The Prediction of Hydrophobicity Gradients within Membrane Interactive Protein α-Helices Using a Novel Graphical Technique

Here, it is shown that amphiphilicity profiling based on the mean hydrophobic moment provides a simple visual guide for the identification of oblique orientated a-helices. The methodology has an efficiency of circa 70% and predicts that approximately 40% of transmembrane a-helices may possess these structures.