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Targeted Therapy of Tumors and Cancer Stem Cells based on Oxidant-regulated Redox Pathway and its Mechanism
Authors: Shunshun Wang, Juanjuan Han, Zijun Wang, Xianqiong Liu, Chunli Wang, Muhammad Farrukh Nisar, Lianhong Pan and Kang XuAvailable online: 30 May 2024More LessA malignant tumor is a frequent and common disease that severely threatens human health. Many mechanisms, such as cell signaling pathway, anti-apoptosis mechanism, cell stemness, metabolism, and cell phenotype, have been studied to explain the reasons for chemotherapy, radioresistance, and tumor recurrences in antitumor treatment. Cancer stem cells (CSCs) are important tumor cell subclasses that can Read More
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Mechanism of Shenfu Injection in Treating Ischemic Stroke Elucidated using Network Pharmacology and Experimental Validation
Authors: Xuecheng Yu, Kun Shi, Bin Wu, Zengxiang Gao, Jiyuan Tu, Yan Cao, Linlin Chen and Guosheng CaoAvailable online: 15 April 2024More LessBackground Shenfu injection was derived from the classical Chinese medicine formula ‘Shenfu decoction’, which was widely used in the treatment of cardiovascular and cerebrovascular diseases in clinical practice. Objectives Predict the main active ingredients, core targets, and related signaling pathways of Shenfu injection in the treatment of ischemic stroke. Methods Databases were used to collect the active ingredien Read More
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