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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Computational Analysis Suggests Beta-Defensins Are Processed to Mature Peptides By Signal Peptidase
- Source: Protein and Peptide Letters, Volume 15, Issue 5, Jun 2008, p. 536 - 540
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- 01 Jun 2008
Abstract
Antimicrobial peptides (AMPs) are generally produced as precursor peptides containing a signal sequence, a pro-region and the mature peptide. A computational analysis of β-defensin precursors predicts cleavage solely by signal peptidase to release the mature peptide, with no pro-region. This supports the extensive transcriptional control of β- defensin expression compared with other AMP genes.
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