NMR Structure/Function Relationships of Peptides Corresponding to the C1B1 Region of PKCγ

The region (101-112) of C1B domain in PKCγ plays a crucial role in the activation of the enzyme and subsequent gap junction inhibition. Substitution studies on peptides correlating to the C1B region show that a flexible structure and ability to be phosphorylated on serine 109 are critical for this purpose.