Autoantibody Reaction to Myelin Basic Protein by Plasma Parvovirus B19 IgG in MS Patients

Gregory Thomas; Leonard Rael; Rick Shimonkevitz; Isaac Melamed; David Bar-Or

doi:10.2174/092986606775101715

ISSN: 0929-8665
E-ISSN: 1875-5305

Autoantibody Reaction to Myelin Basic Protein by Plasma Parvovirus B19 IgG in MS Patients
Authors: Gregory Thomas¹, Leonard Rael², Rick Shimonkevitz³, Isaac Melamed⁴ and David Bar-Or⁵
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¹ Department of Trauma Research and Trauma Services, Swedish Medical Center, 501 E. Hampden Avenue, Englewood, CO 80113, USA. ² Department of Trauma Research and Trauma Services, Swedish Medical Center, 501 E. Hampden Avenue, Englewood, CO 80113, USA. ³ Department of Trauma Research and Trauma Services, Swedish Medical Center, 501 E. Hampden Avenue, Englewood, CO 80113, USA. ⁴ Department of Trauma Research and Trauma Services, Swedish Medical Center, 501 E. Hampden Avenue, Englewood, CO 80113, USA. ⁵ Department of Trauma Research and Trauma Services, Swedish Medical Center, 501 E. Hampden Avenue, Englewood, CO 80113, USA.
Source: Protein and Peptide Letters, Volume 13, Issue 2, Feb 2006, p. 109 - 111
DOI: https://doi.org/10.2174/092986606775101715
- Available online: 01 Feb 2006

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Abstract

The etiology of multiple sclerosis (MS) remains unclear. To determine if autoantibodies to myelin basic protein (MBP) are produced during parvovirus B19 infection, A competitive ELISA was performed using plasma from MS patients exhibiting high IgG titers for parvovirus. Our results showed the addition of MBP decreased the binding of IgG to B19 antigen in A dose dependent fashion suggesting A possible link between parvovirus B19 and A subset of patients with clinical MS.

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2006-02-01

2025-05-20

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Article Type: Research Article

Keyword(s): Autoantibody; CNS; Demyelination; Multiple sclerosis; Myelin basic protein; Parvovirus B19

Autoantibody Reaction to Myelin Basic Protein by Plasma Parvovirus B19 IgG in MS Patients

Abstract

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