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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Normal Cytochrome c Oxidase Activity in Prion Protein Gene-Deficient Mice
- Source: Protein and Peptide Letters, Volume 15, Issue 3, Mar 2008, p. 250 - 254
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- 01 Mar 2008
Abstract
Cytochrome c oxidases of prion protein (PrP) gene-deficient (Prnp-/-) and Prnp+/+ mice were examined in vivo and in vitro. Non-invasive near-infrared spectra revealed that oxidation of copper and heme a+a3 in cytochrome c oxidase of Prnp-/- mice was similar to that in Prnp+/+ mice. Biochemical analysis of mitochondrial fractions also supported the results. PrP might not be involved in regulation of cytochrome c oxidase.
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