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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Amphiphilic α-Helical Antimicrobial Peptides and Their Structure / Function Relationships
- Source: Protein and Peptide Letters, Volume 12, Issue 1, Jan 2005, p. 31 - 39
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- 01 Jan 2005
Abstract
To facilitate microbial membrane invasion, amphiphilic α-helical antimicrobial peptides (α-AMPs) show a spatial segregation of hydrophobic and hydrophilic residues about the α-helical long axis. Here we discuss potential mechanisms by which these peptides are able to disrupt membrane structure and the structural characteristics, which are required for function.
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