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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Novel “Three-in-one” Peptide Device for Genetic Drug Delivery
- Source: Protein and Peptide Letters, Volume 10, Issue 1, Feb 2003, p. 1 - 7
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- 01 Feb 2003
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Abstract
We here describe a new strategy for the delivery of oligonucleotides to cells that is based on the use of a short peptide containing three functional units: a membrane-penetrating segment, a DNA-binding domain and a cell-localization sequence. The designed vector binds strongly to oligonucleotides and has membrane-perturbing abilities in vitro. This type of multi-functional device may be a powerful tool to achieve efficient delivery of genetic drugs in vivo.
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