Cyclization of α-Synuclein Derived Peptide Increases Its Chaperone-Like Activity

We have analyzed a series of peptides derived from the C-terminus of α-synuclein for chaperone-like activity. Specifically, a cyclic peptide generated by introducing a disulfide bond was observed to increase chaperone-like activity. This is the first example of a disulfide-crosslinked peptide that exhibits activity against protein aggregation and activity loss.