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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Molecular Modeling of Human BAD, a Pro-Apoptotic Bcl-2 Family Member, Integrating Glycolysis and Apoptosis
- Source: Protein and Peptide Letters, Volume 17, Issue 2, Feb 2010, p. 206 - 220
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- 01 Feb 2010
Abstract
Comparison between the BAD complexes indicated that BAD all docks a hydrophobic surface of PKAc regardless of its phosphorylation. PKAc may prevent Bcl-xL from rebinding to BAD by phosphorylating human BAD at Ser118; whereas human BAD is phosphorylated on Ser75 in a BAD-Bcl-xL complex, resulting in the dissociation of BAD.
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