Full text loading...
- ISSN: 0929-8665
- E-ISSN: 1875-5305
-
Chemical Synthesis of Proteins and Circular Peptides Using Nα-(1-Phenyl- 2-Mercaptoethyl) Auxiliaries
- Source: Protein and Peptide Letters, Volume 12, Issue 8, Nov 2005, p. 729 - 735
-
- 01 Nov 2005
Abstract
An overview of the applications of Nα-(1-phenyl-2-mercaptoethyl) auxiliary is presented. We describe the on resin preparation (C α-carboxy and thioester) of Nα-auxiliary derivatives of glycine and the synthesis and incorporation of preformed Nα-auxiliary derivatives of glycine and alanine with the protection schemes, including the thiazolidine strategy for SPPS. Such approaches allowed the synthesis of the protein cytochrome b562 as well as native circular peptides after successful removal of the auxiliary.
© Bentham Science Publishers