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2000
Volume 13, Issue 5
  • ISSN: 0929-8665
  • E-ISSN: 1875-5305

Abstract

The ORL1 receptors stably expressed in HEK 293 cells can utilize PTX-resistant mutants of GαoA/B to inhibit adenylyl cyclase (AC) and stimulate extracellular signal-regulated protein kinases (ERKs). However, development of AC superactivation and loss of ERK1/2 responsiveness induced by chronic activation of the ORL1 receptors remained PTXsensitive.

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/content/journals/ppl/10.2174/092986606776819547
2006-05-01
2025-06-12
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/content/journals/ppl/10.2174/092986606776819547
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  • Article Type:
    Research Article
Keyword(s): Adenylyl cyclase; ERK; G proteins; ORL1 receptor; signal transduction; superactivation
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