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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Detection of a γ-Carboxy-Glutamate as Novel Post-Translational Modification of Human Transthyretin
- Source: Protein and Peptide Letters, Volume 15, Issue 1, Jan 2008, p. 43 - 46
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- 01 Jan 2008
Abstract
During analysis of the proteome in the cerebrospinal fluid (CSF) of the Caucasian form of moyamoya disease (MMD), a novel post-translational modification of human transthyretin was observed. Two-dimensional electrophoresis and subsequent peptide sequencing with ESI-MS/MS were performed to discover the γ-carboxylation of the Glu-42 (Gla- 42).
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