A Short C-Terminal Region of Alpha-Synuclein Protects a (R/S)-Nonspecific Esterase from Archaeglobus fulgidus

SeungBum Kim; Mira Kang; Yeonwoo Ryu; T. Doohun Kim

doi:10.2174/092986607780363880

ISSN: 0929-8665
E-ISSN: 1875-5305

A Short C-Terminal Region of Alpha-Synuclein Protects a (R/S)-Nonspecific Esterase from Archaeglobus fulgidus
Authors: SeungBum Kim¹, Mira Kang², Yeonwoo Ryu³ and T. Doohun Kim⁴
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¹ Division of Biotechnology and Molecular Engineering, College of Engineering, Ajou University, Suwon,South Korea. ² Division of Biotechnology and Molecular Engineering, College of Engineering, Ajou University, Suwon,South Korea. ³ Division of Biotechnology and Molecular Engineering, College of Engineering, Ajou University, Suwon,South Korea. ⁴ Division of Biotechnology and Molecular Engineering, College of Engineering, Ajou University, Suwon,South Korea.
Source: Protein and Peptide Letters, Volume 14, Issue 4, Apr 2007, p. 347 - 351
DOI: https://doi.org/10.2174/092986607780363880
- Available online: 01 Apr 2007

Abstract

We show that α-synuclein could assist the molecular activity of a ketoprofen-(R/S) nonspecific esterase from Archaeglobus Fulgidus. Specifically, several synthetic peptides from α-synuclein, each having random coil conformation in far-UV spectra, could protect the enzyme activity against stress conditions such as heat and organic solvents.

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2007-04-01

2025-05-25

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Article Type: Research Article

Keyword(s): esterase; molecular engineering; protective activity; α-Synuclein

A Short C-Terminal Region of Alpha-Synuclein Protects a (R/S)-Nonspecific Esterase from Archaeglobus fulgidus

Abstract

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