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2000
Volume 17, Issue 3
  • ISSN: 0929-8665
  • E-ISSN: 1875-5305

Abstract

Human cystathionine β-synthase (CBS) is a pyridoxal 5'-phosphate (PLP) dependent hemoprotein, which catalyzes the condensation of serine and homocysteine. Our mutagenesis studies suggest that Arg-266 is important to sense structural changes in heme-binding site, and that Gln-222 as well as Tyr-223 are involved in interactions with substrates.

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/content/journals/ppl/10.2174/092986610790780233
2010-03-01
2025-06-12
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/content/journals/ppl/10.2174/092986610790780233
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  • Article Type:
    Research Article
Keyword(s): Cystathionine; heme; hydrogen sulfide; pyridoxal 5'-phosphate
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