Neurotoxic Prion Protein (PrP) Fragment 106-126 Requires the N-terminal Half of the Hydrophobic Region of PrP in the PrP-Deficient Neuronal Cell Line

Akikazu Sakudo; Izuru Nakamura; Deug-Chan Lee; Keiichi Saeki; Kazuyoshi Ikuta; Takashi Onodera

doi:10.2174/092986607779117227

ISSN: 0929-8665
E-ISSN: 1875-5305

Neurotoxic Prion Protein (PrP) Fragment 106-126 Requires the N-terminal Half of the Hydrophobic Region of PrP in the PrP-Deficient Neuronal Cell Line
Authors: Akikazu Sakudo¹, Izuru Nakamura², Deug-Chan Lee³, Keiichi Saeki⁴, Kazuyoshi Ikuta⁵ and Takashi Onodera⁶
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¹ Department of Molecular Immunology, School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan. ² Department of Molecular Immunology, School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan. ³ Department of Molecular Immunology, School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan. ⁴ Department of Molecular Immunology, School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan. ⁵ Department of Molecular Immunology, School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan. ⁶ Department of Molecular Immunology, School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
Source: Protein and Peptide Letters, Volume 14, Issue 1, Jan 2007, p. 1 - 6
DOI: https://doi.org/10.2174/092986607779117227
- Available online: 01 Jan 2007

Abstract

The cytotoxicity of aged PrP(106-126) was examined using an immortalized prion protein (PrP) gene-deficient neuronal cell line. The N-terminal half of the hydrophobic region (HR) but not the octapeptide repeat (OR) of PrP was required for aged PrP(106-126) neurotoxicity, suggesting that neurotoxic signals of aged PrP(106-126) are mediated by this region.

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2007-01-01

2025-05-24

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Article Type: Research Article

Keyword(s): apoptosis; Prion disease; prion protein (PrP); PrP(106-126); PrP-deficient cell line

Neurotoxic Prion Protein (PrP) Fragment 106-126 Requires the N-terminal Half of the Hydrophobic Region of PrP in the PrP-Deficient Neuronal Cell Line

Abstract

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