Skip to content
2000
Volume 22, Issue 6
  • ISSN: 0929-8665
  • E-ISSN: 1875-5305

Abstract

PP2A is a serine/threonine phosphatase critical to a number of physiological and developmental processes. In this manuscript, we show that a peptide, specifically blocking the caspase- 9/PP2A interaction, DPT-C9h, induces apoptosis in primary tumour B cells isolated from peripheral blood mononuclear cells or bone marrow of chronic lymphocytic leukemia (CLL) patients, but not on B cells obtained from healthy donors (HD). Moreover, in both CLL patients and HD, DPT-C9h does not induce apoptosis on T- and NKcells and monocytes. Our results strongly suggest that DPT-C9h peptide has tumour specificity and that caspase-9/PP2Ac interaction constitutes a novel therapeutic approach for the treatment in CLL patients.

Loading

Article metrics loading...

/content/journals/ppl/10.2174/0929866522666150216115352
2015-06-01
2025-06-01
Loading full text...

Full text loading...

/content/journals/ppl/10.2174/0929866522666150216115352
Loading

  • Article Type:
    Research Article
Keyword(s): apoptosis; Caspase-9; CLL; penetrating peptides; PP2A
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test