Protein and Peptide Letters - Volume 29, Issue 10, 2022

Ciliary neurotrophic factor (CNTF) is a pluripotent neurotrophic factor originally isolated from chicken embryo ciliary neurons. It has a powerful role in developing and maintaining the optic nervous system and has been used for many vision-related diseases. It also plays an important role in the neurogenesis, regeneration and survival of other neurons, including neural stem cells, dorsal root ganglion, sensory neurons and motor Read More

Background: Ovarian carcinoma (OC) is one of the most common malignancies of the female reproductive organs, with a low survival rate primarily due to the lack of effective methods for early diagnosis and prognosis. Objective: In this article, our motivation is to explore the lncRNA-related network mechanisms involved in the pathogenesis of OC. Methods: Public lncRNAs and mRNA expression datasets for OC were c Read More

Background: The ESKAPE group of pathogens which comprise of multidrug resistant bacteria, namely Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species are the cause of deadly nosocomial infections all over the world. While these pathogens have developed robust strategies to resist most antibiotics, their ability to form biofil Read More

Objective: This study aimed to evaluate the combination of SDF-1 and KLD-12 to form self-assembling polypeptide and its effect on osteogenic differentiation. Methods: ELISA assay was performed to detect whether KLD-12 composite SDF-1 self-assembled polypeptide was successfully prepared. BMSCs were isolated and characterized by Flow cytometry. MTT assays, Calcein-AM/PI fluorescence staining, and Glycosamino Read More

Background: Circular RNAs (circRNAs) exert an important regulatory effect on cancer progression. Reportedly, circRNAs can modulate gene expression by working as molecular sponges for miRNAs. Nonetheless, many functional circRNAs in hepatocellular carcinoma (HCC) remain to be identified. This study aimed to explore the role of hsa_circ_0006789 (circ_0006789) in HCC. Methods: The expression profile of circRNAs Read More

Background: Chitinases are plant defense-related proteins with a high biotechnological potential to be applied in agriculture. Objectives: This study aimed to purify a chitinase from the latex of Ficus benjamina. Methods: An antifungal class I chitinase, named FbLx-Chi-1, was purified from the latex of Ficus benjamina after precipitation with 30-60% ammonium sulfate and affinity chromatography on a chitin column and antifung Read More

Background: A growing body of evidence demonstrates that miR-137 acts against cancers; however, the biological function of miR-137 in esophageal squamous cell carcinoma (ESCC) remains to be fully understood. Objective: The aim of this study is to explore the role of miR-137 in ESCC. Methods: miR-137 expression was detected by reverse-transcription quantitative polymerase chain reaction (RT-qPCR), and target Read More

Background: Histone-like proteins are small molecular weight DNA-binding proteins that are widely distributed in prokaryotes. These proteins have multiple functions in cellular structures and processes, including the morphological stability of the nucleoid, DNA compactness, DNA replication, and DNA repair. Deinococcus radiodurans, an extremophilic microorganism, has extraordinary DNA repair capability and encodes an essenti Read More