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2000
Volume 14, Issue 5
  • ISSN: 0929-8665
  • E-ISSN: 1875-5305

Abstract

Peptide analogs of tendamistat were synthesized and analyzed for α-amylase inhibitory activity. The pKa of the N-terminal tyrosine was modified by incorporation of ring-substituted analogs, which alters hydrogen bonding capacity. Ki values ranging from 70 to 524 μM generally increased with increasing pKa, indicating a necessity for H-bond donor ability.

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/content/journals/ppl/10.2174/092986607780782867
2007-05-01
2025-05-22
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/content/journals/ppl/10.2174/092986607780782867
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  • Article Type:
    Research Article
Keyword(s): a-amylase; hydrogen bonding; inhibitor; pka; structure-activity relationship; tendamistat
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