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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Structure-Activity Relationships of the Dimeric Analogues of Endomorphin-2 with Different Lengths of Spacers
- Source: Protein and Peptide Letters, Volume 15, Issue 3, Mar 2008, p. 275 - 279
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- 01 Mar 2008
Abstract
In the present study, seven novel dimeric analogues of endomorphin-2 with longer spacers were designed and synthesized. Through dimerization, their affinity for δ-opioid receptor was mostly increased, especially the δ-opioid receptor preferred dimeric analogue, DEM12. The results were confirmed by the in vitro bioassay. The structure-activity relationships were also discussed.
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