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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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S-adenosylmethionine Inhibits Ubiquitin-Proteasome System In Vitro and on Rat Vascular Smooth Muscle Cells
- Source: Protein and Peptide Letters, Volume 15, Issue 1, Jan 2008, p. 58 - 62
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- 01 Jan 2008
Abstract
S-adenosylmethionine is a metabolite regulating many biological processes; S-adenosylmethionine effect on ubiquitin-proteasome system (UPS) has not been studied yet. We investigated S-adenosylmethionine effects on UPS activity both in vitro, by inhibitor screening assay, and in rat vascular smooth muscle cells, by Western Blot of proteasomal targets. We found that S-adenosylmethionine inhibited UPS activity.
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