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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Synthesis and Biological Evaluation of N-Phosphoryl Dipeptide Derivatives as Potent Apoptosis Inducers
- Source: Protein and Peptide Letters, Volume 15, Issue 4, May 2008, p. 356 - 359
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- 01 May 2008
Abstract
A series of N-phosphoryl dipeptide derivatives with trimethoxyaniline moiety were synthesized, in which compound 2a DIPP-Val-Phe-Ar exhibited the best inhibitory activity against K562 cells with the IC50 at 9.7 μM. Its antitumor effects are due to the induction of apoptosis which was further confirmed by morphological study and flow cytometry analysis.
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