.L. Danzer S.C. Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation. Front. Mol. Neurosci. 2014 7 18 10.3389/fnmol.2014.00018 24672426
    [Google Scholar]
  105. Bockaert J. Marin P. mTOR in brain physiology and pathologies. Physiol. Rev. 2015 95 4 1157 1187 10.1152/physrev.00038.2014 26269525
    [Google Scholar]
  106. Citraro R. Leo A. Constanti A. Russo E. Sarro D.G. mTOR pathway inhibition as a new therapeutic strategy in epilepsy and epileptogenesis. Pharmacol. Res. 2016 107 333 343 10.1016/j.phrs.2016.03.039 27049136
    [Google Scholar]
  107. Kang T.C. Nuclear factor-erythroid 2-related factor 2 (NRF2) and mitochondrial dynamics/mitophagy in neurological diseases. Antioxidants 2020 9 7 617 10.3390/antiox9070617 32679689
    [Google Scholar]
  108. Ma Q. Role of nrf2 in oxidative stress and toxicity. Annu. Rev. Pharmacol. Toxicol. 2013 53 1 401 426 10.1146/annurev‑pharmtox‑011112‑140320 23294312
    [Google Scholar]
  109. Otsuki A. Yamamoto M. Cis-element architecture of Nrf2–sMaf heterodimer binding sites and its relation to diseases. Arch. Pharm. Res. 2020 43 3 275 285 10.1007/s12272‑019‑01193‑2 31792803
    [Google Scholar]
  110. Lastres-Becker I. García-Yagüe A.J. Scannevin R.H. Casarejos M.J. Kügler S. Rábano A. Cuadrado A. Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson’s Disease. Antioxid. Redox Signal. 2016 25 2 61 77 10.1089/ars.2015.6549 27009601
    [Google Scholar]
  111. Lu M.C. Ji J.A. Jiang Z.Y. You Q.D. The Keap1–Nrf2–ARE pathway as a potential preventive and therapeutic target: An update. Med. Res. Rev. 2016 36 5 924 963 10.1002/med.21396 27192495
    [Google Scholar]
  112. Yang N. Guan Q.W. Chen F.H. Xia Q.X. Yin X.X. Zhou H.H. Mao X.Y. Antioxidants targeting mitochondrial oxidative stress: Promising neuroprotectants for epilepsy. Oxid. Med. Cell. Longev. 2020 2020 1 14 10.1155/2020/6687185 33299529
    [Google Scholar]
  113. Madireddy S. Madireddy S. Therapeutic strategies to ameliorate neuronal damage in epilepsy by regulating oxidative stress, mitochondrial dysfunction, and neuroinflammation. Brain Sci. 2023 13 5 784 10.3390/brainsci13050784 37239256
    [Google Scholar]
  114. Hol E.M. Pekny M. Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system. Curr. Opin. Cell Biol. 2015 32 121 130 10.1016/j.ceb.2015.02.004 25726916
    [Google Scholar]
  115. Dodd S. Malhi G.S. Tiller J. Schweitzer I. Hickie I. Khoo J.P. Bassett D.L. Lyndon B. Mitchell P.B. Parker G. Fitzgerald P.B. Udina M. Singh A. Moylan S. Giorlando F. Doughty C. Davey C.G. Theodoros M. Berk M. A consensus statement for safety monitoring guidelines of treatments for major depressive disorder. Aust. N. Z. J. Psychiatry 2011 45 9 712 725 10.3109/00048674.2011.595686 21888608
    [Google Scholar]
  116. Hu Y. Qi H. Yang J. Wang F. Peng X. Chen X. Zhu X. Wogonin mitigates microglia-mediated synaptic over-pruning and cognitive impairment following epilepsy. Phytomedicine 2024 135 156222 10.1016/j.phymed.2024.156222 39547095
    [Google Scholar]
  117. Zhang X. Tang N. Hadden T.J. Akt, FoxO and regulation of apoptosis. Biochim Biophys Acta BBA - Mol. Cell Res. 2011 1813 11 1978 1986
    [Google Scholar]
  118. Huang X. Hu Q. Shi H. Zheng Y. Hu R. Guo Q. Everolimus inhibits PI3K/Akt/mTOR and NF-kB/IL-6 signaling and protects seizure-induced brain injury in rats. J. Chem. Neuroanat. 2021 114 101960 10.1016/j.jchemneu.2021.101960 33915267
    [Google Scholar]
  119. Wu J.B. Shih J.C. Valproic acid induces monoamine oxidase A via Akt/forkhead box O1 activation. Mol. Pharmacol. 2011 80 4 714 723 10.1124/mol.111.072744 21775495
    [Google Scholar]
  120. Song J. Li M. Kang N. Jin W. Xiao Y. Li Z. Qi Q. Zhang J. Duan Y. Feng X. Lv P. Baicalein ameliorates cognitive impairment of vascular dementia rats via suppressing neuroinflammation and regulating intestinal microbiota. Brain Res. Bull. 2024 208 110888 10.1016/j.brainresbull.2024.110888 38295883
    [Google Scholar]
  121. Zhang Y. Hu X. Zou L.Q. Flavonoids as therapeutic agents for epilepsy: Unveiling anti-inflammatory and antioxidant pathways for novel treatments. Front. Pharmacol. 2024 15 1457284 10.3389/fphar.2024.1457284 39329119
    [Google Scholar]
  122. Erdem S.A. Subak H. Aslan P. Surfactant-based electrodes for the quantification of flavonoids. Surfactant Based Electrochemical Sensors and Biosensors. London Elsevier 2024 443 469 10.1016/B978‑0‑443‑15493‑5.00014‑2
    [Google Scholar]
  123. Ghosh S. Bishal A. Ghosh S.K. Jana K. Gayen B. Sahu S. Debnath B. Herbal medicines: A potent approach to human diseases, their chief compounds, formulations, present status, and future aspects. Inter. J. Memb. Sci. Tech. 2023 10 1 442 464 10.15379/ijmst.v10i1.2608
    [Google Scholar]
  124. Ullah A. Munir S. Badshah S.L. Khan N. Ghani L. Poulson B.G. Emwas A.H. Jaremko M. Important flavonoids and their role as a therapeutic agent. Molecules 2020 25 22 5243 10.3390/molecules25225243 33187049
    [Google Scholar]
  125. Nassiri-Asl M. Hajiali F. Taghiloo M. Abbasi E. Mohseni F. Yousefi F. Comparison between the effects of quercetin on seizure threshold in acute and chronic seizure models. Toxicol. Ind. Health 2016 32 5 936 944 10.1177/0748233713518603 24442347
    [Google Scholar]
  126. Sefil F. Kahraman I. Dokuyucu R. Gokce H. Ozturk A. Tutuk O. Aydin M. Ozkan U. Pinar N. Ameliorating effect of quercetin on acute pentylenetetrazole induced seizures in rats. Int. J. Clin. Exp. Med. 2014 7 9 2471 2477 25356099
    [Google Scholar]
  127. Tomou E.M. Papakyriakopoulou P. Saitani E.M. Valsami G. Pippa N. Skaltsa H. Recent advances in nanoformulations for quercetin delivery. Pharmaceutics 2023 15 6 1656 10.3390/pharmaceutics15061656 37376104
    [Google Scholar]
  128. Wu D. Zheng Z. Fan S. Wen X. Han X. Wang S. Wang Y. Zhang Z. Shan Q. Li M. Hu B. Zheng Y. Lu J. Ameliorating effect of quercetin on epilepsy by inhibition of inflammation in glial cells. Exp. Ther. Med. 2020 20 2 854 859 10.3892/etm.2020.8742 32742328
    [Google Scholar]
  129. Prakash C. Tyagi J. Rabidas S.S. Kumar V. Sharma D. Therapeutic potential of quercetin and its derivatives in epilepsy: Evidence from preclinical studies. Neuromolecular Med. 2023 25 2 163 178 10.1007/s12017‑022‑08724‑z 35951285
    [Google Scholar]
  130. Ariede M.B. Junior G.W.A. Cândido T.M. Aguiar d.M.M.G.B. Rosado C. Rangel-Yagui C.O. Pessoa F.V.L.S. Velasco M.V.R. Baby A.R. Would rutin be a feasible strategy for environmental-friendly photoprotective samples? a review from stability to skin permeability and efficacy in sunscreen systems. Cosmetics 2024 11 4 141 10.3390/cosmetics11040141
    [Google Scholar]
  131. Calabrese E.J. Pressman P. Hayes A.W. Dhawan G. Kapoor R. Agathokleous E. Calabrese V. RUTIN, a widely consumed flavonoid, that commonly induces hormetic effects. Food Chem. Toxicol. 2024 187 114626 10.1016/j.fct.2024.114626 38556157
    [Google Scholar]
  132. Goyal J. Verma P.K. An overview of biosynthetic pathway and therapeutic potential of rutin. Mini Rev. Med. Chem. 2023 23 14 1451 1460 10.2174/1389557523666230125104101 36698235
    [Google Scholar]
  133. Satari A. Ghasemi S. Habtemariam S. Asgharian S. Lorigooini Z. Rutin: A flavonoid as an effective sensitizer for anticancer therapy; insights into multifaceted mechanisms and applicability for combination therapy. Evid. Based Complement. Alternat. Med. 2021 2021 1 10 10.1155/2021/9913179 34484407
    [Google Scholar]
  134. Chang A. Chang Y. Wang S.J. Rutin prevents seizures in kainic acid-treated rats: Evidence of glutamate levels, inflammation and neuronal loss modulation. Food Funct. 2022 13 20 10401 10414 10.1039/D2FO01490D 36148811
    [Google Scholar]
  135. Mohamed K.M. Abdelfattah M.S. khadragy E.M. Megrin A.W.A. Fehaid A. Kassab R.B. Moneim A.A.E. Rutin-loaded selenium nanoparticles modulated the redox status, inflammatory, and apoptotic pathways associated with pentylenetetrazole-induced epilepsy in mice. Green Processing and Synthesis 2023 12 1 20230010 10.1515/gps‑2023‑0010
    [Google Scholar]
  136. Rad SS Asl MN Zamansoltani F Anticonvulsive effects of rutin in a rat model of absence seizure: A novel compound to treat seizure. Anna. Gen. Psychiatry. 2008 7 Suppl 1 S219 10.1186/1744‑859X‑7‑S1‑S219
    [Google Scholar]
  137. Nieoczym D. Socała K. Raszewski G. Wlaź P. Effect of quercetin and rutin in some acute seizure models in mice. Prog. Neuropsychopharmacol. Biol. Psychiatry 2014 54 50 58 10.1016/j.pnpbp.2014.05.007 24857758
    [Google Scholar]
  138. Aseervatham G.S.B. Suryakala U. Doulethunisha Sundaram S. Bose P.C. Sivasudha T. Expression pattern of NMDA receptors reveals antiepileptic potential of apigenin 8-C-glucoside and chlorogenic acid in pilocarpine induced epileptic mice. Biomed. Pharmacother. 2016 82 54 64 10.1016/j.biopha.2016.04.066 27470339
    [Google Scholar]
  139. Hashemi P. Babaei F.J. Vazifekhah S. Nikbakht F. Evaluation of the neuroprotective, anticonvulsant, and cognition-improvement effects of apigenin in temporal lobe epilepsy: Involvement of the mitochondrial apoptotic pathway. Iran. J. Basic Med. Sci. 2019 22 7 752 758 32373296
    [Google Scholar]
  140. Kramer D.J. Johnson A.A. Apigenin: A natural molecule at the intersection of sleep and aging. Front. Nutr. 2024 11 1359176 10.3389/fnut.2024.1359176 38476603
    [Google Scholar]
  141. Bhratee A. Anand P. Singh S. Apigenin: Exploring its neuroprotective potential in neurodegenerative disorders: Mechanisms and promising therapeutic applications. Pharmaspire 2023 15 4 257 263 10.56933/Pharmaspire.2023.15138
    [Google Scholar]
  142. Yao L. Fan Z. Han S. Sun N. Che H. Apigenin acts as a partial agonist action at estrogen receptors in vivo. Eur. J. Pharmacol. 2021 906 174175 10.1016/j.ejphar.2021.174175 34048736
    [Google Scholar]
  143. Cheng Y. Zhang Y. Huang P. Cheng Q. Ding H. Luteolin ameliorates pentetrazole-induced seizures through the inhibition of the TLR4/NF-κB signaling pathway. Epilepsy Res. 2024 201 107321 10.1016/j.eplepsyres.2024.107321 38382229
    [Google Scholar]
  144. Tambe R. Patil A. Jain P. Sancheti J. Somani G. Sathaye S. Assessment of luteolin isolated from Eclipta alba leaves in animal models of epilepsy. Pharm. Biol. 2017 55 1 264 268 10.1080/13880209.2016.1260597 27927066
    [Google Scholar]
  145. Birman H. Dar A.K. Kapucu A. Acar S. Uzüm G. EffectsofLuteolinonLiver,KidneyandBraininPentylentetrazol-Induced Seizures: Involvement of Metalloproteinases and NOS Activities. Balkan Med. J. 2012 29 2 188 196 10.5152/balkanmedj.2011.030 25206993
    [Google Scholar]
  146. Shen M.L. Wang C.H. Chen R.Y.T. Zhou N. Kao S.T. Wu D.C. Luteolin inhibits GABAA receptors in HEK cells and brain slices. Sci. Rep. 2016 6 1 27695 10.1038/srep27695 27292079
    [Google Scholar]
  147. Algazo M. Rahimi N. Gheshlaghi A.S. Involvement of NMDA receptor and nitric oxide pathway in the anticonvulsant effect of genistein in ovariectomized mice. J Iran Med Counc Iran Medical Council 2019 2 3 35 41
    [Google Scholar]
  148. Gheshlaghi A.S. Jafari M.R. Algazo M. Rahimi N. Alshaib H. Dehpour A.R. Genistein modulation of seizure: Involvement of estrogen and serotonin receptors. J. Nat. Med. 2017 71 3 537 544 10.1007/s11418‑017‑1088‑3 28439683
    [Google Scholar]
  149. Elsayed A.A. Menze E.T. Tadros M.G. Ibrahim B.M.M. Sabri N.A. Khalifa A.E. Retracted article: Effects of genistein on pentylenetetrazole-induced behavioral and neurochemical deficits in ovariectomized rats. Naunyn Schmiedebergs Arch. Pharmacol. 2018 391 1 27 36 10.1007/s00210‑017‑1435‑7 29067514
    [Google Scholar]
  150. Bahadir A. Demir S. Orallar H. Beyazcicek E. Cetinkaya A. Ankarali S. Ankarali H. Gender specificity of genistein treatment in penicillin-induced epileptiform activity in rats. Neurophysiology 2016 48 6 421 428 10.1007/s11062‑017‑9619‑9
    [Google Scholar]
  151. Guo J. Min D. Feng H.J. Genistein, a natural isoflavone, alleviates seizure-induced respiratory arrest in dba/1 mice. Front. Neurol. 2021 12 761912 10.3389/fneur.2021.761912 34803895
    [Google Scholar]
  152. Khatoon S. Agarwal N.B. Samim M. Alam O. Neuroprotective effect of fisetin through suppression of il-1r/tlr axis and apoptosis in pentylenetetrazole-induced kindling in mice. Front. Neurol. 2021 12 689069 10.3389/fneur.2021.689069 34354662
    [Google Scholar]
  153. Mahawar S. Rakshit D. Patel I. Gore S.K. Sen S. Ranjan O.P. Mishra A. Fisetin-loaded chitosan nanoparticles ameliorate pilocarpine-induced temporal lobe epilepsy and associated neurobehavioral alterations in mice: Role of ROS/TNF-α-NLRP3 inflammasomes pathway. Nanomedicine 2024 59 102752 10.1016/j.nano.2024.102752 38740358
    [Google Scholar]
  154. Mehta D.K. Das R. Yadav S. Sharma V. Gupta S. Goyal A. SARS CoV-2 Omicron (B. 1.1. 529) recent updates and challenges worldwide. Infect. Disord. Drug Targets 2023 23 5 e240323214950 10.2174/1871526523666230324113146 36967463
    [Google Scholar]
  155. Raygude K.S. Kandhare A.D. Ghosh P. Bodhankar S.L. Anticonvulsant effect of fisetin by modulation of endogenous biomarkers. Biomedicine & Preventive Nutrition 2012 2 3 215 222 10.1016/j.bionut.2012.04.005
    [Google Scholar]
  156. Zhai K. Hu L. Chen J. Fu C. Chen Q. Chrysin induces hyperalgesia via the GABAA receptor in mice. Planta Med. 2008 74 10 1229 1234 10.1055/s‑2008‑1081288 18612941
    [Google Scholar]
  157. Zhang Y. Zhao J. Afzal O. Kazmi I. Abbasi A.F.A. Altamimi A.S.A. Yang Z. Neuroprotective role of chrysin‐loaded poly(lactic‐co‐glycolic acid) nanoparticle against kindling‐induced epilepsy through Nrf2/ARE/HO‐1 pathway. J. Biochem. Mol. Toxicol. 2021 35 2 e22634 10.1002/jbt.22634 32991785
    [Google Scholar]
  158. Abbasi E. Nassiri-Asl M. Shafeei M. Sheikhi M. Neuroprotective effects of vitexin, a flavonoid, on pentylenetetrazole-induced seizure in rats. Chem. Biol. Drug Des. 2012 80 2 274 278 10.1111/j.1747‑0285.2012.01400.x 22554436
    [Google Scholar]
  159. Oliveira d.D.D. Silva d.C.P. Iglesias B.B. Beleboni R.O. Vitexin Possesses Anticonvulsant and Anxiolytic-Like Effects in Murine Animal Models. Front. Pharmacol. 2020 11 1181 10.3389/fphar.2020.01181 32848784
    [Google Scholar]
  160. Luo W. Min J. Huang W.X. Wang X. Peng Y. Han S. Yin J. Liu W.H. He X.H. Peng B.W. Vitexin reduces epilepsy after hypoxic ischemia in the neonatal brain via inhibition of NKCC1. J. Neuroinflammation 2018 15 1 186 10.1186/s12974‑018‑1221‑6 29925377
    [Google Scholar]
  161. Eken H. Turkmen B.N. Senel B. Arslan R. Examination of the effects of vitexin and vitexin-loaded solid lipid nanoparticles on neuropathic pain and possible mechanisms of action. Neuropharmacology 2024 253 109961 10.1016/j.neuropharm.2024.109961 38657947
    [Google Scholar]
  162. Golechha M. Chaudhry U. Bhatia J. Saluja D. Arya D.S. Naringin protects against kainic acid-induced status epilepticus in rats: Evidence for an antioxidant, anti-inflammatory and neuroprotective intervention. Biol. Pharm. Bull. 2011 34 3 360 365 10.1248/bpb.34.360 21372385
    [Google Scholar]
  163. Jeong K.H. Jung U.J. Kim S.R. Naringin attenuates autophagic stress and neuroinflammation in kainic acid-treated hippocampus in vivo. Evid. Based Complement. Alternat. Med. 2015 2015 1 9 10.1155/2015/354326 26124853
    [Google Scholar]
  164. Park J. Jeong K.H. Shin W.H. Bae Y.S. Jung U.J. Kim S.R. Naringenin ameliorates kainic acid-induced morphological alterations in the dentate gyrus in a mouse model of temporal lobe epilepsy. Neuroreport 2016 27 15 1182 1189 10.1097/WNR.0000000000000678 27584687
    [Google Scholar]
  165. Bharti S. Rani N. Krishnamurthy B. Arya D. Preclinical evidence for the pharmacological actions of naringin: A review. Planta Med. 2014 80 6 437 451 10.1055/s‑0034‑1368351 24710903
    [Google Scholar]
  166. Fu P. Yuan Q. Sun Y. Wu X. Du Z. Li Z. Yu J. Lv K. Hu J. Baicalein ameliorates epilepsy symptoms in a pilocarpine-induced rat model by regulation of igf1r. Neurochem. Res. 2020 45 12 3021 3033 10.1007/s11064‑020‑03150‑8 33095440
    [Google Scholar]
  167. Li P. Wang X. Zhang J. Baicalein administration protects against pentylenetetrazole-induced chronic epilepsy in rats. Trop. J. Pharm. Res. 2018 17 2 293 10.4314/tjpr.v17i2.14
    [Google Scholar]
  168. Qian X. Wang Z.R. Zheng J.J. Ding J.Q. Zhong J.G. Zhang T.Y. Li W. Zhang M. Baicalein improves cognitive deficits and hippocampus impairments in temporal lobe epilepsy rats. Brain Res. 2019 1714 111 118 10.1016/j.brainres.2019.02.028 30817901
    [Google Scholar]
  169. Anjali P.B. Jawahar N. Kumar P.M.R. Jubie S. Selvamuthukumar S. Nanocarriers in the treatment of epilepsy: Challenges and opportunities. J. Drug Deliv. Sci. Technol. 2024 97 105788 10.1016/j.jddst.2024.105788
    [Google Scholar]
  170. Heidarieh N. Nikzad H. Jamshidi-Arani T. Effect of green tea catechins on PTZ-induced seizure in male mice. 2013 Available from: https://openurl.ebsco.com/contentitem/gcd:90292145?sid=ebsco:plink:crawler&id=ebsco:gcd:90292145
  171. Koshal P. Jamwal S. Akula K.K. Animal Models of Epilepsy. Animal Models of Neurological Disorders Springer Singapore. Bansal P.K. Deshmukh R. Singapore Springer Nature Singapore 2017 59 78 10.1007/978‑981‑10‑5981‑0_5
    [Google Scholar]
  172. Ghayur M.N. Khan H. Gilani A.H. Antispasmodic, bronchodilator and vasodilator activities of (+)-catechin, a naturally occurring flavonoid. Arch. Pharm. Res. 2007 30 8 970 975 10.1007/BF02993965 17879750
    [Google Scholar]
  173. Altun A. Evaluation of Hexarelin Effects on Epileptic Seizures, Hippocampal Neuronal Damage and Memory Impairment after Pentylenetetrazole-Induced Acute Model in Rat. American Journal of Biomedical Science & Research 2019 5 4 329 333 10.34297/AJBSR.2019.05.000938
    [Google Scholar]
  174. Kumar S. Ivanov S. Lagunin A. Goel R.K. Bioinformatics guided rotenone adjuvant kindling in mice as a new animal model of drug-resistant epilepsy. Comput. Biol. Med. 2022 147 105754 10.1016/j.compbiomed.2022.105754 35753090
    [Google Scholar]
  175. Aycik F.B. Ayyildiz M. Agar E. Role of cannabinoid CB1 receptors in the proconvulsant effect of Apelin-13 on penicillin-induced epileptiform activity. Indian J Exp Biol IJEB 2024 62 04 238 244
    [Google Scholar]
  176. Baradaran S. Ghasemi-Kasman M. Ebrahimpour A. Anticonvulsant effects of hesperetin in animal model of pentylenetetrazole-induced-seizures. J Babol Univ Med Sci Journal of Babol University of Medical Sciences 2018 20 11 19 26
    [Google Scholar]
  177. Kwon J.Y. Jung U.J. Kim D.W. Kim S. Moon G.J. Hong J. Jeon M.T. Shin M. Chang J.H. Kim S.R. Beneficial effects of hesperetin in a mouse model of temporal lobe epilepsy. J. Med. Food 2018 21 12 1306 1309 10.1089/jmf.2018.4183 30136878
    [Google Scholar]
  178. Sharma P. Kumari S. Sharma J. Purohit R. Singh D. Hesperidin interacts with CREB-BDNF signaling pathway to suppress pentylenetetrazole-induced convulsions in zebrafish. Front. Pharmacol. 2021 11 607797 10.3389/fphar.2020.607797 33505312
    [Google Scholar]
  179. Kumar A. Lalitha S. Mishra J. Hesperidin potentiates the neuroprotective effects of diazepam and gabapentin against pentylenetetrazole-induced convulsions in mice: Possible behavioral, biochemical and mitochondrial alterations. Indian J. Pharmacol. 2014 46 3 309 315 10.4103/0253‑7613.132180 24987179
    [Google Scholar]
  180. Liu Z. Tu K. Zou P. Liao C. Ding R. Huang Z. Huang Z. Yao X. Chen J. Zhang Z. Hesperetin ameliorates spinal cord injury by inhibiting NLRP3 inflammasome activation and pyroptosis through enhancing Nrf2 signaling. Int. Immunopharmacol. 2023 118 110103 10.1016/j.intimp.2023.110103 37001385
    [Google Scholar]
  181. Singh D. Cellular and molecular interactions of dietary flavonoids toward seizures suppression in epilepsy. Treatments, Nutraceuticals, Supplements, and Herbal Medicine in Neurological Disorders New York Elsevier 2023 305 325 10.1016/B978‑0‑323‑90052‑2.00030‑5
    [Google Scholar]
  182. Qu Z. Jia L. Xie T. Zhen J. Si P. Cui Z. Xue Y. Sun C. Wang W. (–)-Epigallocatechin-3-gallate protects against lithium-pilocarpine-induced epilepsy by inhibiting the toll-like receptor 4 (TLR4)/Nuclear factor-κb (nf-κb) signaling pathway. Med. Sci. Monit. 2019 25 1749 1758 10.12659/MSM.915025 30843525
    [Google Scholar]
  183. Sun Z.Q. Meng F.H. Tu L.X. Sun L. Myricetin attenuates the severity of seizures and neuroapoptosis in pentylenetetrazole kindled mice by regulating the of BDNF‑TrkB signaling pathway and modulating matrix metalloproteinase‑9 and GABAA. Exp. Ther. Med. 2019 17 4 3083 3091 10.3892/etm.2019.7282 30906480
    [Google Scholar]
  184. Zhang X.H. Ma Z.G. Rowlands D.K. Flavonoid myricetin modulates G A B A A receptor activity through activation of ca 2 + channels and camk-ii pathway. Evid. Based Complement. Alternat. Med. 2012 2012 1 10
    [Google Scholar]
  185. Sethiya N.K. Ghiloria N. Srivastav A. Bisht D. Chaudhary S.K. Walia V. Alam M.S. Therapeutic potential of myricetin in the treatment of neurological, neuropsychiatric, and neurodegenerative disorders. CNS Neurol. Disord. Drug Targets 2024 23 7 865 882 10.2174/1871527322666230718105358 37461364
    [Google Scholar]
  186. Guo X. Cao Y. Hao F. Yan Z. Wang M. Liu X. Tangeretin alters neuronal apoptosis and ameliorates the severity of seizures in experimental epilepsy-induced rats by modulating apoptotic protein expressions, regulating matrix metalloproteinases, and activating the PI3K/Akt cell survival pathway. Adv. Med. Sci. 2017 62 2 246 253 10.1016/j.advms.2016.11.011 28501723
    [Google Scholar]
  187. Jadhav A.D. Jadhav R.R. Padwal S.L. Jadhav S.S. Kale A.S. Gade P.R. Evaluation of anticonvulsant activity of angiotensin receptor antagonists in an animal model. Int. J. Basic Clin. Pharmacol. 2020 10 1 29 10.18203/2319‑2003.ijbcp20205534
    [Google Scholar]
  188. Jamali-Raeufy N. Baluchnejadmojarad T. Roghani M. keimasi S. goudarzi M. Isorhamnetin exerts neuroprotective effects in STZ-induced diabetic rats via attenuation of oxidative stress, inflammation and apoptosis. J. Chem. Neuroanat. 2019 102 101709 10.1016/j.jchemneu.2019.101709 31698018
    [Google Scholar]
  189. Alqudah A. Qnais E.Y. Wedyan M.A. Altaber S. Bseiso Y. Oqal M. AbuDalo R. Alrosan K. Alrosan A.Z. Melhim B.S. Alqudah M. Athamneh R.Y. Gammouh O. Isorhamnetin reduces glucose level, inflammation, and oxidative stress in high-fat diet/streptozotocin diabetic mice model. Molecules 2023 28 2 502 10.3390/molecules28020502 36677559
    [Google Scholar]
  190. Li Y. Chi G. Shen B. Tian Y. Feng H. Isorhamnetin ameliorates LPS-induced inflammatory response through downregulation of NF-κB signaling. Inflammation 2016 39 4 1291 1301 10.1007/s10753‑016‑0361‑z 27138362
    [Google Scholar]
  191. Edwards S.E. Rocha C.d.I. Williamson E.M. Phytopharmacy: An evidence-based guide to herbal medicinal products. New York John Wiley & Sons 2015 10.1002/9781118543436
    [Google Scholar]
  192. Aonuma K Xu D Murakoshi N Impact of isorhamnetin for suppression of action potential aberrations associated with atrial fibrillation. Europ. Heart J. 2023 44 Supplement_2 ehad655 3175 10.1093/eurheartj/ehad655.3175
    [Google Scholar]
  193. Zhao J.J. Song J.Q. Pan S.Y. Wang K. Treatment with isorhamnetin protects the brain against ischemic injury in mice. Neurochem. Res. 2016 41 8 1939 1948 10.1007/s11064‑016‑1904‑2 27161367
    [Google Scholar]
  194. Qi H. Liu L. Rhoifolin attenuates damage to hippocampal neuronal culture model of acquired epilepsy in vitro by regulating NF-κB/iNOS/COX-2 axis. Qual. Assur. Saf. Crops Foods 2022 14 3 116 123 10.15586/qas.v14i3.1093
    [Google Scholar]
  195. Ratnoglik S.L. Aoki C. Sudarmono P. Komoto M. Deng L. Shoji I. Fuchino H. Kawahara N. Hotta H. Antiviral activity of extracts from Morinda citrifolia leaves and chlorophyll catabolites, pheophorbide a and pyropheophorbide a, against hepatitis C virus. Microbiol. Immunol. 2014 58 3 188 194 10.1111/1348‑0421.12133 24438164
    [Google Scholar]
  196. Dedeurwaerdere S. Neuromodulation in Experimetal Animal Models of Epilepsy. (Doctoral dissertation Ghent University). 2005
    [Google Scholar]
  197. Zhuang J. Peng Y. Gu C. Chen H. Lin Z. Zhou H. Wu X. Li J. Yu X. Cao Y. Zeng H. Fu X. Xu C. Huang P. Cao S. Wang C. Yan F. Chen G. Wogonin accelerates hematoma clearance and improves neurological outcome via the ppar-γ pathway after intracerebral hemorrhage. Transl. Stroke Res. 2021 12 4 660 675 10.1007/s12975‑020‑00842‑9 32918259
    [Google Scholar]
  198. Aspatwar A Nath R Bhowmik R Nanoparticles of herbal extracts in treatment of neurodegenerative disorders. ChemRxiv 2024 8 238
    [Google Scholar]
  199. Fernandes F. Dias-Teixeira M. Delerue-Matos C. Grosso C. Critical review of lipid-based nanoparticles as carriers of neuroprotective drugs and extracts. Nanomaterials 2021 11 3 563 10.3390/nano11030563 33668341
    [Google Scholar]
  200. Ahmad N. Ahmad R. Alrasheed R. Almatar H. Ramadan A.A. Amir M. Sarafroz M. Quantification and evaluations of catechin hydrate polymeric nanoparticles used in brain targeting for the treatment of epilepsy. Pharmaceutics 2020 12 3 203 10.3390/pharmaceutics12030203 32120778
    [Google Scholar]
  201. George M.Y. Derany E.M.O. Ahmed Y. Zaher M. Ibrahim C. Waleed H. Khaled H. Khaled G. Saleh A. Alshafei H. Alshafei R. Ahmed N. Ezz S. Ashraf N. Ibrahim S.S. Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polarization, and AMPK/SIRT-1/PGC-1α pathway. Expert Opin. Drug Deliv. 2023 20 1 159 174 10.1080/17425247.2023.2153831 36446395
    [Google Scholar]
  202. Rehman M.U. Tariq L. Arafah A. Ali S. Beigh S. Dar M.A. Dar T.H. Dar A.I. Alsaffar R.M. Masoodi M.H. Nanogel-based transdermal drug delivery system: A therapeutic strategy with under discussed potential. Curr. Top. Med. Chem. 2023 23 1 44 61 10.2174/1568026622666220818112728 35984019
    [Google Scholar]
  203. Bhattacharya T. Soares G.A.B. Chopra H. Rahman M.M. Hasan Z. Swain S.S. Cavalu S. Applications of phyto-nanotechnology for the treatment of neurodegenerative disorders. Materials 2022 15 3 804 10.3390/ma15030804 35160749
    [Google Scholar]
  204. Jana K. Ghosh S. Debnath B. Rout C.S. Sarangi K.M. Halder J. Rajwar K.T. Pradhan D. Rai K.V. Dash P. Das C. Kar B. Ghosh G. Rath G. Recent advancements of hyaluronic acid nanoscaffolds in arthritis management. ChemistrySelect 2024 9 32 e202402035 10.1002/slct.202402035
    [Google Scholar]
  205. Elkomy M.H. Zaki R.M. Alsaidan O.A. Elmowafy M. Zafar A. Shalaby K. Abdelgawad M.A. Abo El-Ela F.I. Rateb M.E. Naguib I.A. Eid H.M. Intranasal nanotransferosomal gel for quercetin brain targeting: I. optimization, characterization, brain localization, and cytotoxic studies. Pharmaceutics 2023 15 7 1805 10.3390/pharmaceutics15071805 37513991
    [Google Scholar]
  206. Cano A. Ettcheto M. Espina M. Auladell C. Calpena A.C. Folch J. Barenys M. Sánchez-López E. Camins A. García M.L. Epigallocatechin-3-gallate loaded PEGylated-PLGA nanoparticles: A new anti-seizure strategy for temporal lobe epilepsy. Nanomedicine 2018 14 4 1073 1085 10.1016/j.nano.2018.01.019 29454994
    [Google Scholar]
  207. Missiry E.M.A. Othman A.I. Amer M.A. Sedki M. Ali S.M. Sherbiny E.I.M. Nanoformulated ellagic acid ameliorates pentylenetetrazol-induced experimental epileptic seizures by modulating oxidative stress, inflammatory cytokines and apoptosis in the brains of male mice. Metab. Brain Dis. 2020 35 2 385 399 10.1007/s11011‑019‑00502‑4 31728888
    [Google Scholar]
  208. Gupta I. Adin S.N. Aqil M. Mujeeb M. Nose to brain delivery of naringin loaded transniosomes for epilepsy: Formulation, characterisation, blood-brain distribution and invivo pharmacodynamic evaluation. J. Liposome Res. 2024 34 1 60 76 10.1080/08982104.2023.2214619 37212622
    [Google Scholar]
  209. Ghosh A. Khanam N. Nath D. Solid lipid nanoparticle: A potent vehicle of the kaempferol for brain delivery through the blood-brain barrier in the focal cerebral ischemic rat. Chem. Biol. Interact. 2024 397 111084 10.1016/j.cbi.2024.111084 38823537
    [Google Scholar]
  210. Alrashdi B.M. Fehaid A. Kassab R.B. Rizk S. Habotta O.A. Moneim A.A.E. Biosynthesized selenium nanoparticles using epigallocatechin gallate protect against pentylenetetrazole-induced acute epileptic seizures in mice via antioxidative, anti-inflammatory, and anti-apoptotic activities. Biomedicines 2023 11 7 1955 10.3390/biomedicines11071955 37509594
    [Google Scholar]
  211. Canbolat F. Demir N. Yayıntas O.T. Pehlivan M. Eldem A. Ayna T.K. Senel M. Chitosan nanoparticles loaded with quercetin and valproic acid: A novel approach for enhancing antioxidant activity against oxidative stress in the sh-sy5y human neuroblastoma cell line. Biomedicines 2024 12 2 287 10.3390/biomedicines12020287 38397889
    [Google Scholar]
  212. Puri V. Kanojia N. Sharma A. Huanbutta K. Dheer D. Sangnim T. Natural product-based pharmacological studies for neurological disorders. Front. Pharmacol. 2022 13 1011740 10.3389/fphar.2022.1011740 36419628
    [Google Scholar]
  213. Sharifi-Rad J. Quispe C. Herrera-Bravo J. Martorell M. Sharopov F. Tumer T.B. Kurt B. Lankatillake C. Docea A.O. Moreira A.C. Dias D.A. Mahomoodally M.F. Lobine D. Cruz-Martins N. Kumar M. Calina D. A pharmacological perspective on plant-derived bioactive molecules for epilepsy. Neurochem. Res. 2021 46 9 2205 2225 10.1007/s11064‑021‑03376‑0 34120291
    [Google Scholar]
  214. Chopra B. Dhingra A.K. Kapoor R.P. Prasad D.N. Piperine and its various physicochemical and biological aspects: A review. Open Chem. J. 2016 3 1 75 96 10.2174/1874842201603010075
    [Google Scholar]
  215. Asgarshirazi M. Shariat M. Sheikh M. Comparison of efficacy of folic acid and silymarin in the management of antiepileptic drug induced liver injury: A randomized clinical trial. Hepatobiliary Pancreat. Dis. Int. 2017 16 3 296 302 10.1016/S1499‑3872(16)60142‑X 28603098
    [Google Scholar]
  216. Levin J. Maaß S. Schuberth M. Giese A. Oertel W.H. Poewe W. Trenkwalder C. Wenning G.K. Mansmann U. Südmeyer M. Eggert K. Mollenhauer B. Lipp A. Löhle M. Classen J. Münchau A. Kassubek J. Gandor F. Berg D. Egert-Schwender S. Eberhardt C. Paul F. Bötzel K. Ertl-Wagner B. Huppertz H.J. Ricard I. Höglinger G.U. André E. Blankenstein C. Canelo M. Düring M. Ebentheuer J. Fricke C. Gerbes A. Groiss S. Gruber D. Hartmann C. Kirchner T. Kroneberg D. Kunz M. Lorenzl S. Moldovan A. Noda A. Pape H. Respondek G. Schäffer E. Schneider M. Schnitzler A. Schulz-Schaeffer W. Schwarz J. Skowronek C. Storch A. Tadic V. Vadász D. Zimmermann B. PROMESA Study Group Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA): A randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2019 18 8 724 735 10.1016/S1474‑4422(19)30141‑3 31278067
    [Google Scholar]
  217. Elkommos S. Mula M. Current and future pharmacotherapy options for drug-resistant epilepsy. Expert Opin. Pharmacother. 2022 23 18 2023 2034 10.1080/14656566.2022.2128670 36154780
    [Google Scholar]
  218. David B. Wolfender J.L. Dias D.A. The pharmaceutical industry and natural products: Historical status and new trends. Phytochem. Rev. 2015 14 2 299 315 10.1007/s11101‑014‑9367‑z
    [Google Scholar]
  219. Mahima K. Kumar S.K.N. Rakhesh K.V. Rajeswaran P.S. Sharma A. Sathishkumar R. Advancements and future prospective of DNA barcodes in the herbal drug industry. Front. Pharmacol. 2022 13 947512 10.3389/fphar.2022.947512 36339543
    [Google Scholar]
  220. Nabavi S.F. Braidy N. Gortzi O. Sobarzo-Sanchez E. Daglia M. Skalicka-Woźniak K. Nabavi S.M. Luteolin as an anti-inflammatory and neuroprotective agent: A brief review. Brain Res. Bull. 2015 119 Pt A 1 11 10.1016/j.brainresbull.2015.09.002 26361743
    [Google Scholar]
  221. Dere D.M. Khan A.A. Potentials of encapsulated flavonoids in biologics: A review. American Journal of Biomedical and Life Sciences 2020 8 4 97 10.11648/j.ajbls.20200804.16
    [Google Scholar]
  222. Paczkowska M. McDonagh A.F. Bialek K. Tajber L. Cielecka-Piontek J. Mechanochemical activation with cyclodextrins followed by compaction as an effective approach to improving dissolution of rutin. Int. J. Pharm. 2020 581 119294 10.1016/j.ijpharm.2020.119294 32247814
    [Google Scholar]
  223. Shelygin Y. Krivokapic Z. Frolov S.A. Kostarev I.V. Astashov V.L. Vasiliev S.V. Lakhin A.V. Rodoman G.V. Soloviev A.O. Stoyko Y.M. Khitaryan A.G. Nechay I.A. Clinical acceptability study of micronized purified flavonoid fraction 1000 mg tablets versus 500 mg tablets in patients suffering acute hemorrhoidal disease. Curr. Med. Res. Opin. 2016 32 11 1821 1826 10.1080/03007995.2016.1211520 27404053
    [Google Scholar]
  224. Petersen B. Egert S. Bosy-Westphal A. Müller M.J. Wolffram S. Hubbermann E.M. Rimbach G. Schwarz K. Bioavailability of quercetin in humans and the influence of food matrix comparing quercetin capsules and different apple sources. Food Res. Int. 2016 88 Pt A 159 165 10.1016/j.foodres.2016.02.013 28847395
    [Google Scholar]
  225. Taliou A. Zintzaras E. Lykouras L. Francis K. An open-label pilot study of a formulation containing the anti-inflammatory flavonoid luteolin and its effects on behavior in children with autism spectrum disorders. Clin. Ther. 2013 35 5 592 602 10.1016/j.clinthera.2013.04.006 23688534
    [Google Scholar]
  226. Gokhale J.P. Mahajan H.S. Surana S.J. Quercetin loaded nanoemulsion-based gel for rheumatoid arthritis: In vivo and in vitro studies. Biomed. Pharmacother. 2019 112 108622 10.1016/j.biopha.2019.108622 30797146
    [Google Scholar]
  227. Sguizzato M. Valacchi G. Pecorelli A. Boldrini P. Simelière F. Huang N. Cortesi R. Esposito E. Gallic acid loaded poloxamer gel as new adjuvant strategy for melanoma: A preliminary study. Colloids Surf. B Biointerfaces 2020 185 110613 10.1016/j.colsurfb.2019.110613 31715454
    [Google Scholar]
  228. Rabidas S.S. Prakash C. Tyagi J. Suryavanshi J. Kumar P. Bhattacharya J. Sharma D. A comprehensive review on anti-inflammatory response of flavonoids in experimentally-induced epileptic seizures. Brain Sci. 2023 13 1 102 10.3390/brainsci13010102 36672083
    [Google Scholar]
  229. Chen P. Chen F. Guo Z. Lei J. Zhou B. Recent advancement in bioeffect, metabolism, stability, and delivery systems of apigenin, a natural flavonoid compound: Challenges and perspectives. Front. Nutr. 2023 10 1221227 10.3389/fnut.2023.1221227 37565039
    [Google Scholar]
  230. Shivani S.G. Singh G. Narwal S. Balram Chopra B. Dhingra A.K. Nano-formulations for the management of epilepsy: Synthetic and herbal drug perspectives. Curr. Nanomed. 2024 15 15 10.2174/0124681873302617241018085244
    [Google Scholar]
  231. Ferreira M.D. Duarte J. Veiga F. Paiva-Santos A.C. Pires P.C. Nanosystems for brain targeting of antipsychotic drugs: An update on the most promising nanocarriers for increased bioavailability and therapeutic efficacy. Pharmaceutics 2023 15 2 678 10.3390/pharmaceutics15020678 36840000
    [Google Scholar]
  232. Mokhtari T. Sheikhbahaei F. Saadat M. Nose-to-Brain Delivery of Nanoformulations for Treatment of Depression: Focus on Antioxidant and Anti-Inflammatory Pathways. Erisen D.E. Uludag K. Ahmad N. New York Advances in Medical Diagnosis, Treatment, and Care IGI Global 2024 245 274
    [Google Scholar]
  233. Smoliga J.M. Vang O. Baur J.A. Challenges of translating basic research into therapeutics: Resveratrol as an example. J. Gerontol. A Biol. Sci. Med. Sci. 2012 67A 2 158 167 10.1093/gerona/glr062 21746739
    [Google Scholar]
  234. Melrose J. The potential of flavonoids and flavonoid metabolites in the treatment of neurodegenerative pathology in disorders of cognitive decline. Antioxidants 2023 12 3 663 10.3390/antiox12030663 36978911
    [Google Scholar]
  235. Bishnoi S. Herbs as Functional Foods. Functional Foods. Bara Boca Sources and Health Benefits Scientific Publishers 2016 141 172
    [Google Scholar]
  236. Hu M. Wu B. Liu Z. Bioavailability of polyphenols and flavonoids in the era of precision medicine. Mol. Pharm. 2017 14 9 2861 2863 10.1021/acs.molpharmaceut.7b00545 28870081
    [Google Scholar]
  237. Wu C.T. Chen M.C. Liu S.H. Yang T.H. Long L.H. Guan S.S. Chen C.M. Bioactive flavonoids icaritin and icariin protect against cerebral ischemia–reperfusion-associated apoptosis and extracellular matrix accumulation in an ischemic stroke mouse model. Biomedicines 2021 9 11 1719 10.3390/biomedicines9111719 34829948
    [Google Scholar]
  238. Speisky H. Shahidi F. Costa de Camargo A. Fuentes J. Revisiting the oxidation of flavonoids: Loss, conservation or enhancement of their antioxidant properties. Antioxidants 2022 11 1 133 10.3390/antiox11010133 35052636
    [Google Scholar]
  239. Behera P.C. Senapati M.R. Oxidative stress and its management through phytoconstituents. Recent frontiers of phytochemicals New York Elsevier 2023 483 499 10.1016/B978‑0‑443‑19143‑5.00014‑1
    [Google Scholar]
  240. Zhang X. Wu C. In silico, in vitro, and in vivo evaluation of the developmental toxicity, estrogenic activity, and mutagenicity of four natural phenolic flavonoids at low exposure levels. ACS Omega 2022 7 6 4757 4768 10.1021/acsomega.1c04239 35187296
    [Google Scholar]
  241. Hasan S. Khatri N. Rahman Z.N. Menezes A.A. Martini J. Shehjar F. Mujeeb N. Shah Z.A. Neuroprotective potential of flavonoids in brain disorders. Brain Sci. 2023 13 9 1258 10.3390/brainsci13091258 37759859
    [Google Scholar]
  242. Bjørklund G. Antonyak H. Polishchuk A. Semenova Y. Lesiv M. Lysiuk R. Peana M. Effect of methylmercury on fetal neurobehavioral development: An overview of the possible mechanisms of toxicity and the neuroprotective effect of phytochemicals. Arch. Toxicol. 2022 96 12 3175 3199 10.1007/s00204‑022‑03366‑3 36063174
    [Google Scholar]
  243. White D.L. Kanwal F. Jiao L. Epidemiology of Hepatocellular Carcinoma. Hepatocellular Carcinoma Springer International Publishing. Carr B.I. Cham Springer 2016 3 24 10.1007/978‑3‑319‑34214‑6_1
    [Google Scholar]
  244. Asgharian P. Quispe C. Herrera-Bravo J. Sabernavaei M. Hosseini K. Forouhandeh H. Ebrahimi T. Sharafi-Badr P. Tarhriz V. Soofiyani S.R. Helon P. Rajkovic J. Daştan D.S. Docea A.O. Sharifi-Rad J. Calina D. Koch W. Cho W.C. Pharmacological effects and therapeutic potential of natural compounds in neuropsychiatric disorders: An update. Front. Pharmacol. 2022 13 926607 10.3389/fphar.2022.926607 36188551
    [Google Scholar]
  245. Löscher W. Klein P. New approaches for developing multi-targeted drug combinations for disease modification of complex brain disorders. Does epilepsy prevention become a realistic goal? Pharmacol. Ther. 2022 229 107934 10.1016/j.pharmthera.2021.107934 34216705
    [Google Scholar]
  246. Dajas F Andres J.A-C Florencia A Neuroprotective actions of flavones and flavonols: Mechanisms and relationship to flavonoid structural features. Cent. Nerv. Syst. Agents Med. Chem. 2013 13 1 30 35
    [Google Scholar]
  247. Street J.S. Qiu Y. Lignani G. Are genetic therapies for epilepsy ready for the clinic? Epilepsy Curr. 2023 23 4 245 250 10.1177/15357597231176234 37662470
    [Google Scholar]
  248. Maan G. Sikdar B. Kumar A. Shukla R. Mishra A. Role of flavonoids in neurodegenerative diseases: Limitations and future perspectives. Curr. Top. Med. Chem. 2020 20 13 1169 1194 10.2174/1568026620666200416085330 32297582
    [Google Scholar]
  249. Barker-Haliski M. DePaula-Silva A.B. Pitsch J. Sontheimer H. Hirsch L.J. Galanopoulou A.S. Kearney J.A. Brain on Fire: How brain infection and neuroinflammation drive worldwide epilepsy burden. Epilepsy Curr. 2024 ••• 15357597241242238 10.1177/15357597241242238 39554268
    [Google Scholar]
  250. Costa B. Vale N. Virus-induced epilepsy vs. epilepsy patients acquiring viral infection: Unravelling the complex relationship for precision treatment. Int. J. Mol. Sci. 2024 25 7 3730 10.3390/ijms25073730 38612542
    [Google Scholar]
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Recent Advances in Bioactive Flavonoids-based Nanotherapeutics as Promising Neuroprotectants in Epilepsy
Bentham Science Publishers ; https://doi.org/10.2174/0118746098369369250119112935
/content/journals/cas/10.2174/0118746098369369250119112935
/content/journals/cas/10.2174/0118746098369369250119112935
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  • Article Type:     Review Article
Keywords: epilepsy ; nanoformulations ; Neuroprotective ; flavonoids ; seizure ; clinical status

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