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2000
Volume 13, Issue 4
  • ISSN: 0929-8665
  • E-ISSN: 1875-5305

Abstract

This review focuses on the structure, function and pathological role of leukocyte function-associated antigen-1 (LFA-1) which is a heterodimeric protein consisting of two subunits. LFA-1 plays a most important role in the immune system including adhesion, extravasation, migration, apoptosis, cytotoxicity, cytokine production, and proliferation of lymphocytes. Therefore, T-cell activation can be suppressed by blocking ICAM-1/LFA-1 interaction in autoimmune diseases and organ transplantation. Many different inhibitors (i.e. antibodies, peptides, small molecules) have been demonstrated to block ICAM-1/LFA-1 interaction, and some of them are promising for medical treatment or have reached clinical trials.

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/content/journals/ppl/10.2174/092986606775974429
2006-04-01
2025-05-20
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/content/journals/ppl/10.2174/092986606775974429
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  • Article Type:
    Research Article
Keyword(s): drug designing; function; LFA-1; pathological role; structure
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