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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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A New Family of Small (4kDa) Neurotoxins from the Venoms of Spiders of the Genus Phoneutria
- Source: Protein and Peptide Letters, Volume 15, Issue 7, Jul 2008, p. 700 - 708
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- 01 Jul 2008
Abstract
A family of 4kDa neurotoxic peptides was purified from venoms of Phoneutria spiders. All have six cysteine residues, and low similarity with other neurotoxins. Three toxins caused moderate inhibition of L-type Ca2+ channels. The structure of toxin PRTx27C3 was modeled and compared with toxin ADO1. The importance of four residues is suggested.
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