Rattlesnake Hemoglobins: Functional Properties and Tetrameric Stability

Fabio R. Lombardi; Maristella C. Anazetti; Giovanni C. Santos; Johnny R. Olivieri; Walter F. de Azevedo Jr.; Gustavo O. Bonilla-Rodriguez

doi:10.2174/092986606776819484

ISSN: 0929-8665
E-ISSN: 1875-5305

Rattlesnake Hemoglobins: Functional Properties and Tetrameric Stability
Authors: Fabio R. Lombardi¹, Maristella C. Anazetti², Giovanni C. Santos³, Johnny R. Olivieri⁴, Walter F. de Azevedo Jr.⁵ and Gustavo O. Bonilla-Rodriguez⁶
View Affiliations Hide Affiliations

¹ Depto. de Quimica e Ciencias Ambientais, IBILCE-UNESP, Rua Cristovao Colombo 2265, S.J. do Rio Preto SP, Brazil CEP 15054-000, Brazil. ² Depto. de Quimica e Ciencias Ambientais, IBILCE-UNESP, Rua Cristovao Colombo 2265, S.J. do Rio Preto SP, Brazil CEP 15054-000, Brazil. ³ Depto. de Quimica e Ciencias Ambientais, IBILCE-UNESP, Rua Cristovao Colombo 2265, S.J. do Rio Preto SP, Brazil CEP 15054-000, Brazil. ⁴ Depto. de Quimica e Ciencias Ambientais, IBILCE-UNESP, Rua Cristovao Colombo 2265, S.J. do Rio Preto SP, Brazil CEP 15054-000, Brazil. ⁵ Depto. de Quimica e Ciencias Ambientais, IBILCE-UNESP, Rua Cristovao Colombo 2265, S.J. do Rio Preto SP, Brazil CEP 15054-000, Brazil. ⁶ Depto. de Quimica e Ciencias Ambientais, IBILCE-UNESP, Rua Cristovao Colombo 2265, S.J. do Rio Preto SP, Brazil CEP 15054-000, Brazil.
Source: Protein and Peptide Letters, Volume 13, Issue 5, May 2006, p. 517 - 523
DOI: https://doi.org/10.2174/092986606776819484
- Available online: 01 May 2006

Abstract

The present work analyzed the tetrameric stability of the hemoglobins from the rattlesnake C. durissus terrificus using analytical gel filtration chromatography, SAXS and osmotic stress. We show that the dissociation mechanism proposed for L. miliaris hemoglobin does not apply for these hemoglobins, which constitute stable tetramers even at low concentrations.

Article metrics loading...

/content/journals/ppl/10.2174/092986606776819484

2006-05-01

2025-05-26

From This Site

/content/journals/ppl/10.2174/092986606776819484

dcterms_title,dcterms_subject,pub_keyword

-contentType:Contributor -contentType:Concept -contentType:Institution

10

5

Full text loading...

/content/journals/ppl/10.2174/092986606776819484

Article Type: Research Article

Keyword(s): Hemoglobin; rattlesnake; tetramer stability

Rattlesnake Hemoglobins: Functional Properties and Tetrameric Stability

Abstract

From This Site

Most Read This Month

Most Cited Most Cited RSS feed

The LL-37 Antimicrobial Peptide as a Treatment for Systematic Infection of Acinetobacter baumannii in a Mouse Model

FN1 Promotes Thyroid Carcinoma Cell Proliferation and Metastasis by Activating the NF-b Pathway

Wogonin Restrains the Malignant Progression of Lung Cancer Through Modulating MMP1 and PI3K/AKT Signaling Pathway

A Temporin Derived Peptide Showing Antibacterial and Antibiofilm Activities against Staphylococcus aureus

Upregulation of Connexins in the Rat Hippocampal and Cortical Neurons Following Blockade of NMDA Receptors During Postnatal Development

Long Non-coding RNA LINC00473 Promotes Breast Cancer Progression via miR-424-5p/CCNE1 Pathway

Protease Inhibitors (PIs): Candidate Molecules for Crop Protection Formulations against Necrotrophs

Preparation of IgE Antibody and Distribution of IgE⁺ Secretory Cells in the Palatine Tonsil of Bactrian Camel

Different VH3-binding Protein A Resins Show Comparable VH3-binding Mediated Byproduct Separation Capabilities Despite Having Varied Dynamic Binding Capacities Towards A VH3 Fab

Immunogenicity and Neutralization Potential of Recombinant Chimeric Protein Comprising the Catalytic Region of Gp63 of Leishmania and LTB against Leishmania donovani