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image of Variability in Exercise is Linked to Improved Age-related Dysfunctions, Suggesting a Potential Role for the Constrained-Disorder Principle-based Second-Generation Artificial Intelligence System

Abstract

Objective

Regular physical activity (PA) promotes mental and physical health. Nevertheless, inactivity is a worldwide pandemic, and methods to augment exercise benefits are required. The constrained disorder principle (CDP) characterizes biological systems based on their inherent variability. Therefore, we aimed to investigate the association between intra-individual variability in PA and disability among non-athlete adults.

Methods

In this retrospective analysis of the longitudinal SHARE survey, we included non-disabled adults aged >50 with at least six visits over 14 years. Self-reported PA frequency was documented bi- to triennially. intensity was defined as vigorous PA frequency less than once a week. was described as an unchanged PA intensity in all consecutive middle observations. The primary outcome was defined as a physical limitation in everyday activities at the end of the survey. Secondary outcomes were cognitive functions, including short-term memory, long-term memory, and verbal fluency.

Results

The study included 2,049 non-disabled adults with a mean age of 53 and 49.1% women. In the initially intensity group, variability in PA was associated with increased physical disability prevalence (23.3% 33.2%, ; P<0.01; adjusted P<0.01). In the initially intensity group, variability was associated with a reduced physical disability (45.6% 33.3%, ; P=0.02; adjusted P=0.03). There were no statistically significant differences in cognitive parameters between the groups. Among individuals with the same low PA intensity at the beginning and end of follow-up, variability was associated with reduced physical disability (56.9% 36.5%, ; P=0.02; adjusted P=0.04) and improved short-term memory (score change: -0.28 +0.29, ; P=0.05).

Conclusion

Incorporating variability into PA regimens of inactive adults may enhance their physical and cognitive benefits.

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2024-01-20
2025-03-30

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/content/journals/cas/10.2174/0118746098339043241219060015
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Variability in Exercise is Linked to Improved Age-related Dysfunctions, Suggesting a Potential Role for the Constrained-Disorder Principle-based Second-Generation Artificial Intelligence System
Bentham Science Publishers ; https://doi.org/10.2174/0118746098339043241219060015
/content/journals/cas/10.2174/0118746098339043241219060015
/content/journals/cas/10.2174/0118746098339043241219060015
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  • Article Type:     Research Article
Keywords: variability ; complex systems ; defective engineering ; disorder ; artificial intelligence ; Aging

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