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2000
Volume 14, Issue 6
  • ISSN: 0929-8665
  • E-ISSN: 1875-5305

Abstract

Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis, suggesting that loss of this factor may be involved in angiogenic eye disease. Here, we show that PEDF inhibits angiotensin II-induced smooth muscle cell proliferation through its anti-oxidative properties. Our present study suggests that PEDF may play a protective role against atherosclerosis.

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/content/journals/ppl/10.2174/092986607780989976
2007-06-01
2025-05-22
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/content/journals/ppl/10.2174/092986607780989976
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  • Article Type:
    Research Article
Keyword(s): Angiotensin II; atherosclerosis; oxidative stress; PEDF
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