Dine (Damage-Induced Neuronal Endopeptidase)

Sumiko Kiryu-Seo; Hiroshi Kiyama

doi:10.2174/0929866043406526

ISSN: 0929-8665
E-ISSN: 1875-5305

Dine (Damage-Induced Neuronal Endopeptidase)
Authors: Sumiko Kiryu-Seo¹ and Hiroshi Kiyama²
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¹ Department of Anatomy and Neurobiology, Osaka City University, Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku Osaka 545-8585, Japan. ² Department of Anatomy and Neurobiology, Osaka City University, Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku Osaka 545-8585, Japan.
Source: Protein and Peptide Letters, Volume 11, Issue 5, Oct 2004, p. 451 - 460
DOI: https://doi.org/10.2174/0929866043406526
- Available online: 01 Oct 2004

Abstract

A unique central nervous system (CNS)-specific metalloprotease, DINE / ECEL1 (damage induced neuronal endopeptidase / endothelin converting enzyme-like 1), has recently been added to the M13 / neprilysin (NEP) family. This enzyme was identified by two groups independently using different approaches. In this review, we introduce the characteristics of DINE / ECEL1 and focus on the mechanism underlying the transcriptional regulation of DINE in response to neuronal injury.

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2004-10-01

2025-06-27

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Article Type: Review Article

Keyword(s): dine; ecel1; leukemia inhibitory factor (lif); neprilysin; nerve injury; neuron; neuropeptides; survival

Dine (Damage-Induced Neuronal Endopeptidase)

Abstract

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