Pattern of Positions Sensitive to Mutations in Human Haemoglobin α-Chain

In this study, we used the distribution rank, which has been developed by us over the past several years, to quantify 134 mutations in the human hemoglobin α-chain in order to gain an insight into the general pattern in mutations. The results suggest that the pattern presented by distribution rank can approximately estimate the positions that are sensitive to mutations in human hemoglobin α-chain.