Structure and Function of Bovine Pancreatic Deoxyribonuclease I

Wei-Jung Chen; Ta-Hsiu Liao

doi:10.2174/092986606776819475

ISSN: 0929-8665
E-ISSN: 1875-5305

Structure and Function of Bovine Pancreatic Deoxyribonuclease I
Authors: Wei-Jung Chen¹ and Ta-Hsiu Liao²
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¹ Institute of Biotechnology, College of Bioresources, National Ilan University and Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, 1 Shen-Lung Rd. Sec. 1, Ilan 260, Taiwan. ² Institute of Biotechnology, College of Bioresources, National Ilan University and Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, 1 Shen-Lung Rd. Sec. 1, Ilan 260, Taiwan.
Source: Protein and Peptide Letters, Volume 13, Issue 5, May 2006, p. 447 - 453
DOI: https://doi.org/10.2174/092986606776819475
- Available online: 01 May 2006

Abstract

Bovine pancreatic deoxyribonuclease I (bpDNase), the first DNase discovered, is the best characterized among various types of DNase. A catalytic mechanism has been suggested based on the X-ray structure of the bpDNase-octamer complex. In this review, we will focus on three aspects: 1) the distinctive functions of the two structural calcium atoms; 2) the biological functions of the two disulfides; and 3) the involvement of the N- and C-terminal fragments in the enzyme folding for activity.

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Article Type: Research Article

Keyword(s): calcium; chemical modification; Deoxyribonuclease; disulfide; enzyme mechanism; protein folding; site-directed mutagenesis

Structure and Function of Bovine Pancreatic Deoxyribonuclease I

Abstract

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