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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Human Hsp70/Hsp90 Organizing Protein (Hop) D456G Is a Mixture of Monomeric and Dimeric Species
- Source: Protein and Peptide Letters, Volume 17, Issue 4, Apr 2010, p. 492 - 498
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- 01 May 2010
Abstract
Hop is a tetratricopeptide repeat domain (TPR)-containing co-chaperone that is able to directly associate with both Hsp70 and Hsp90. Previous data showed that the TPR2A-domain is the primary site for dimerization and that the TPR2B-domain may also play a role in dimerization. We present Hop-D456G, a mutant within the TPR2B-domain, that is a mixture of monomeric and dimeric species.
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