Unexpected Altered Specificity Is Responsible for St. Louis Encephalitis Virus Recombinant Protease Autoproteolysis

Boris A.M. Pastorino; Christophe N. Peyrefitte; Marc Grandadam; Regine Lebrun; Danielle Moinier; Dominique Rolland; Hugues J. Tolou; Mael Bessaud

doi:10.2174/092986607779117146

ISSN: 0929-8665
E-ISSN: 1875-5305

Unexpected Altered Specificity Is Responsible for St. Louis Encephalitis Virus Recombinant Protease Autoproteolysis
Authors: Boris A.M. Pastorino¹, Christophe N. Peyrefitte², Marc Grandadam³, Regine Lebrun⁴, Danielle Moinier⁵, Dominique Rolland⁶, Hugues J. Tolou⁷ and Mael Bessaud⁸
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¹ Unite de virologie tropicale, IMTSSA, BP 46, 13 998 Marseille armees, France. ² Unite de virologie tropicale, IMTSSA, BP 46, 13 998 Marseille armees, France. ³ Unite de virologie tropicale, IMTSSA, BP 46, 13 998 Marseille armees, France. ⁴ Unite de virologie tropicale, IMTSSA, BP 46, 13 998 Marseille armees, France. ⁵ Unite de virologie tropicale, IMTSSA, BP 46, 13 998 Marseille armees, France. ⁶ Unite de virologie tropicale, IMTSSA, BP 46, 13 998 Marseille armees, France. ⁷ Unite de virologie tropicale, IMTSSA, BP 46, 13 998 Marseille armees, France. ⁸ Unite de virologie tropicale, IMTSSA, BP 46, 13 998 Marseille armees, France.
Source: Protein and Peptide Letters, Volume 14, Issue 1, Jan 2007, p. 79 - 82
DOI: https://doi.org/10.2174/092986607779117146
- Available online: 01 Jan 2007

Abstract

We report herein the study of the cleavage fragments generated by autoproteolysis of the St. Louis encephalitis virus recombinant protease. The cleavage sites leading to truncated forms were identified by microsequencing, which revealed an unexpected altered specificity of the recombinant proteinase towards unusual sequences.

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2007-01-01

2025-05-24

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Article Type: Research Article

Keyword(s): Altered specificity; autoproteolysis; flavivirin; NS3; trypsin-like serine protease

Unexpected Altered Specificity Is Responsible for St. Louis Encephalitis Virus Recombinant Protease Autoproteolysis

Abstract

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