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2000
Volume 12, Issue 7
  • ISSN: 0929-8665
  • E-ISSN: 1875-5305

Abstract

An antitumour lectin named AAL has been purified from the fruiting body of edible mushroom Agrocybe aegerita. In addition to having a distinct bioactivity, AAL shows strong inhibition effects on human and mouse tumour cells. It has been shown that AAL exerts its antitumour effects via apoptosis-induction. AAL and AAL-lactose complex have been crystallized and their diffraction data were collected with resolution of 2.6 Å and 3.0 Å, respectively. Both crystals belong to space group P 6122 with unit cell parameters a = 123.98 Å, b = 123.98 Å, c = 56.86 Å, a= b=90 , g = 120 and a = 123.69 Å, b = 123.69 Å, c = 56.64 Å, α= β=90 , γ = 120 , respectively.

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/content/journals/ppl/10.2174/0929866054696181
2005-10-01
2025-06-07
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/content/journals/ppl/10.2174/0929866054696181
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  • Article Type:
    Review Article
Keyword(s): antitumour; apoptosis; crystallization; dnase activity; lectin; mushroom
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