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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Chimeric T Helper-B Cell Peptides Induce Protective Response Against Japanese Encephalitis Virus in Mice
- Source: Protein and Peptide Letters, Volume 14, Issue 6, Jun 2007, p. 543 - 551
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- 01 Jun 2007
Abstract
Virus neutralizing MAb binding and T helper cell stimulating peptide epitopes from structural and nonstructural proteins of Japanese encephalitis virus were delineated. It was observed that priming by T helper peptides potentiated neutralizing antibody response against JE virus. Immunization with chimeric T helper - B cell peptides could thus protect mice from lethal challenge with JE virus.
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