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- Volume 29, Issue 3, 2022
Protein and Peptide Letters - Volume 29, Issue 3, 2022
Volume 29, Issue 3, 2022
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The 3-Oxoacyl-(Acyl-Carrier-Protein) Reductase HSD-X1 of Pseudomonas Citronellolis SJTE-3 Catalyzes the Conversion of 17β-estradiol to Estrone
Authors: Yali Fu, Wanli Peng, Shuangjun Lin, Zixin Deng and Rubing LiangBackground: Pseudomonas citronellolis SJTE-3 can efficiently degrade 17β-estradiol (E2) and other estrogenic chemicals. However, the enzyme responsible for E2 metabolism within strain SJTE-3 has remained unidentified. Objective: Here, a novel 3-oxoacyl-(acyl-carrier protein) (ACP) reductase, HSD-X1 (WP_ 009617962.1), was identified in SJTE-3 and its enzymatic characteristics for the transformation of E2 were inve Read More
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Aminoacyl-tRNA Synthetases, Indispensable Players in Lung Tumorigenesis
Authors: Pratyasha Bhowal, Priyanka B. Karmakar, Debkanya Dey, Riya Manna, Debraj Roy and Rajat BanerjeeBeing an essential enzyme in protein synthesis, the aminoacyl-tRNA synthetases (aaRSs) have a conserved function throughout evolution. However, research has uncovered altered expressions as well as interactions of aaRSs, in league with aaRS-interacting multi-functional proteins (AIMPs), forming a multi-tRNA synthetase complex (MSC) and divulging into their roles outside the range of protein synthesis. In this review, we h Read More
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Protein Arginine Methyltransferase 1 and its Dynamic Regulation Associated with Cellular Processes and Diseases
Authors: Hao Wu, Yichao Zhang, Shuo Liu, Dongwu Liu, Ao Li, Hongkuan Deng, Xiuzhen Zhang, Weiwei Wu, Baohua Liu and Qiuxiang PangPost-translational modifications (PTMs) of proteins influence protein degradation, protein- protein interactions, expression of genes, and intracellular signal transduction, thereby regulating major life processes. Among the PTMs occurring within the cytoplasm and nucleus, the most commonly studied one is the arginine methylation of proteins catalyzed by PRMTs. PRMT1 is the most excellent and extensively studied Read More
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The Sensitive Genes in Response to Various Metal Ion Stresses in the Yeast Saccharomyces cerevisiae
Authors: Keliang Lyu, Kailun Shi, Chengkun Liu, Zhiwen Lyu, Dongwu Liu and Xue WangYeast Saccharomyces cerevisiae is a good eukaryotic model for studying the molecular mechanism of toxic metal ion stress. Numerous studies have been performed on the signal transduction induced by toxic metal ion stress. The physiological process of eukaryotic cells has been studied, and various stress factors have been elucidated by constructing a gene deletion library. The sensitivity and tolerance mechanism of yea Read More
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Anticancer and Antimicrobial Evaluations on Alternative Reading Frame (ARF) Peptides and their Derivatives
Authors: Yuxin Wang, Kamal Patel, Zimei Wu and Vijayalekshmi SarojiniBackground: Alternative reading frame (ARF) protein up-regulates the intracellular level of a tumour suppressor protein, p53, by blocking MDM2 mediated p53 ubiquitination. The two homologous forms of ARF proteins are p19ARF in mice and p14ARF in humans. In our study, p19ARF-derived peptide ARF (26-44) and its cell-penetrating peptide conjugate Tat-ARF (26-44), p14ARF-derived peptide ARF (1-22), and its NrLS conjuga Read More
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Effect of Disease Causing Missense Mutations on Intrinsically Disordered Regions in Proteins
Authors: Suryanarayana Seera and Hampapathalu A. NagarajaramIntroduction: Disease causing missense mutations (DCMMs) destabilize protein structures. However it is not known how they impact the intrinsically disordered regions (IDRs) as these regions do not adopt stable 3D structures under physiological conditions. It is therefore imperative to investigate the effect of DCMMs on the functionally important IDRs. Objective: To investigate impact of DCMMs on functionally important IDRs in hu Read More
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Truncated Lactoferricin Peptide Controls Cervical Cancer Cell Proliferation via lncRNA-NKILA/NF-ΚB Feedback Loop
Authors: Yuan Pan, Yuting Jiang, Yingli Cui, Jihong Zhu and Yang YuBackground: Lactoferricin peptide (LP) has been reported to control cancer cell proliferation. NF-ΚB interacting lncRNA (NKILA) is a tumor suppressor in several cancers. Objective: We aimed to explore the potential function of the truncated LP (TLP) in the prevention of cervical cancer cell proliferation. Methods: Bioinformatics analysis via PPA-Pred2 showed that 18-aa N-terminus of truncated lactoferricin peptide (TLP1 Read More
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Volumes & issues
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Volume 32 (2025)
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Volume 31 (2024)
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Volume 30 (2023)
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Volume 29 (2022)
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Volume 28 (2021)
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Volume 27 (2020)
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Volume 26 (2019)
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Volume 25 (2018)
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Volume 24 (2017)
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Volume 23 (2016)
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Volume 22 (2015)
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Volume 21 (2014)
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Volume 20 (2013)
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Volume 19 (2012)
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Volume 18 (2011)
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Volume 17 (2010)
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Volume 16 (2009)
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Volume 15 (2008)
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Volume 14 (2007)
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Volume 13 (2006)
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Volume 12 (2005)
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Volume 11 (2004)
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Volume 10 (2003)
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Volume 9 (2002)
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Volume 8 (2001)
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