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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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A Simplified Model Of The Binding Interaction Between Stromal Cell-Derived Factor-1 Chemokine And Cxc Chemokine Receptor 4
- Source: Protein and Peptide Letters, Volume 10, Issue 2, Apr 2003, p. 133 - 138
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- 01 Apr 2003
Abstract
We have synthesised the CXC chemokine receptor 4 (29-39) peptide, CXCR4{29-39}. This peptide is located in the N-terminal region of the receptor and is likely to be involved in the docking step of the receptor interaction with its natural ligand stromal cell-derived factor-1 chemokine, SDF-1. Preliminary experiments, performed in the presence of micellar detergents to model a membrane-like environment, show that the (1-17) segment of SDF-1 binds to CXCR4{29-39}.
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